Comparable stake leader
5AM Partners VII, LLC
SEC ownership of Skye Bioscience, Inc.
Top holders, 13D/G large-stake signals, insider positions, and transaction flow tied to CIK 0001516551.
Disclosed value leader
5AM Partners VII, LLC
Comparable rows
42/50
Latest evidence
31 Mar 2026
- Public ticker
- SKYE on Nasdaq
- Parsed ownership sources
- 3/4/5, 13D/G, and 13F
- Largest SEC-reported holder
- 5AM Partners VII, LLC
- Latest 13D/G holder
- 5AM Partners VII, LLC
- Latest parsed ownership date
- 31 Mar 2026
- Issuer CIK
- 0001516551
- Issuer location
- San Diego, CA
Ownership snapshot
CIK-linked ownership evidence from parsed SEC filings.
2 signals
Issuer
Names, identifiers, and filing context for this profile.
2 identity fields
Ownership snapshot
Top shareholders of Skye Bioscience, Inc. (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.
Comparable stake leader
5AM Partners VII, LLC
Disclosed value leader
5AM Partners VII, LLC
Comparable rows
42/50
Latest evidence
31 Mar 2026
3/4/5
13D/G
13F
Lead comparable stake: 34%
8 rows are not safely comparable across share classes.
13D/G row: 5AM Partners VII, LLC
Showing 1-8 of 50 holder rows.
Quick read
5AM Partners VII, LLC leads the comparable SEC ownership view at 34%.
42 of 50 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.
Open SEC evidence
Opens 5AM Partners VII, LLC's linked filing trail.
Comparable ownership
Top 5
5AM Partners VII, LLC
34%
SPHERA FUNDS MANAGEMENT LTD.
4.8%
Schonfeld Strategic Advisors LLC
3.6%
Christopher Twitty
0.24%
Tuan Tu Diep
0.01%
Ownership % is shown only when SEC disclosures are safely comparable across share classes.
Detailed SEC evidence table Showing 1-8 of 50 holder rows
| Holder | Evidence | Ownership % | Position | 12M Net Δ | As of |
|---|---|---|---|---|---|
| 5AM Partners VII, LLC |
3/4/5
13D/G
10%+ Owner · Andrew J. Schwab
|
34%
from 13D/G
|
$34,663,397
9,681,763 shares
|
-$800,549 | 21 Aug 2025 |
| SPHERA FUNDS MANAGEMENT LTD. |
13D/G
13F
Company
|
4.8%
|
$2,952,706
1,476,353 shares
|
$0 | 31 Mar 2025 |
| Schonfeld Strategic Advisors LLC |
13D/G
|
3.6%
|
$4,441,437
1,115,939 shares
|
-$1,996,997 | 30 Jun 2025 |
| Christopher Twitty |
3/4/5
Chief Scientific Officer
|
0.24%
|
$147,251
81,242 shares
|
— | 31 Mar 2026 |
| Tuan Tu Diep |
3/4/5
Chief Operating Officer
|
0.01%
|
$2,880
4,000 shares
|
— | 31 Mar 2026 |
| 5AM Venture Management, LLC |
13F
Company
|
29%
|
$5,950,412
9,681,763 shares
|
— | 31 Mar 2026 |
| Versant Venture Management, LLC |
13F
Company
|
5.9%
|
$1,233,935
2,007,704 shares
|
— | 31 Mar 2026 |
| BAKER BROS. ADVISORS LP |
13F
Company
|
4.6%
|
$968,144
1,575,243 shares
|
— | 31 Mar 2026 |
How to read this table
Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
Forms 3/4/5 flow
Insider trading overview
Net insider flow leans to selling over the last 12 months. Net value: -$1,601,097.
Buys
$0
Insiders: 0
Sells
$1,601,097
Insiders: 2
Net
-$1,601,097
Shares: -462,810
Window
Last 12 months
4 rolling buckets
Buy value
Sell value
Shares: 0
Shares: 462,810
| Window (months) | Buy shares | Sell shares | Buy value | Sell value | Net value |
|---|---|---|---|---|---|
| 0-3 | 0 | 0 | $0 | $0 | $0 |
| 3-6 | 0 | 0 | $0 | $0 | $0 |
| 6-9 | 0 | 0 | $0 | $0 | $0 |
| 9-12 | 0 | 462,810 | $0 | $1,601,097 | -$1,601,097 |
Reporting owners
Insider holders from Forms 3/4/5
Showing 1-19 of 19 reporting-owner rows connected to Skye Bioscience, Inc.. Open a relationship link for the CIK-to-CIK filing trail.
Rows
19
Largest Forms 3/4/5 holder
Andrew J. Schwab
Net 12M change
-$1,601,098
Latest report
31 Mar 2026
Recent insider transactions for Skye Bioscience, Inc.
Showing up to 300 recent insider transactions from the last 12 months.
| Insider | Symbol | Class | Transaction | % | SEC-reported value | SEC-reported price | Shares | Shares owned | Date | Ownership |
|---|---|---|---|---|---|---|---|---|---|---|
| Karen L. Smith | SKYE | Stock Option (Right to Buy) | Award | 75,000 | 75,000 | 31 Mar 2026 | Direct | |||
| Christopher Twitty | SKYE | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -461,104 | 0 | 31 Mar 2026 | Direct | ||
| Christopher Twitty | SKYE | Stock Option (Right to Buy) | Award | 461,104 | 200,000 | 31 Mar 2026 | Direct | |||
| Annalisa Jenkins | SKYE | Stock Option (Right to Buy) | Award | 75,000 | 75,000 | 31 Mar 2026 | Direct | |||
| Deborah H. Charych | SKYE | Stock Option (Right to Buy) | Award | 75,000 | 75,000 | 31 Mar 2026 | Direct | |||
| Paul A. Grayson | SKYE | Stock Option (Right to Buy) | Award | 75,000 | 75,000 | 31 Mar 2026 | Direct | |||
| Andrew J. Schwab | SKYE | Stock Option (Right to Buy) | Award | 75,000 | 75,000 | 31 Mar 2026 | Direct | |||
| Tuan Tu Diep | SKYE | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -396,295 | 0 | 31 Mar 2026 | Direct | ||
| Tuan Tu Diep | SKYE | Stock Option (Right to Buy) | Award | 396,295 | 150,000 | 31 Mar 2026 | Direct | |||
| Punit S. Dhillon | SKYE | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -1,103,959 | 0 | 31 Mar 2026 | Direct | ||
| Punit S. Dhillon | SKYE | Stock Option (Right to Buy) | Award | 1,103,959 | 650,000 | 31 Mar 2026 | Direct | |||
| Andrew J. Schwab | SKYE | Stock Option (Right to Buy) | Award | 35,000 | 35,000 | 06 Feb 2026 | Direct | |||
| Paul A. Grayson | SKYE | Stock Option (Right to Buy) | Award | 35,000 | 35,000 | 06 Feb 2026 | Direct | |||
| Karen L. Smith | SKYE | Stock Option (Right to Buy) | Award | 35,000 | 35,000 | 06 Feb 2026 | Direct | |||
| Kaitlyn Arsenault | SKYE | Stock Option (Right to Buy) | Award | 125,000 | 125,000 | 06 Feb 2026 | Direct | |||
| Christopher Twitty | SKYE | Stock Option (Right to Buy) | Award | 150,000 | 150,000 | 06 Feb 2026 | Direct | |||
| Deborah H. Charych | SKYE | Stock Option (Right to Buy) | Award | 35,000 | 35,000 | 06 Feb 2026 | Direct | |||
| Annalisa Jenkins | SKYE | Stock Option (Right to Buy) | Award | 35,000 | 35,000 | 06 Feb 2026 | Direct | |||
| Tuan Tu Diep | SKYE | Stock Option (Right to Buy) | Award | 125,000 | 125,000 | 06 Feb 2026 | Direct | |||
| Puneet S. Arora | SKYE | Stock Option (Right to Buy) | Award | 125,000 | 125,000 | 06 Feb 2026 | Direct | |||
| Punit Dhillon | SKYE | Stock Option (Right to Buy) | Award | 280,000 | 280,000 | 06 Feb 2026 | Direct | |||
| Andrew J. Schwab | SKYE | Common Stock | Sale | -10.1% | $22,127 | $3.42 | -6,470 | 57,493 | 22 Aug 2025 | By 5AM Co-Investors II, L.P. |
| Andrew J. Schwab | SKYE | Common Stock | Sale | -10.1% | $560,808 | $3.42 | -163,979 | 1,457,064 | 22 Aug 2025 | By 5AM Ventures II, L.P. |
| 5AM Partners VII, LLC | SKYE | Common Stock | Sale | -10.1% | $22,127 | $3.42 | -6,470 | 57,493 | 22 Aug 2025 | By 5AM Co-Investors II, L.P. |
| 5AM Partners VII, LLC | SKYE | Common Stock | Sale | -10.1% | $560,808 | $3.42 | -163,979 | 1,457,064 | 22 Aug 2025 | By 5AM Ventures II, L.P. |
| Andrew J. Schwab | SKYE | Common Stock | Sale | -3.49% | $8,261 | $3.57 | -2,314 | 63,963 | 21 Aug 2025 | By 5AM Co-Investors II, L.P. |
| Andrew J. Schwab | SKYE | Common Stock | Sale | -3.49% | $209,352 | $3.57 | -58,642 | 1,621,043 | 21 Aug 2025 | By 5AM Ventures II, L.P. |
| 5AM Partners VII, LLC | SKYE | Common Stock | Sale | -3.49% | $8,261 | $3.57 | -2,314 | 63,963 | 21 Aug 2025 | By 5AM Co-Investors II, L.P. |
| 5AM Partners VII, LLC | SKYE | Common Stock | Sale | -3.49% | $209,352 | $3.57 | -58,642 | 1,621,043 | 21 Aug 2025 | By 5AM Ventures II, L.P. |
* marks a reported price that did not pass the local price check.