Spero Therapeutics, Inc. - Common Stock, par value $0.001 per share (SPRO)

Q: What does CUSIP 84833T103 represent in this 13F holders report?

CUSIP 84833T103 is the security identifier for SPRO - Spero Therapeutics, Inc. - Common Stock, par value $0.001 per share used to aggregate holder disclosures.

Q: How many institutions held SPRO - Spero Therapeutics, Inc. - Common Stock, par value $0.001 per share in Q4 2022?

57 institutional investors reported SPRO - Spero Therapeutics, Inc. - Common Stock, par value $0.001 per share for Q4 2022. Use the holders table for investor-level position and value details.

CUSIP: 84833T103

Q4 2022 13F Holders as of 31 Dec 2022

Security type / class: Equity / Common Stock, par value $0.001 per share
Total 13F shares: 14,222,474
Total 13F value: $24,601,496
Share change: -5,647,507
Put/Call ratio: 35%
SEC-reported price per share: $1.73
Number of holders: 57
Value change: -$11,539,486
Number of buys: 24
Number of sells: 36
Shares outstanding: 55,705,828

Security key

84833T103

Report period

Q4 2022

Institutions

Top holders

SPRO full security history Ownership snapshot Full 13F holder table Newer quarter: Q3 2026 Spero Therapeutics, Inc. SEC filings Spero Therapeutics, Inc. company facts

Broader feeds

Latest 13F filings Latest 13D/G filings Investors directory

Reporting periods

Holder history for CUSIP 84833T103

Newer quarter: Q3 2026

Recent filing periods:

Q3 2026

Ownership snapshot

Top reported holders of SPRO - Spero Therapeutics, Inc. - Common Stock, par value $0.001 per share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Comparable stake leader

GSK plc

Disclosed value leader

GSK plc

Comparable rows

0/15

Latest evidence

07 Nov 2022

3/4/5 13F Highest disclosed value: $11,672,070 15 rows are not safely comparable across share classes. Showing 1-6 of 15 holder rows.

Quick read

GSK plc has the largest disclosed position value at $11.67M.

0 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.

Open SEC evidence Opens GSK plc's linked filing trail.

Disclosed position value Top 5

GSK plc $11.67M

Aquilo Capital Management, LLC $6.81M

AWM Investment Company, Inc. $4.6M

BVF INC/IL $3.86M

Anson Funds Management LP $2.95M

Value bars compare disclosed positions; verify each figure against the linked filing evidence.

Detailed SEC evidence table Showing 1-6 of 15 holder rows

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
GSK plc	3/4/5 10%+ Owner 3/4/5	— denominator unverified	$11,672,070 9,190,606 shares	—	07 Nov 2022
Aquilo Capital Management, LLC	13F 3/4/5 Company · 10%+ Owner 13F 3/4/5	— denominator unverified	$6,806,000 3,403,210 shares	—	30 Sep 2022
AWM Investment Company, Inc.	13F Company 13F	— denominator unverified	$4,601,000 2,300,400 shares	—	30 Sep 2022
BVF INC/IL	13F Company 13F	— denominator unverified	$3,859,000 1,929,376 shares	—	30 Sep 2022
Anson Funds Management LP	13F Company 13F	— denominator unverified	$2,948,000 1,473,872 shares	—	30 Sep 2022
Atlas Venture Associates IX, LLC	13F Company 13F	— denominator unverified	$2,754,000 1,376,968 shares	—	30 Sep 2022

How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q4 2022

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions

14,222,474

Rows available

Investor	Option	Weight %	Change %	SEC-reported value	* Price	Shares	Share Change	Activity	Report Period

^* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.

Compare Q4 2022 vs Q3 2022 Across Filers

Q3 2022 holders

Q4 2022 holders

Holder diff

-4

Investor	Q3 2022 Shares	Q4 2022 Shares	Share Diff	Share Chg %	Q3 2022 value	Q4 2022 value	Value change	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend