OPKO HEALTH, INC. - Common Stock, par value $0.01 per share (OPK) Institutional Ownership

13F Institutional Holders and Ownership History from Q1 2014 to Q4 2025

Type / Class
Equity / Common Stock, par value $0.01 per share
Symbol
OPK on Nasdaq
Shares outstanding
770,989,043
Price per share
$1.29
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
199,102,919
Total reported value
$250,882,912
% of total 13F portfolios
0%
Share change
+3,319,465
Value change
+$3,540,642
Number of holders
212
Price from insider filings
$1.29
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of OPKO HEALTH, INC. - Common Stock, par value $0.01 per share (OPK) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
FROST PHILLIP MD ET AL 33% +3.4% $351,509,324 +$674,150 252,884,406 +0.19% FROST PHILLIP MD ET AL 30 Sep 2025
Rubric Capital Management LP 6% $63,137,011 47,791,243 Rubric Capital Management LP 30 Jun 2025
HSIAO JANE PH D 4.5% $50,304,970 35,677,284 HSIAO JANE PH D 02 Apr 2025

As of 31 Dec 2025, 212 institutional investors reported holding 199,102,919 shares of OPKO HEALTH, INC. - Common Stock, par value $0.01 per share (OPK). This represents 26% of the company’s total 770,989,043 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of OPKO HEALTH, INC. - Common Stock, par value $0.01 per share (OPK) together control 23% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
Rubric Capital Management LP 6.2% 47,791,243 0% 0.72% $60,216,966
BlackRock, Inc. 4.5% 34,852,030 +5.1% 0% $43,913,559
VANGUARD GROUP INC 4.2% 32,457,788 -14% 0% $40,896,813
GEODE CAPITAL MANAGEMENT, LLC 1.4% 11,061,318 +0.62% 0% $13,939,903
STATE STREET CORP 1.2% 8,951,762 -0.51% 0% $11,279,220
GOLDMAN SACHS GROUP INC 0.78% 5,986,913 +151% 0% $7,543,511
UBS Group AG 0.69% 5,352,784 +12% 0% $6,744,509
Whitefort Capital Management, LP 0.55% 4,253,340 -13% 1.6% $5,359,208
CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.48% 3,692,650 -2% 0% $4,652,739
NORTHERN TRUST CORP 0.45% 3,438,312 -6% 0% $4,332,273
CITADEL ADVISORS LLC 0.37% 2,857,433 +921% 0% $3,600,366
AWM Investment Company, Inc. 0.27% 2,100,000 -4.5% 0.26% $2,646,000
AQR CAPITAL MANAGEMENT LLC 0.26% 2,026,957 -29% 0% $2,553,965
JANE STREET GROUP, LLC 0.23% 1,775,336 +575% 0% $2,236,923
DIMENSIONAL FUND ADVISORS LP 0.21% 1,611,318 -3.4% 0% $2,031,403
WASHINGTON GROWTH STRATEGIES LLC 0.18% 1,356,124 0% 1.1% $1,708,717
PFG Investments, LLC 0.17% 1,320,391 -1.3% 0.08% $1,663,693
Bank of New York Mellon Corp 0.17% 1,310,094 +2.6% 0% $1,650,718
Y.D. More Investments Ltd 0.17% 1,306,452 -13% 0.08% $1,670,948
VOYA INVESTMENT MANAGEMENT LLC 0.14% 1,102,174 -9.5% 0% $1,388,739
MORGAN STANLEY 0.12% 917,352 +9.5% 0% $1,155,864
Clearstead Advisors, LLC 0.11% 882,367 0.01% $1,111,783
Tejara Capital Ltd 0.11% 877,941 0% 0.46% $1,106,206
Swiss National Bank 0.11% 845,755 0% 0% $1,065,651
Nuveen, LLC 0.11% 841,836 0% 0% $1,060,713

Institutional Holders of OPKO HEALTH, INC. - Common Stock, par value $0.01 per share (OPK) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 199,102,919 $250,882,912 +$3,540,642 $1.26 212
2025 Q3 195,971,273 $303,592,966 -$11,767,506 $1.55 230
2025 Q2 205,024,725 $270,648,264 -$60,618,128 $1.32 215
2025 Q1 241,258,198 $400,533,423 +$72,053,389 $1.66 247
2024 Q4 197,412,433 $290,239,287 +$15,903,156 $1.47 230
2024 Q3 186,501,814 $277,905,256 +$7,881,691 $1.49 227
2024 Q2 182,107,019 $227,651,201 +$32,281,850 $1.25 227
2024 Q1 158,173,650 $189,816,225 -$15,412,795 $1.20 218
2023 Q4 169,846,994 $256,508,174 +$2,949,820 $1.51 211
2023 Q3 167,041,124 $267,211,525 -$11,685,601 $1.60 219
2023 Q2 173,057,185 $374,930,496 -$7,391,066 $2.17 224
2023 Q1 177,714,344 $259,294,407 -$3,078,751 $1.46 218
2022 Q4 181,496,897 $226,809,289 -$10,191,947 $1.25 214
2022 Q3 186,517,226 $352,478,417 -$8,899,720 $1.89 200
2022 Q2 189,691,960 $479,863,957 -$13,941,817 $2.53 210
2022 Q1 194,629,054 $670,129,008 +$10,945,254 $3.44 215
2021 Q4 190,116,095 $914,661,536 +$32,672,752 $4.81 222
2021 Q3 183,228,658 $668,852,368 -$29,244,813 $3.65 196
2021 Q2 190,948,492 $773,257,740 +$54,948 $4.05 224
2021 Q1 190,493,255 $817,110,481 +$5,248,916 $4.29 230
2020 Q4 187,898,643 $742,332,468 -$29,923,745 $3.95 229
2020 Q3 195,530,381 $721,219,726 -$13,315,180 $3.69 207
2020 Q2 199,256,349 $679,095,576 +$131,091,146 $3.41 198
2020 Q1 161,765,902 $216,744,574 -$19,687,519 $1.34 167
2019 Q4 176,275,051 $259,136,088 +$41,988,405 $1.47 185
2019 Q3 147,149,372 $307,565,950 -$17,098,653 $2.09 173
2019 Q2 154,503,483 $376,518,250 -$4,451,090 $2.44 185
2019 Q1 159,227,289 $414,802,691 +$39,359,438 $2.61 185
2018 Q4 142,093,268 $427,280,395 -$32,150,016 $3.01 187
2018 Q3 152,164,350 $526,449,630 +$32,002,562 $3.46 197
2018 Q2 140,990,937 $662,674,682 +$30,418,093 $4.70 202
2018 Q1 134,703,173 $426,973,988 +$21,808,219 $3.17 210
2017 Q4 130,845,894 $641,134,531 -$11,914,079 $4.90 217
2017 Q3 131,515,339 $902,006,062 +$9,805,717 $6.86 228
2017 Q2 127,413,444 $838,468,204 -$14,499,676 $6.58 221
2017 Q1 131,302,704 $1,050,471,050 +$158,998,246 $8.00 232
2016 Q4 132,543,971 $1,235,029,545 +$47,421,334 $9.30 241
2016 Q3 127,239,733 $1,345,914,777 +$129,356,378 $10.59 260
2016 Q2 115,306,017 $1,077,026,990 +$41,618,153 $9.34 234
2016 Q1 109,453,682 $1,136,781,775 -$48,177,301 $10.39 248
2015 Q4 115,548,837 $1,161,220,963 -$134,688,417 $10.05 266
2015 Q3 123,052,830 $1,034,135,480 +$270,131,808 $8.41 256
2015 Q2 85,374,333 $1,372,644,135 +$79,586,364 $16.08 215
2015 Q1 80,721,201 $1,142,242,411 +$43,779,625 $14.17 189
2014 Q4 78,028,785 $779,583,900 +$30,051,903 $9.99 175
2014 Q3 74,739,528 $635,901,500 -$64,365,946 $8.51 180
2014 Q2 81,806,864 $723,162,643 +$87,038,633 $8.84 171
2014 Q1 72,774,020 $678,260,259 +$9,369,927 $9.32 165