| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Teoxane SA | 6.2% | 0% | $32,335,404 | 6,550,800 | 0% | Teoxane SA | 30 Jan 2025 | |
| FRANKLIN RESOURCES INC | 4.6% | $23,617,550 | 4,784,658 | Franklin Resources, Inc. | 30 Sep 2024 | |||
| Palo Alto Investors LP | 1.54% | $7,955,942 | 1,611,787 | Patrick Lee, MD | 30 Sep 2024 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q2 | 0 | $0 | -$425,556 | 0 | |
| 2025 Q1 | 86,100 | $425,000 | -$246,196,147 | $4.94 | 1 |
| 2024 Q4 | 81,619,644 | $248,123,678 | -$34,475,559 | $3.04 | 169 |
| 2024 Q3 | 82,760,696 | $429,420,057 | +$74,534,872 | $5.19 | 197 |
| 2024 Q2 | 81,357,406 | $209,091,543 | -$16,845,100 | $2.57 | 167 |
| 2024 Q1 | 83,208,743 | $409,387,692 | +$36,028,524 | $4.92 | 182 |
| 2023 Q4 | 72,393,492 | $636,347,111 | -$60,448,695 | $8.79 | 188 |
| 2023 Q3 | 77,847,333 | $892,932,350 | -$137,486,235 | $11.47 | 184 |
| 2023 Q2 | 81,758,941 | $2,069,347,401 | +$120,257,967 | $25.31 | 211 |
| 2023 Q1 | 76,516,583 | $2,464,233,089 | +$117,647,825 | $32.21 | 215 |
| 2022 Q4 | 73,838,140 | $1,363,055,604 | +$97,419,982 | $18.46 | 189 |
| 2022 Q3 | 67,635,567 | $1,824,203,436 | +$329,402,349 | $27 | 178 |
| 2022 Q2 | 56,025,691 | $774,315,063 | +$10,576,060 | $13.82 | 156 |
| 2022 Q1 | 54,547,989 | $1,063,491,136 | +$29,861,073 | $19.5 | 149 |
| 2021 Q4 | 52,976,629 | $864,638,987 | -$84,608,748 | $16.32 | 143 |
| 2021 Q3 | 54,870,424 | $1,528,696,909 | +$20,536,734 | $27.86 | 155 |
| 2021 Q2 | 54,097,996 | $1,601,222,557 | -$17,874,204 | $29.64 | 159 |
| 2021 Q1 | 54,835,912 | $1,532,629,456 | +$56,326,804 | $27.95 | 148 |
| 2020 Q4 | 52,750,406 | $1,494,882,254 | +$97,410,291 | $28.34 | 150 |
| 2020 Q3 | 49,472,050 | $1,246,067,821 | -$26,647,818 | $25.14 | 151 |
| 2020 Q2 | 50,606,433 | $1,234,538,861 | +$33,125,299 | $24.42 | 138 |
| 2020 Q1 | 49,442,358 | $731,960,359 | -$26,411,053 | $14.8 | 126 |
| 2019 Q4 | 51,033,735 | $828,265,787 | +$132,605,351 | $16.23 | 130 |
| 2019 Q3 | 42,640,327 | $554,389,602 | -$12,035,697 | $13 | 106 |
| 2019 Q2 | 43,555,026 | $564,029,588 | +$26,762,019 | $12.97 | 110 |
| 2019 Q1 | 41,642,925 | $656,297,834 | +$99,780,800 | $15.76 | 108 |
| 2018 Q4 | 31,877,280 | $641,628,318 | +$12,346,028 | $20.13 | 97 |
| 2018 Q3 | 34,359,383 | $853,830,934 | -$15,526,982 | $24.85 | 108 |
| 2018 Q2 | 34,870,390 | $957,229,930 | +$13,863,223 | $27.45 | 109 |
| 2018 Q1 | 34,209,499 | $1,053,625,660 | -$35,231,819 | $30.8 | 118 |
| 2017 Q4 | 34,965,934 | $1,250,026,502 | +$169,498,952 | $35.75 | 115 |
| 2017 Q3 | 27,433,692 | $754,721,335 | -$1,638,080 | $27.55 | 84 |
| 2017 Q2 | 27,519,844 | $726,508,386 | +$33,694,307 | $26.4 | 84 |
| 2017 Q1 | 26,264,507 | $546,296,202 | +$45,342,975 | $20.8 | 76 |
| 2016 Q4 | 26,097,588 | $540,211,722 | +$12,064,735 | $20.7 | 80 |
| 2016 Q3 | 28,646,674 | $464,359,406 | -$1,083,385 | $16.21 | 74 |
| 2016 Q2 | 28,779,485 | $391,398,386 | +$16,844,693 | $13.6 | 79 |
| 2016 Q1 | 27,202,736 | $474,936,380 | -$25,989,904 | $17.46 | 83 |
| 2015 Q4 | 27,209,685 | $929,575,673 | +$189,567,566 | $34.16 | 101 |
| 2015 Q3 | 21,644,614 | $644,108,702 | +$34,896,748 | $29.76 | 76 |
| 2015 Q2 | 20,482,234 | $655,028,876 | +$16,033,415 | $31.98 | 88 |
| 2015 Q1 | 20,573,529 | $426,461,171 | +$18,511,994 | $20.73 | 70 |
| 2014 Q4 | 19,758,262 | $334,697,612 | +$8,318,779 | $16.94 | 68 |
| 2014 Q3 | 15,656,921 | $302,653,761 | -$45,140,381 | $19.33 | 80 |
| 2014 Q2 | 16,360,522 | $556,147,916 | +$154,810,773 | $34 | 98 |
| 2014 Q1 | 11,832,924 | $372,736,175 | +$372,736,179 | $31.5 | 65 |