SEC ownership of Skye Bioscience, Inc.

Top holders, 13D/G large-stake signals, insider positions, and transaction flow tied to CIK 0001516551.

Comparable stake leader

5AM Partners VII, LLC

Disclosed value leader

5AM Venture Management, LLC

Comparable rows

50/50

Latest evidence

22 Sep 2026

Top shareholders Insider holders Latest transactions
Public ticker
SKYE on Nasdaq
Parsed ownership sources
13D/G, 3/4/5, and 13F
Source: Parsed SEC ownership filingsUse: Compare filing families carefully
Largest SEC-reported holder
5AM Partners VII, LLC
Ranking: Comparable ownership first, then disclosed value
Ownership snapshot CIK-linked ownership evidence from parsed SEC filings. 3 signals
Comparable ownership rows
50 of 50
Meaning: Rows with safely comparable ownership %
Latest 13D/G holder
5AM Partners VII, LLC
Source: Latest parsed Schedule 13D/G stake
Latest parsed ownership date
22 Sep 2026
Freshness: Most recent filing date in this holder set
Issuer Names, identifiers, and filing context for this profile. 2 identity fields
Issuer CIK
0001516551
Issuer location
San Diego, CA

Ownership snapshot

Top shareholders of Skye Bioscience, Inc. (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Comparable stake leader
5AM Partners VII, LLC
Disclosed value leader
5AM Venture Management, LLC
Comparable rows
50/50
Latest evidence
22 Sep 2026
13D/G 3/4/5 13F Lead comparable stake: 26% 13D/G row: 5AM Partners VII, LLC Showing 1-8 of 50 holder rows.

Quick read

5AM Partners VII, LLC leads the comparable SEC ownership view at 26%.

50 of 50 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.

Open SEC evidence Opens 5AM Partners VII, LLC's linked filing trail.
Comparable ownership Top 5
5AM Partners VII, LLC 26%
SPHERA FUNDS MANAGEMENT LTD. 4.8%
Schonfeld Strategic Advisors LLC 3.6%
Punit Dhillon 3.8%
5AM CO-INVESTORS II LP 2.6%

Ownership % is shown only when SEC disclosures are safely comparable across share classes.

Detailed SEC evidence table Showing 1-8 of 50 holder rows
Holder Evidence Ownership % Position 12M Net Δ As of
5AM Partners VII, LLC
13D/G 3/4/5
Andrew J. Schwab · 10%+ Owner
13D/G 3/4/5
26%
$2,460,538
1,218,088 shares
 $0 22 Sep 2026
SPHERA FUNDS MANAGEMENT LTD.
13D/G 13F
Company
13D/G 13F
4.8%
$2,952,706
1,476,353 shares
 $0 31 Mar 2025
Schonfeld Strategic Advisors LLC
13D/G
13D/G
3.6%
$4,441,437
1,115,939 shares
 -$1,996,997 30 Jun 2025
Punit Dhillon
3/4/5
Chief Executive Officer, Director
3/4/5
3.8%
$1,071,874
1,429,166 shares
 — 07 Aug 2026
5AM CO-INVESTORS II LP
3/4/5
10%+ Owner
3/4/5
2.6%
$680,313
981,269 shares
 -$444,602 22 Sep 2026
5AM Partners II, LLC
3/4/5
10%+ Owner
3/4/5
2.6%
$680,313
981,269 shares
 -$444,602 22 Sep 2026
5AM Ventures II LP
3/4/5
10%+ Owner
3/4/5
2.6%
$680,313
981,269 shares
 -$444,602 22 Sep 2026
5AM Ventures VII, L.P.
3/4/5
10%+ Owner
3/4/5
2.6%
$680,313
981,269 shares
 -$444,602 22 Sep 2026
How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

Forms 3/4/5 flow

Insider trading overview

Net insider flow leans to selling over the last 12 months. Net value: -$4,001,417.

Buys
$0
Insiders: 0
Sells
$4,001,417
Insiders: 9
Net
-$4,001,417
Shares: -5,020,299
Window
Last 12 months
4 rolling buckets
Buy value Sell value
Shares: 0 Shares: 5,020,299
Window (months) Buy shares Sell shares Buy value Sell value Net value
0-3 0 5,020,299 $0 $4,001,417 -$4,001,417
3-6 0 0 $0 $0 $0
6-9 0 0 $0 $0 $0
9-12 0 0 $0 $0 $0

Reporting owners

Insider holders from Forms 3/4/5

Showing 1-20 of 26 reporting-owner rows connected to Skye Bioscience, Inc.. Open a relationship link for the CIK-to-CIK filing trail.

Rows
26
Largest Forms 3/4/5 holder
Versant Ventures III, LLC
Net 12M change
-$4,001,418
Latest report
22 Sep 2026
Name Relationship Holdings Value Past Year Net Change Change % Valuation Report Date
Versant Ventures III, LLC 10%+ Owner $9,386,012 Mixed 18 Aug 2023
Emerald Health Sciences Inc. 10%+ Owner $3,167,928 Mixed 10 Nov 2022
Punit Dhillon Chief Executive Officer, Director $1,071,874 Mixed 07 Aug 2026
Kaitlyn Arsenault Chief Financial Officer $835,935 Filing P/S 06 Feb 2026
Kush Parmar 10%+ Owner $680,313 -$444,602 -40% Median 22 Sep 2026
5AM CO-INVESTORS II LP 10%+ Owner $680,313 -$444,602 -40% Median 22 Sep 2026
John D. Diekman 10%+ Owner $680,313 -$444,602 -40% Median 22 Sep 2026
Andrew J. Schwab Director, 10%+ Owner $680,313 -$444,602 -40% Median 22 Sep 2026
5AM Ventures VII, L.P. 10%+ Owner $680,313 -$444,602 -40% Median 22 Sep 2026
5AM Partners II, LLC 10%+ Owner $680,313 -$444,602 -40% Median 22 Sep 2026
5AM Partners VII, LLC 10%+ Owner $680,313 -$444,602 -40% Median 22 Sep 2026
Scott M. Rocklage 10%+ Owner $680,313 -$444,602 -40% Median 22 Sep 2026
5AM Ventures II LP 10%+ Owner $680,313 -$444,602 -40% Median 22 Sep 2026
Christopher Twitty Chief Scientific Officer $147,251 Mixed 31 Mar 2026
Tuan Tu Diep Chief Operating Officer $2,880 Mixed 31 Mar 2026
John P. Sharp Chief Financial Officer Mixed 31 Mar 2026
Karen L. Smith Director Mixed 31 Mar 2026
Puneet S. Arora Chief Medical Officer Mixed 06 Feb 2026
James L. Heppell Director Mixed 14 Sep 2021
Annalisa Jenkins Director Mixed 31 Mar 2026

Recent insider transactions for Skye Bioscience, Inc.

Showing up to 300 recent insider transactions from the last 12 months.

Insider Symbol Class Transaction % SEC-reported value SEC-reported price Shares Shares owned Date Ownership
Andrew J. Schwab SKYE Common Stock Sale -100% $7,290 $1.61 -4,528 0 23 Sep 2026 By 5AM Co-Investors II, L.P.
Andrew J. Schwab SKYE Common Stock Sale -100% $184,910 $1.61 -114,851 0 23 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -100% $7,290 $1.61 -4,528 0 23 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -100% $7,290 $1.61 -4,528 0 23 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -100% $7,290 $1.61 -4,528 0 23 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -100% $7,290 $1.61 -4,528 0 23 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -100% $7,290 $1.61 -4,528 0 23 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -100% $7,290 $1.61 -4,528 0 23 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -100% $7,290 $1.61 -4,528 0 23 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -100% $7,290 $1.61 -4,528 0 23 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -100% $184,910 $1.61 -114,851 0 23 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -100% $184,910 $1.61 -114,851 0 23 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -100% $184,910 $1.61 -114,851 0 23 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -100% $184,910 $1.61 -114,851 0 23 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -100% $184,910 $1.61 -114,851 0 23 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -100% $184,910 $1.61 -114,851 0 23 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -100% $184,910 $1.61 -114,851 0 23 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -100% $184,910 $1.61 -114,851 0 23 Sep 2026 By 5AM Ventures II, L.P.
Andrew J. Schwab SKYE Common Stock Sale -19.4% $1,795 $1.65 -1,088 4,528 22 Sep 2026 By 5AM Co-Investors II, L.P.
Andrew J. Schwab SKYE Common Stock Sale -19.4% $45,560 $1.65 -27,612 114,851 22 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -19.4% $1,795 $1.65 -1,088 4,528 22 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -19.4% $1,795 $1.65 -1,088 4,528 22 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -19.4% $1,795 $1.65 -1,088 4,528 22 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -19.4% $1,795 $1.65 -1,088 4,528 22 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -19.4% $1,795 $1.65 -1,088 4,528 22 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -19.4% $1,795 $1.65 -1,088 4,528 22 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -19.4% $1,795 $1.65 -1,088 4,528 22 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -19.4% $1,795 $1.65 -1,088 4,528 22 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -19.4% $45,560 $1.65 -27,612 114,851 22 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -19.4% $45,560 $1.65 -27,612 114,851 22 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -19.4% $45,560 $1.65 -27,612 114,851 22 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -19.4% $45,560 $1.65 -27,612 114,851 22 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -19.4% $45,560 $1.65 -27,612 114,851 22 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -19.4% $45,560 $1.65 -27,612 114,851 22 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -19.4% $45,560 $1.65 -27,612 114,851 22 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -19.4% $45,560 $1.65 -27,612 114,851 22 Sep 2026 By 5AM Ventures II, L.P.
Andrew J. Schwab SKYE Common Stock Sale -18.6% $2,454 $1.91 -1,285 5,616 16 Sep 2026 By 5AM Co-Investors II, L.P.
Andrew J. Schwab SKYE Common Stock Sale -18.6% $62,279 $1.91 -32,607 142,463 16 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -18.6% $2,454 $1.91 -1,285 5,616 16 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -18.6% $2,454 $1.91 -1,285 5,616 16 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -18.6% $2,454 $1.91 -1,285 5,616 16 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -18.6% $2,454 $1.91 -1,285 5,616 16 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -18.6% $2,454 $1.91 -1,285 5,616 16 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -18.6% $2,454 $1.91 -1,285 5,616 16 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -18.6% $2,454 $1.91 -1,285 5,616 16 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -18.6% $2,454 $1.91 -1,285 5,616 16 Sep 2026 By 5AM Co-Investors II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -18.6% $62,279 $1.91 -32,607 142,463 16 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -18.6% $62,279 $1.91 -32,607 142,463 16 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -18.6% $62,279 $1.91 -32,607 142,463 16 Sep 2026 By 5AM Ventures II, L.P.
5AM Partners VII, LLC SKYE Common Stock Sale -18.6% $62,279 $1.91 -32,607 142,463 16 Sep 2026 By 5AM Ventures II, L.P.
* marks a reported price that did not pass the local price check.
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