| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 10% | +24% | $364,034,431 | +$93,724,350 | 14,555,555 | +35% | Avoro Capital Advisors LLC | 31 Dec 2025 |
| FMR LLC | 12% | +23% | $275,104,823 | +$52,642,399 | 10,999,793 | +24% | FMR LLC | 30 Jan 2026 |
| Adage Capital Management, L.P. | 7.5% | +20% | $243,348,750 | +$39,576,000 | 10,035,000 | +19% | Adage Capital Management, L.P. | 30 Sep 2025 |
| General Atlantic Cooperatief U.A. | 5% | -23% | $180,192,368 | -$56,624,900 | 7,366,818 | -24% | General Atlantic Cooperatief U.A. | 25 Nov 2025 |
As of 31 Dec 2025, 146 institutional investors reported holding 143,756,351 shares of Centessa Pharmaceuticals plc - Ordinary shares, nominal value 0.002 GBP per share (CNTA). This represents 98% of the company’s total 145,993,531 outstanding shares.
The largest institutional shareholders of Centessa Pharmaceuticals plc - Ordinary shares, nominal value 0.002 GBP per share (CNTA) together control 82% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Medicxi Ventures Management (Jersey) Ltd | 14% | 19,963,157 | 0% | 60% | $499,278,557 |
| Avoro Capital Advisors LLC | 10% | 14,555,555 | +35% | 3.6% | $364,034,431 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 7.7% | 11,281,741 | +12% | 0.43% | $282,156,342 |
| Index Venture Life Associates VI Ltd | 6.8% | 9,961,789 | 0% | 100% | $249,144,343 |
| FMR LLC | 6.1% | 8,961,939 | +43% | 0.01% | $224,138,094 |
| GENERAL ATLANTIC, L.P. | 4.2% | 6,117,715 | -37% | 5.3% | $153,004,052 |
| FARALLON CAPITAL MANAGEMENT LLC | 3.7% | 5,377,068 | +24% | 0.78% | $134,480,471 |
| TCG Crossover Management, LLC | 2.9% | 4,286,480 | +37% | 3.5% | $107,204,865 |
| JANUS HENDERSON GROUP PLC | 2.8% | 4,093,608 | -24% | 0.05% | $102,393,318 |
| Siren, L.L.C. | 2.8% | 4,027,517 | +25% | 3% | $100,728,200 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.7% | 3,927,343 | -18% | 0.01% | $98,223,000 |
| EcoR1 Capital, LLC | 2.1% | 3,115,000 | +466% | 3.6% | $77,906,150 |
| PERCEPTIVE ADVISORS LLC | 2% | 2,917,634 | -5.9% | 1.3% | $72,970,026 |
| FRANKLIN RESOURCES INC | 1.6% | 2,368,381 | -7.4% | 0.01% | $59,233,201 |
| FEDERATED HERMES, INC. | 1.6% | 2,342,139 | +34% | 0.1% | $58,576,896 |
| First Light Asset Management, LLC | 1.6% | 2,278,940 | -37% | 4.4% | $56,996,289 |
| BRAIDWELL LP | 1.5% | 2,188,320 | 1.8% | $54,729,883 | |
| Deep Track Capital, LP | 1.4% | 2,000,000 | 1.1% | $50,020,000 | |
| MILLENNIUM MANAGEMENT LLC | 1.3% | 1,870,671 | +107% | 0.03% | $46,785,482 |
| RTW INVESTMENTS, LP | 1.2% | 1,790,837 | -22% | 0.45% | $44,788,833 |
| MAVERICK CAPITAL LTD | 1.1% | 1,643,724 | 0.44% | $41,109,537 | |
| Foresite Capital Management VI LLC | 0.93% | 1,364,019 | +3.8% | 10% | $34,114,115 |
| Cormorant Asset Management, LP | 0.91% | 1,325,000 | -31% | 1.9% | $33,138,250 |
| Capital World Investors | 0.79% | 1,158,699 | +69% | 0% | $28,979,062 |
| STEMPOINT CAPITAL LP | 0.79% | 1,154,114 | +76% | 5% | $28,864,391 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 143,756,351 | $3,595,234,186 | +$388,743,626 | $25.01 | 146 |
| 2025 Q3 | 128,332,503 | $3,111,987,564 | +$147,803,679 | $24.25 | 124 |
| 2025 Q2 | 123,569,478 | $1,623,678,828 | -$30,690,539 | $13.14 | 117 |
| 2025 Q1 | 124,913,742 | $1,797,461,231 | -$6,439,160 | $14.38 | 130 |
| 2024 Q4 | 124,413,136 | $2,083,915,345 | +$72,898,202 | $16.75 | 114 |
| 2024 Q3 | 108,571,980 | $1,737,489,847 | +$315,516,266 | $15.99 | 101 |
| 2024 Q2 | 86,506,981 | $781,158,600 | +$108,671,569 | $9.03 | 79 |
| 2024 Q1 | 74,395,267 | $840,663,455 | +$66,659,727 | $11.30 | 69 |
| 2023 Q4 | 71,279,084 | $567,382,245 | +$15,317,885 | $7.96 | 56 |
| 2023 Q3 | 72,578,425 | $469,582,127 | +$14,480,766 | $6.47 | 46 |
| 2023 Q2 | 70,339,619 | $435,403,089 | +$25,413,534 | $6.19 | 43 |
| 2023 Q1 | 66,895,058 | $257,540,618 | +$13,125,714 | $3.85 | 42 |
| 2022 Q4 | 62,684,642 | $194,353,719 | +$5,918,047 | $3.10 | 41 |
| 2022 Q3 | 71,808,783 | $288,649,039 | -$842,289 | $4.02 | 41 |
| 2022 Q2 | 71,775,040 | $349,577,531 | -$37,633,222 | $4.87 | 40 |
| 2022 Q1 | 74,581,035 | $669,057,512 | +$23,146,015 | $8.97 | 40 |
| 2021 Q4 | 71,873,880 | $807,766,000 | +$18,577,946 | $11.26 | 46 |
| 2021 Q3 | 52,983,439 | $881,813,000 | +$147,088,157 | $16.70 | 38 |
| 2021 Q2 | 47,409,892 | $1,045,414,000 | +$1,045,413,999 | $22.21 | 49 |