Skye Bioscience, Inc. - Common Stock, par value $0.001 (SKYE) Institutional Ownership

13F Institutional Holders and Ownership History from Q4 2023 to Q4 2025

Type / Class
Equity / Common Stock, par value $0.001
Symbol
SKYE on Nasdaq
Shares outstanding
33,945,050
Price per share
$0.75
All holders as of 30 Sep 2025
Q3 2025
Total 13F shares
19,883,163
Total reported value
$78,141,353
% of total 13F portfolios
0%
Share change
-517,005
Value change
-$2,101,329
Number of holders
56
Price from insider filings
$0.75
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Skye Bioscience, Inc. - Common Stock, par value $0.001 (SKYE) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
5AM Partners VII, LLC 34% -6.7% $15,119,125 -$203,807 11,541,317 -1.3% Andrew J. Schwab 12 Dec 2025
SPHERA FUNDS MANAGEMENT LTD. 4.8% $2,952,706 1,476,353 Sphera Funds Management Ltd. 31 Mar 2025
Schonfeld Strategic Advisors LLC 3.6% -32% $4,441,437 -$1,996,997 1,115,939 -31% Schonfeld Strategic Advisors LLC 30 Jun 2025

As of 30 Sep 2025, 56 institutional investors reported holding 19,883,163 shares of Skye Bioscience, Inc. - Common Stock, par value $0.001 (SKYE). This represents 59% of the company’s total 33,945,050 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Skye Bioscience, Inc. - Common Stock, par value $0.001 (SKYE) together control 58% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
5AM Venture Management, LLC 29% 9,681,763 -2.3% 14% $38,049,329
Versant Venture Management, LLC 5.9% 2,007,704 0% 3.7% $7,890,277
BAKER BROS. ADVISORS LP 4.3% 1,450,638 0% 0.04% $5,701,007
Schonfeld Strategic Advisors LLC 3.5% 1,187,214 +8.1% 0.03% $4,665,748
VANGUARD GROUP INC 2.6% 882,785 +5.3% 0% $3,469,345
Ensign Peak Advisors, Inc 2.3% 767,287 0% 0% $3,015,438
Driehaus Capital Management LLC 1.8% 620,395 0% 0.02% $2,438,152
SPHERA FUNDS MANAGEMENT LTD. 1.4% 478,928 -11% 0.45% $1,882,187
Alyeska Investment Group, L.P. 1.3% 456,163 0% 0.01% $1,792,721
MILLENNIUM MANAGEMENT LLC 1.2% 402,375 -15% 0% $1,581,334
BlackRock, Inc. 0.82% 279,861 -32% 0% $1,099,854
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.79% 269,734 -7% 0% $1,060,055
MARSHALL WACE, LLP 0.74% 251,645 +141% 0% $988,965
PLATINUM INVESTMENT MANAGEMENT LTD 0.69% 233,095 -21% 0.06% $916,063
GEODE CAPITAL MANAGEMENT, LLC 0.61% 208,598 +3.3% 0% $820,083
BOOTHBAY FUND MANAGEMENT, LLC 0.31% 106,270 0.01% $417,641
TWO SIGMA INVESTMENTS, LP 0.27% 92,318 +46% 0% $362,810
STATE STREET CORP 0.22% 75,326 +13% 0% $296,031
GOLDMAN SACHS GROUP INC 0.22% 73,126 -0.96% 0% $287,385
Capital Advisors Wealth Management, LLC 0.13% 44,517 -12% 0.02% $174,952
BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.12% 42,000 0% 0% $165,060
UBS Group AG 0.09% 29,990 -28% 0% $117,861
Zurcher Kantonalbank (Zurich Cantonalbank) 0.09% 29,265 -8.1% 0% $115,011
NORTHERN TRUST CORP 0.09% 29,004 0% 0% $113,986
CITADEL ADVISORS LLC 0.08% 28,852 0% $113,388

Institutional Holders of Skye Bioscience, Inc. - Common Stock, par value $0.001 (SKYE) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 8 $6 +$6 $0.75 1
2025 Q3 19,883,163 $78,141,353 -$2,101,329 $3.93 56
2025 Q2 20,399,360 $85,269,369 -$12,432,557 $4.18 54
2025 Q1 24,700,100 $39,307,441 -$1,237,638 $1.59 72
2024 Q4 25,208,315 $71,310,457 -$3,219,919 $2.83 70
2024 Q3 25,729,728 $100,585,169 +$1,208,054 $3.91 72
2024 Q2 24,496,645 $196,252,371 +$179,861,577 $8.01 62
2024 Q1 2,009,303 $31,404,827 +$31,400,475 $15.64 3
2023 Q4 1,600 $4,352 $2.72 1