Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI)

Q: What does CUSIP 48576U106 represent in this 13F holders report?

CUSIP 48576U106 is the security identifier for KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share used to aggregate holder disclosures.

Q: How many institutions held KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share in Q4 2022?

152 institutional investors reported KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share for Q4 2022. Use the holders table for investor-level position and value details.

CUSIP: 48576U106

Q4 2022 13F Holders as of 31 Dec 2022

Security type / class: Equity / Common Stock, par value $0.0001 per share
Shares outstanding: 22,658,403
Total 13F shares: 98,414,676
Share change: +31,404,143
Total reported value: $334,456,268
Put/Call ratio: 140%
Reported price per share: $3.40
Number of holders: 152
Value change: +$99,576,581
Number of buys: 89
Number of sells: 60

Security key

48576U106

Report period

Q4 2022

Institutions

152

Top holders

KPTI full security history Ownership snapshot Full 13F holder table Newer quarter: Q1 2023 Previous quarter: Q3 2022 Karyopharm Therapeutics Inc. SEC filings Karyopharm Therapeutics Inc. company facts

Broader feeds

Latest 13F filings Latest 13D/G filings Investors directory

Reporting periods

Holder history for CUSIP 48576U106

Newer quarter: Q1 2023 Previous quarter: Q3 2022

Recent filing periods:

Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024 Q2 2024

Ownership snapshot

Top shareholders of KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Lead holder

STATE STREET CORP

13D/G signal

—

Evidence rows

Latest as of

30 Sep 2022

13F Lead comparable stake: 40% Showing first 8 of 50 holder rows. Open remaining rows

Rank 1 holder

STATE STREET CORP

13F

Ownership: 40%
Position: $49.2M

13F

Rank 2 holder

BlackRock Finance, Inc.

13F

Ownership: 35%
Position: $43.2M

13F

Rank 3 holder

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
STATE STREET CORP	13F Company 13F	40%	$49,196,000 9,010,339 shares	—	30 Sep 2022
BlackRock Finance, Inc.	13F Company 13F	35%	$43,203,000 7,912,954 shares	—	30 Sep 2022
Palo Alto Investors LP	13F Company 13F	25%	$30,694,000 5,621,533 shares	—	30 Sep 2022
VANGUARD GROUP INC	13F Company 13F	21%	$26,282,000 4,813,399 shares	—	30 Sep 2022
Rubric Capital Management LP	13F Company 13F	18%	$21,786,000 3,990,126 shares	—	30 Sep 2022
Nuveen Asset Management, LLC	13F Company 13F	8.7%	$10,762,000 1,971,048 shares	—	30 Sep 2022
Commodore Capital LP	13F Company 13F	8.5%	$10,568,000 1,935,609 shares	—	30 Sep 2022
CITADEL ADVISORS LLC	13F Company 13F	8%	$9,881,000 1,809,646 shares	—	30 Sep 2022

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
JACOBS LEVY EQUITY MANAGEMENT, INC	13F Company 13F	7%	$8,641,000 1,582,524 shares	—	30 Sep 2022
Ally Bridge Group (NY) LLC	13F Company 13F	6.7%	$8,346,000 1,528,580 shares	—	30 Sep 2022
Woodline Partners LP	13F Company 13F	6.7%	$8,262,000 1,513,259 shares	—	30 Sep 2022
C WorldWide Group Holding A/S	13F Company 13F	6.6%	$8,190,000 1,500,000 shares	—	30 Sep 2022
GOLDMAN SACHS GROUP INC	13F Company 13F	6%	$7,399,000 1,355,176 shares	—	30 Sep 2022
S.c.a. Candriam	13F Individual 13F	5.9%	$7,290,000 1,335,026 shares	—	30 Sep 2022
GEODE CAPITAL MANAGEMENT, LLC	13F Company 13F	5.9%	$7,264,000 1,330,435 shares	—	30 Sep 2022
MORGAN STANLEY	13F Company 13F	4.8%	$5,896,000 1,079,851 shares	—	30 Sep 2022
RICE HALL JAMES & ASSOCIATES, LLC	13F Company 13F	4%	$4,964,000 909,083 shares	—	30 Sep 2022
ACADIAN ASSET MANAGEMENT LLC	13F Company 13F	3.8%	$4,643,000 850,576 shares	—	30 Sep 2022
TWO SIGMA ADVISERS, LP	13F Company 13F	3.7%	$4,539,000 831,300 shares	—	30 Sep 2022
BNP PARIBAS FINANCIAL MARKETS	13F Company 13F	3.4%	$4,163,359 762,520 shares	—	30 Sep 2022
NORTHERN TRUST CORP	13F Company 13F	3.3%	$4,116,000 753,779 shares	—	30 Sep 2022
Altium Capital Management LLC	13F Company 13F	3.3%	$4,095,000 750,000 shares	—	30 Sep 2022
BANK OF AMERICA CORP /DE/	13F Company 13F	3.2%	$3,996,000 731,861 shares	—	30 Sep 2022
ExodusPoint Capital Management, LP	13F Company 13F	3.1%	$3,862,000 707,280 shares	—	30 Sep 2022
Walleye Capital LLC	13F Company 13F	3%	$3,678,000 673,672 shares	—	30 Sep 2022
Rafferty Asset Management, LLC	13F Company 13F	2.9%	$3,647,000 668,004 shares	—	30 Sep 2022
FRONTIER CAPITAL MANAGEMENT CO LLC	13F Company 13F	2.8%	$3,435,000 629,154 shares	—	30 Sep 2022
CITIGROUP INC	13F Company 13F	2.7%	$3,316,000 607,396 shares	—	30 Sep 2022
BALYASNY ASSET MANAGEMENT L.P.	13F Company 13F	2.6%	$3,252,000 595,558 shares	—	30 Sep 2022
DEUTSCHE BANK AG\	13F Company 13F	2.6%	$3,242,000 593,817 shares	—	30 Sep 2022
Lombard Odier Asset Management (Switzerland) SA	13F Company 13F	2.1%	$2,616,000 479,124 shares	—	30 Sep 2022
BARCLAYS PLC	13F Company 13F	2%	$2,487,000 455,464 shares	—	30 Sep 2022
SUSQUEHANNA INTERNATIONAL GROUP, LLP	13F Company 13F	1.7%	$2,139,000 391,917 shares	—	30 Sep 2022
MACQUARIE GROUP LTD	13F Company 13F	1.7%	$2,086,000 381,465 shares	—	30 Sep 2022
RENAISSANCE TECHNOLOGIES LLC	13F Company 13F	1.4%	$1,683,000 308,300 shares	—	30 Sep 2022
Bank of New York Mellon Corp	13F Company 13F	1.3%	$1,632,000 298,991 shares	—	30 Sep 2022
Hennion & Walsh Asset Management, Inc.	13F Company 13F	1.2%	$1,509,000 276,422 shares	—	30 Sep 2022
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC)	13F Company 13F	1.2%	$1,481,000 271,219 shares	—	30 Sep 2022
Birchview Capital, LP	13F Company 13F	1.2%	$1,471,000 269,332 shares	—	30 Sep 2022
MILLENNIUM MANAGEMENT LLC	13F Company 13F	1.2%	$1,434,000 262,686 shares	—	30 Sep 2022
WELLINGTON MANAGEMENT GROUP LLP	13F Company 13F	1.1%	$1,338,000 245,134 shares	—	30 Sep 2022
TWO SIGMA INVESTMENTS, LP	13F Company 13F	1%	$1,247,000 228,335 shares	—	30 Sep 2022
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	13F Company 13F	0.88%	$1,095,000 200,501 shares	—	30 Sep 2022
JPMORGAN CHASE & CO	13F Company 13F	0.79%	$978,000 179,227 shares	—	30 Sep 2022
VOYA INVESTMENT MANAGEMENT LLC	13F Company 13F	0.76%	$937,050 171,621 shares	—	30 Sep 2022
AMERIPRISE FINANCIAL INC	13F Company 13F	0.75%	$929,000 170,029 shares	—	30 Sep 2022
Swiss National Bank	13F Company 13F	0.75%	$925,000 169,450 shares	—	30 Sep 2022
MARSHALL WACE, LLP	13F Company 13F	0.7%	$868,000 159,137 shares	—	30 Sep 2022
Connor, Clark & Lunn Investment Management Ltd.	13F Company 13F	0.69%	$849,000 155,433 shares	—	30 Sep 2022
D. E. Shaw & Co., Inc.	13F Company 13F	0.63%	$785,000 143,806 shares	—	30 Sep 2022

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q4 2022

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions

152

98,414,676

Rows loaded

152

Investor	Option	Weight %	Change %	Reported value	* Price	Shares	Share Change	Activity	Report Period

^* Reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that failed the local validity check.

Compare Q4 2022 vs Q3 2022 Across Filers

Q3 2022 holders

142

Q4 2022 holders

152

Holder diff

Investor	Q3 2022 Shares	Q4 2022 Shares	Share Diff	Share Chg %	Q3 2022 value	Q4 2022 value	Value change	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend

Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI)

Q4 2022 13F Holders as of 31 Dec 2022

Holder history for CUSIP 48576U106

Top shareholders of KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (13F + 13D/G + 3/4/5)

STATE STREET CORP

BlackRock Finance, Inc.

Palo Alto Investors LP

Institutional holders as of Q4 2022

Compare Q4 2022 vs Q3 2022 Across Filers