Security key
45779A846
CUSIP: 45779A846
Security key
45779A846
Report period
Q4 2025
Institutions
44
Top holders
10
Broader feeds
Reporting periods
Recent filing periods:
Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.
| Holder | Source | Role / Reporting | Ownership % | Shares | Holdings Value | 12M Net Δ | As of | Details |
|---|---|---|---|---|---|---|---|---|
| MARSHALL WACE, LLP |
13D/G
13F
|
Company |
10%
|
28,103,699
|
$67,729,915 | $0 | 30 Sep 2025 | |
| Rosalind Advisors, Inc. |
13D/G
13F
|
Company |
9.2%
|
10,987,104
|
$19,557,045 | $0 | 31 Dec 2025 | |
| Michael A. Lawless |
13D/G
|
— |
8.6%
|
3,614,731
|
$8,711,502 | $0 | 26 Jun 2025 | |
| Aberdeen Group plc |
13F
13D/G
|
Company |
7.5%
from 13D/G
|
2,481,117
|
$5,979,492 | — | 30 Sep 2025 | |
| ORBIMED ADVISORS LLC |
13D/G
13F
|
Company |
7.4%
|
3,133,405
|
$5,577,461 | +$1,780,000 | 31 Dec 2025 | |
| Parkman Healthcare Partners LLC |
13F
13D/G
|
Company |
5.8%
from 13D/G
|
2,440,633
|
$5,881,926 | — | 30 Sep 2025 | |
| Nantahala Capital Partners Limited Partnership |
13D/G
|
— |
5.7%
|
2,418,016
|
$5,827,419 | $0 | 30 Sep 2025 | |
| Craig Shore |
13D/G
3/4/5
|
CFO and CAO |
3.5%
|
1,484,505
|
$3,577,657 | $0 | 26 Jun 2025 | |
| Nantahala Capital Management, LLC |
13F
|
Company |
7%
|
3,376,484
|
$8,137,327 | — | 30 Sep 2025 | |
| Velan Capital Investment Management LP |
13F
|
Company |
4.4%
|
2,143,698
|
$5,166,312 | — | 30 Sep 2025 | |
| Soleus Capital Management, L.P. |
13F
|
Company |
3%
|
1,470,934
|
$3,544,951 | — | 30 Sep 2025 | |
| Ghisallo Capital Management LLC |
13F
|
Company |
1.9%
|
921,587
|
$2,221,025 | — | 30 Sep 2025 | |
| PURA VIDA INVESTMENTS, LLC |
13F
|
Company |
0.93%
|
450,517
|
$1,085,746 | — | 30 Sep 2025 | |
| Huntleigh Advisors, Inc. |
13F
|
Company |
0.55%
|
264,004
|
$636,250 | — | 30 Sep 2025 | |
| Affiance Financial, LLC |
13F
|
Company |
0.52%
|
250,370
|
$603,392 | — | 30 Sep 2025 | |
| INGALLS & SNYDER LLC |
13F
|
Company |
0.47%
|
225,002
|
$542,000 | — | 30 Sep 2025 | |
| MILLENNIUM MANAGEMENT LLC |
13F
|
Company |
0.31%
|
147,423
|
$355,289 | — | 30 Sep 2025 | |
| Schonfeld Strategic Advisors LLC |
13F
|
Company |
0.18%
|
86,092
|
$207,480 | — | 30 Sep 2025 | |
| MORGAN STANLEY |
13F
|
Company |
0.18%
|
86,011
|
$207,286 | — | 30 Sep 2025 | |
| IRONWOOD INVESTMENT MANAGEMENT LLC |
13F
|
Company |
0.13%
|
61,579
|
$148,405 | — | 30 Sep 2025 | |
| COURIER CAPITAL LLC |
13F
|
Company |
0.11%
|
55,000
|
$132,550 | — | 30 Sep 2025 | |
| BlackRock, Inc. |
13F
|
Company |
0.11%
|
53,714
|
$129,451 | — | 30 Sep 2025 | |
| VESTIA PERSONAL WEALTH ADVISORS |
13F
|
Company |
0.09%
|
42,425
|
$102,244 | — | 30 Sep 2025 | |
| CITADEL ADVISORS LLC |
13F
|
Company |
0.08%
|
37,954
|
$91,469 | — | 30 Sep 2025 | |
| NORTHERN TRUST CORP |
13F
|
Company |
0.07%
|
33,572
|
$80,909 | — | 30 Sep 2025 | |
| COMMONWEALTH EQUITY SERVICES, LLC |
13F
|
Company |
0.07%
|
32,550
|
$78,000 | — | 30 Sep 2025 | |
| Mesirow Financial Investment Management, Inc. |
13F
|
Company |
0.06%
|
30,000
|
$72,300 | — | 30 Sep 2025 | |
| Uniting Wealth Partners, LLC |
13F
|
Company |
0.04%
|
21,066
|
$50,769 | — | 30 Sep 2025 | |
| HOLLENCREST CAPITAL MANAGEMENT |
13F
|
Company |
0.04%
|
20,000
|
$48,200 | — | 30 Sep 2025 | |
| Creative Planning |
13F
|
Company |
0.04%
|
19,569
|
$47,161 | — | 30 Sep 2025 | |
| GEODE CAPITAL MANAGEMENT, LLC |
13F
|
Company |
0.04%
|
18,244
|
$43,968 | — | 30 Sep 2025 | |
| Avestar Capital, LLC |
13F
|
Company |
0.03%
|
15,000
|
$36,150 | — | 30 Sep 2025 | |
| Pallas Capital Advisors LLC |
13F
|
Company |
0.02%
|
11,000
|
$26,510 | — | 30 Sep 2025 | |
| BROWN ADVISORY INC |
13F
|
Company |
0.02%
|
10,000
|
$24,100 | — | 30 Sep 2025 | |
| McKinley Carter Wealth Services, Inc. |
13F
|
Company |
0.02%
|
10,000
|
$24,100 | — | 30 Sep 2025 | |
| AdvisorNet Financial, Inc |
13F
|
Company |
0.02%
|
8,783
|
$21,167 | — | 30 Sep 2025 | |
| GROUP ONE TRADING LLC |
13F
|
Company |
0.01%
|
4,000
|
$9,640 | — | 30 Sep 2025 | |
| Farther Finance Advisors, LLC |
13F
|
Company |
0%
|
1,000
|
$2,410 | — | 30 Sep 2025 | |
| BANK OF AMERICA CORP /DE/ |
13F
|
Company |
0%
|
608
|
$1,465 | — | 30 Sep 2025 | |
| SIMPLEX TRADING, LLC |
13F
|
Company |
0%
|
462
|
$1,000 | — | 30 Sep 2025 | |
| SBI Securities Co., Ltd. |
13F
|
Company |
0%
|
230
|
$554 | — | 30 Sep 2025 | |
| Global Retirement Partners, LLC |
13F
|
Company |
0%
|
27
|
$65 | — | 30 Sep 2025 | |
| BELLEVUE ASSET MANAGEMENT, LLC |
13F
|
Company |
0%
|
25
|
$1,855 | — | 30 Sep 2025 | |
| Koesten, Hirschmann & Crabtree, INC. |
13F
|
Company |
0%
|
2
|
$5 | — | 30 Sep 2025 | |
| Thomas J. Kester |
3/4/5
|
Director |
—
mixed-class rows
|
477,614
mixed-class rows
|
$1,105,160 | +$74,998 | 15 Sep 2025 | |
| Kathryn Arnold |
3/4/5
|
Director |
—
mixed-class rows
|
414,308
mixed-class rows
|
$584,957 | — | 30 Dec 2025 | |
| Patrick Verta |
3/4/5
|
EVP Clinical/Medical Affairs |
—
mixed-class rows
|
428,813
mixed-class rows
|
$578,187 | — | 07 Jan 2025 | |
| Campbell Rogers |
3/4/5
|
Director |
—
mixed-class rows
|
33,709
mixed-class rows
|
$70,761 | — | 13 Oct 2021 |
| Investor | Option | Weight % | Change % | Value $ | * Price | Shares | Share Change | Activity | Report Period |
|---|
| Investor | Q3 2025 Shares | Q4 2025 Shares | Share Diff | Share Chg % | Q3 2025 Value $ | Q4 2025 Value $ | Value Diff $ | Value Chg % |
|---|
Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).