Spruce Biosciences, Inc. - Common Stock, par value $0.0001 per share (the "Shares") (SPRB)

Q: What does CUSIP 85209E109 represent in this 13F holders report?

CUSIP 85209E109 is the security identifier for SPRB - Spruce Biosciences, Inc. - Common Stock, par value $0.0001 per share (the "Shares") used to aggregate holder disclosures.

Q: How many institutions held SPRB - Spruce Biosciences, Inc. - Common Stock, par value $0.0001 per share (the "Shares") in Q1 2022?

41 institutional investors reported SPRB - Spruce Biosciences, Inc. - Common Stock, par value $0.0001 per share (the "Shares") for Q1 2022. Use the holders table for investor-level position and value details.

CUSIP: 85209E109

Q1 2022 13F Holders as of 31 Mar 2022

Security type / class: Equity / Common Stock, par value $0.0001 per share (the "Shares")
Total 13F shares: 17,089,653
Total 13F value: $34,351,000
Share change: -619,966
SEC-reported price per share: $2.01
Number of holders: 41
Value change: -$1,832,781
Number of buys: 11
Number of sells: 28
Shares outstanding: 1,373,824

Security key

85209E109

Report period

Q1 2022

Institutions

Top holders

SPRB full security history Ownership snapshot Full 13F holder table Newer quarter: Q3 2025 SPRUCE BIOSCIENCES, INC. SEC filings SPRUCE BIOSCIENCES, INC. company facts

Broader feeds

Latest 13F filings Latest 13D/G filings Investors directory

Reporting periods

Holder history for CUSIP 85209E109

Newer quarter: Q3 2025

Recent filing periods:

Q3 2025

Ownership snapshot

Top reported holders of SPRB - Spruce Biosciences, Inc. - Common Stock, par value $0.0001 per share (the "Shares") (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Comparable stake leader

Novo Holdings A/S

Disclosed value leader

Novo Holdings A/S

Comparable rows

15/15

Latest evidence

31 Dec 2021

13F Lead comparable stake: 329% Showing 1-6 of 15 holder rows.

Quick read

Novo Holdings A/S leads the comparable SEC ownership view at 329%.

15 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.

Open SEC evidence Opens Novo Holdings A/S's linked filing trail.

Comparable ownership Top 5

Novo Holdings A/S 329%

Omega Fund Management, LLC 157%

RiverVest Venture Management LLC 156%

CITADEL ADVISORS LLC 126%

Rock Springs Capital Management LP 118%

Ownership % is shown only when SEC disclosures are safely comparable across share classes.

Detailed SEC evidence table Showing 1-6 of 15 holder rows

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
Novo Holdings A/S	13F Company 13F	329%	$20,134,000 4,514,336 shares	—	31 Dec 2021
Omega Fund Management, LLC	13F Company 13F	157%	$9,638,000 2,161,022 shares	—	31 Dec 2021
RiverVest Venture Management LLC	13F Company 13F	156%	$9,581 2,148,281 shares	—	31 Dec 2021
CITADEL ADVISORS LLC	13F Company 13F	126%	$7,703,000 1,727,101 shares	—	31 Dec 2021
Rock Springs Capital Management LP	13F Company 13F	118%	$7,237,000 1,622,689 shares	—	31 Dec 2021
Aisling Capital Management LP	13F Company 13F	88%	$5,377,000 1,205,511 shares	—	31 Dec 2021

How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q1 2022

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions

17,089,653

Rows available

Investor	Option	Weight %	Change %	SEC-reported value	* Price	Shares	Share Change	Activity	Report Period

^* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.

Compare Q1 2022 vs Q1 2022 Across Filers

Q1 2022 holders

Holder diff

Investor	Q1 2022 Shares	Q1 2022 Shares	Share Diff	Share Chg %	Q1 2022 value	Q1 2022 value	Value change	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend