| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 8.1% | $262,095,940 | 10,808,080 | Avoro Capital Advisors LLC | 30 Sep 2025 | |||
| Adage Capital Management, L.P. | 7.5% | +20% | $243,348,750 | +$39,576,000 | 10,035,000 | +19% | Adage Capital Management, L.P. | 30 Sep 2025 |
| General Atlantic Cooperatief U.A. | 5% | -23% | $180,192,368 | -$56,624,900 | 7,366,818 | -24% | General Atlantic Cooperatief U.A. | 25 Nov 2025 |
| FMR LLC | 7% | $152,223,143 | 6,277,243 | FMR LLC | 30 Sep 2025 |
As of 30 Sep 2025, 124 institutional investors reported holding 128,332,503 shares of Centessa Pharmaceuticals plc - Ordinary shares, par value 0.002 GBP per share (CNTA). This represents 87% of the company’s total 147,336,360 outstanding shares.
The largest institutional shareholders of Centessa Pharmaceuticals plc - Ordinary shares, par value 0.002 GBP per share (CNTA) together control 77% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Medicxi Ventures Management (Jersey) Ltd | 14% | 19,963,157 | 0% | 65% | $484,106,557 |
| Avoro Capital Advisors LLC | 7.3% | 10,808,080 | +116% | 3.4% | $262,095,940 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6.8% | 10,035,000 | +19% | 0.39% | $243,348,750 |
| Index Venture Life Associates VI Ltd | 6.8% | 9,961,789 | 0% | 100% | $241,573,383 |
| GENERAL ATLANTIC, L.P. | 6.6% | 9,681,818 | 0% | 7% | $234,784,087 |
| FMR LLC | 4.3% | 6,277,243 | +64% | 0.01% | $152,223,143 |
| JANUS HENDERSON GROUP PLC | 3.7% | 5,408,199 | -17% | 0.06% | $131,075,198 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.3% | 4,804,056 | -19% | 0.01% | $116,499,000 |
| FARALLON CAPITAL MANAGEMENT LLC | 2.9% | 4,331,318 | -4.4% | 0.59% | $105,034,462 |
| First Light Asset Management, LLC | 2.5% | 3,635,816 | -15% | 8.3% | $88,168,538 |
| Siren, L.L.C. | 2.2% | 3,227,517 | -6.7% | 3.1% | $78,267,287 |
| TCG Crossover Management, LLC | 2.1% | 3,136,480 | +8.5% | 3.7% | $76,059,640 |
| PERCEPTIVE ADVISORS LLC | 2.1% | 3,100,902 | +170% | 2.2% | $75,196,874 |
| Commodore Capital LP | 1.9% | 2,850,000 | -14% | 3.4% | $69,112,500 |
| FRANKLIN RESOURCES INC | 1.7% | 2,558,414 | +0.58% | 0.02% | $62,041,541 |
| RTW INVESTMENTS, LP | 1.6% | 2,291,747 | +50% | 0.68% | $55,574,865 |
| Cormorant Asset Management, LP | 1.3% | 1,925,000 | -7.7% | 3.2% | $46,681,250 |
| FEDERATED HERMES, INC. | 1.2% | 1,749,650 | 0.07% | $42,429,013 | |
| Foresite Capital Management VI LLC | 0.89% | 1,314,019 | +4.8% | 12% | $31,864,961 |
| MORGAN STANLEY | 0.76% | 1,124,445 | -37% | 0% | $27,267,792 |
| Affinity Asset Advisors, LLC | 0.75% | 1,107,162 | +23% | 2.5% | $26,848,679 |
| AMERICAN CENTURY COMPANIES INC | 0.74% | 1,096,704 | -3% | 0.01% | $26,595,131 |
| Point72 Asset Management, L.P. | 0.73% | 1,072,665 | -59% | 0.06% | $26,012,126 |
| MILLENNIUM MANAGEMENT LLC | 0.61% | 902,268 | -46% | 0.02% | $21,879,999 |
| Octagon Capital Advisors LP | 0.56% | 830,000 | -19% | 3.1% | $20,127,500 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 268,380 | $6,711,914 | +$4,709,421 | $25.01 | 5 |
| 2025 Q3 | 128,332,503 | $3,111,987,564 | +$147,803,679 | $24.25 | 124 |
| 2025 Q2 | 123,569,478 | $1,623,678,828 | -$30,690,539 | $13.14 | 117 |
| 2025 Q1 | 124,913,742 | $1,797,461,231 | -$6,439,160 | $14.38 | 130 |
| 2024 Q4 | 124,413,136 | $2,083,915,345 | +$72,898,202 | $16.75 | 114 |
| 2024 Q3 | 108,571,980 | $1,737,489,847 | +$315,516,266 | $15.99 | 101 |
| 2024 Q2 | 86,506,981 | $781,158,600 | +$108,671,569 | $9.03 | 79 |
| 2024 Q1 | 74,395,267 | $840,663,455 | +$66,659,727 | $11.30 | 69 |
| 2023 Q4 | 71,279,084 | $567,382,245 | +$15,317,885 | $7.96 | 56 |
| 2023 Q3 | 72,578,425 | $469,582,127 | +$14,480,766 | $6.47 | 46 |
| 2023 Q2 | 70,339,619 | $435,403,089 | +$25,413,534 | $6.19 | 43 |
| 2023 Q1 | 66,895,058 | $257,540,618 | +$13,125,714 | $3.85 | 42 |
| 2022 Q4 | 62,684,642 | $194,353,719 | +$5,918,047 | $3.10 | 41 |
| 2022 Q3 | 71,808,783 | $288,649,039 | -$842,289 | $4.02 | 41 |
| 2022 Q2 | 71,775,040 | $349,577,531 | -$37,633,222 | $4.87 | 40 |
| 2022 Q1 | 74,581,035 | $669,057,512 | +$23,146,015 | $8.97 | 40 |
| 2021 Q4 | 71,873,880 | $807,766,000 | +$18,577,946 | $11.26 | 46 |
| 2021 Q3 | 52,983,439 | $881,813,000 | +$147,088,157 | $16.70 | 38 |
| 2021 Q2 | 47,409,892 | $1,045,414,000 | +$1,045,413,999 | $22.21 | 49 |