Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI)

Q: What does CUSIP 48576U106 represent in this 13F holders report?

CUSIP 48576U106 is the security identifier for KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share used to aggregate holder disclosures.

Q: How many institutions held KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share in Q1 2021?

163 institutional investors reported KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share for Q1 2021. Use the holders table for investor-level position and value details.

CUSIP: 48576U106

Q1 2021 13F Holders as of 31 Mar 2021

Type / Class: Equity / Common Stock, par value $0.0001 per share
Shares outstanding: 22,242,217
Total 13F shares: 59,160,795
Share change: -3,844,560
Total reported value: $622,242,344
Put/Call ratio: 247%
Price per share: $10.52
Number of holders: 163
Value change: -$49,072,460
Number of buys: 81
Number of sells: 79

Quarterly Holders Quick Answers

What is CUSIP 48576U106?
CUSIP 48576U106 identifies KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share in SEC institutional holdings data.

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Explore More Reporting Periods

Jump to adjacent filing periods for faster comparison and easier crawl discovery.

Newer quarter: Q2 2021
Previous quarter: Q4 2020

Recent filing periods for CUSIP 48576U106:

Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024 Q2 2024 Q1 2024

Top shareholders of KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.

Methodology: rows are grouped by holder and ranked by the holder's primary source value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

Holder	Source	Role / Reporting	Ownership %	Shares	Holdings Value	12M Net Δ	As of	Details
BlackRock Finance, Inc.	13F	Company	34%	7,475,099	$115,713,000	—	31 Dec 2020	13F
STATE STREET CORP	13F	Company	24%	5,339,859	$82,661,000	—	31 Dec 2020	13F
Palo Alto Investors LP	13F	Company	24%	5,267,652	$81,543,000	—	31 Dec 2020	13F
VANGUARD GROUP INC	13F	Company	16%	3,480,399	$53,877,000	—	31 Dec 2020	13F
FRONTIER CAPITAL MANAGEMENT CO LLC	13F	Company	14%	3,127,571	$48,415,000	—	31 Dec 2020	13F
ALKEON CAPITAL MANAGEMENT LLC	13F	Company	12%	2,666,416	$41,276,000	—	31 Dec 2020	13F
MILLENNIUM MANAGEMENT LLC	13F	Company	11%	2,494,901	$38,621,000	—	31 Dec 2020	13F
ADAGE CAPITAL PARTNERS GP, L.L.C.	13F	Company	11%	2,465,000	$38,158,000	—	31 Dec 2020	13F
Delphi Management Partners VIII, L.L.C.	13F	Company	10%	2,263,006	$35,031,000	—	31 Dec 2020	13F
WELLINGTON MANAGEMENT GROUP LLP	13F	Company	9.8%	2,179,215	$33,734,000	—	31 Dec 2020	13F
EMERALD ADVISERS, LLC	13F	Company	8.2%	1,822,781	$28,217,000	—	31 Dec 2020	13F
EMERALD MUTUAL FUND ADVISERS TRUST	13F	Company	7.5%	1,661,236	$25,716,000	—	31 Dec 2020	13F
RICE HALL JAMES & ASSOCIATES, LLC	13F	Company	7%	1,552,504	$24,033,000	—	31 Dec 2020	13F
PRICE T ROWE ASSOCIATES INC /MD/	13F	Company	6.6%	1,456,901	$22,553,000	—	31 Dec 2020	13F
D. E. Shaw & Co., Inc.	13F	Company	6.2%	1,382,133	$21,396,000	—	31 Dec 2020	13F
GOLDMAN SACHS GROUP INC	13F	Company	4.7%	1,054,762	$16,328,000	—	31 Dec 2020	13F
GEODE CAPITAL MANAGEMENT, LLC	13F	Company	4.7%	1,039,847	$16,096,000	—	31 Dec 2020	13F
Nuveen Asset Management, LLC	13F	Company	4.6%	1,027,588	$15,907,000	—	31 Dec 2020	13F
Laurion Capital Management LP	13F	Company	4.4%	980,464	$15,178,000	—	31 Dec 2020	13F
S.c.a. Candriam	13F	Individual	4.3%	951,578	$14,731,000	—	31 Dec 2020	13F
Hood River Capital Management LLC	13F	Company	4.2%	931,754	$14,424,000	—	31 Dec 2020	13F
NORTHERN TRUST CORP	13F	Company	3.5%	780,852	$12,087,000	—	31 Dec 2020	13F
MORGAN STANLEY	13F	Company	3.3%	742,913	$11,501,000	—	31 Dec 2020	13F
Fairmount Funds Management LLC	13F	Company	3.2%	702,351	$10,872,000	—	31 Dec 2020	13F
C WorldWide Group Holding A/S	13F	Company	2.7%	600,000	$9,288,000	—	31 Dec 2020	13F
TWO SIGMA ADVISERS, LP	13F	Company	2.3%	506,900	$7,847,000	—	31 Dec 2020	13F
Granahan Investment Management, LLC	13F	Company	2.3%	502,542	$7,779,000	—	31 Dec 2020	13F
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	13F	Company	2.1%	467,069	$7,231,000	—	31 Dec 2020	13F
SUSQUEHANNA INTERNATIONAL GROUP, LLP	13F	Company	1.8%	401,123	$6,209,000	—	31 Dec 2020	13F
MACQUARIE GROUP LTD	13F	Company	1.7%	381,332	$5,903,000	—	31 Dec 2020	13F
BALYASNY ASSET MANAGEMENT L.P.	13F	Company	1.6%	362,505	$5,612,000	—	31 Dec 2020	13F
AMI ASSET MANAGEMENT CORP	13F	Company	1.6%	357,349	$5,532,000	—	31 Dec 2020	13F
JPMORGAN CHASE & CO	13F	Company	1.5%	334,978	$5,186,000	—	31 Dec 2020	13F
Bank of New York Mellon Corp	13F	Company	1.5%	328,960	$5,093,000	—	31 Dec 2020	13F
Allianz Asset Management GmbH	13F	Company	1.4%	307,103	$4,754,000	—	31 Dec 2020	13F
CITADEL ADVISORS LLC	13F	Company	1.2%	277,075	$4,289,000	—	31 Dec 2020	13F
J. Goldman & Co LP	13F	Company	1.2%	261,729	$4,052,000	—	31 Dec 2020	13F
BARCLAYS PLC	13F	Company	1%	230,465	$3,569,000	—	31 Dec 2020	13F
MARSHALL WACE, LLP	13F	Company	0.98%	217,430	$3,366,000	—	31 Dec 2020	13F
CREDIT SUISSE AG/	13F	Company	0.96%	213,933	$3,312,000	—	31 Dec 2020	13F
Birchview Capital, LP	13F	Company	0.85%	188,000	$2,910,000	—	31 Dec 2020	13F
DEUTSCHE BANK AG\	13F	Company	0.76%	169,908	$2,631,000	—	31 Dec 2020	13F
BANK OF AMERICA CORP /DE/	13F	Company	0.75%	166,711	$2,581,000	—	31 Dec 2020	13F
WELLS FARGO & COMPANY/MN	13F	Company	0.72%	161,023	$2,493,000	—	31 Dec 2020	13F
FMR LLC	13F	Company	0.72%	160,610	$2,486,000	—	31 Dec 2020	13F
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM	13F	Company	0.7%	156,227	$2,418,000	—	31 Dec 2020	13F
DIMENSIONAL FUND ADVISORS LP	13F	Company	0.66%	146,603	$2,269,000	—	31 Dec 2020	13F
Phocas Financial Corp.	13F	Company	0.63%	140,867	$2,180,000	—	31 Dec 2020	13F
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	13F	Company	0.61%	135,335	$2,095,000	—	31 Dec 2020	13F
Altium Capital Management LLC	13F	Company	0.6%	133,951	$2,074,000	—	31 Dec 2020	13F

Institutional Holders of Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI) as of Q1 2021

As of 31 Mar 2021, Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI) was held by 163 institutional shareholders that filed Form 13F with the SEC. Together, they reported ownership of 59,160,795 shares. The largest 10 holders included BlackRock Inc., Palo Alto Investors LP, STATE STREET CORP, VANGUARD GROUP INC, ALKEON CAPITAL MANAGEMENT LLC, Delphi Management Partners VIII, L.L.C., WELLINGTON MANAGEMENT GROUP LLP, MORGAN STANLEY, RICE HALL JAMES & ASSOCIATES, LLC, and TWO SIGMA INVESTMENTS, LP. This page lists 163 institutional shareholders reporting positions in this security for the Q1 2021 filing period.

Investor	Option	Weight %	Change %	Value $	* Price	Shares	Share Change	Activity	Report Period

Compare Q1 2021 vs Q4 2020 Across Filers

Q4 2020 holders

165

Q1 2021 holders

163

Holder diff

-2

Investor	Q4 2020 Shares	Q1 2021 Shares	Share Diff	Share Chg %	Q4 2020 Value $	Q1 2021 Value $	Value Diff $	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.