| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 10.2% | +6% | $230,991,369 | +$16,837,739 | 12,254,119 | +7.9% | Jennison Associates LLC | 30 Sep 2025 |
| PRUDENTIAL FINANCIAL INC | 10.1% | $176,322,532 | 11,954,070 | PRUDENTIAL FINANCIAL INC | 31 Mar 2025 | |||
| Frazier Life Sciences VIII, L.P. | 7.5% | $130,399,321 | 8,943,712 | Patrick J. Heron | 18 Aug 2025 | |||
| Polar Capital Holdings Plc | 4.2% | -24% | $75,147,145 | -$25,517,045 | 5,006,472 | -25% | Polar Capital Holdings Plc | 30 Jun 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 125,769,778 | $2,369,520,876 | -$12,687,593 | $18.85 | 233 |
| 2025 Q2 | 127,080,415 | $1,781,069,063 | +$21,637,125 | $14.02 | 228 |
| 2025 Q1 | 125,020,441 | $1,954,466,256 | -$63,284,061 | $15.64 | 239 |
| 2024 Q4 | 128,710,441 | $1,792,934,402 | +$13,789,213 | $13.93 | 206 |
| 2024 Q3 | 128,641,664 | $1,198,282,493 | +$15,921,001 | $9.3 | 187 |
| 2024 Q2 | 126,503,507 | $1,176,619,915 | +$9,242,287 | $9.3 | 184 |
| 2024 Q1 | 124,986,945 | $1,238,517,575 | +$285,414,998 | $9.91 | 166 |
| 2023 Q4 | 101,272,913 | $327,119,655 | +$79,248,549 | $3.23 | 130 |
| 2023 Q3 | 67,159,664 | $356,705,615 | -$26,597,323 | $5.31 | 131 |
| 2023 Q2 | 71,766,867 | $683,988,878 | -$5,745,956 | $9.53 | 135 |
| 2023 Q1 | 71,600,840 | $787,595,702 | +$44,255,428 | $11 | 141 |
| 2022 Q4 | 65,632,382 | $971,340,873 | +$87,400,990 | $14.8 | 138 |
| 2022 Q3 | 59,389,299 | $1,134,920,691 | +$194,978,652 | $19.11 | 138 |
| 2022 Q2 | 49,075,739 | $1,045,833,934 | +$17,642,019 | $21.31 | 112 |
| 2022 Q1 | 48,307,139 | $929,780,885 | -$136,426,148 | $19.26 | 106 |
| 2021 Q4 | 46,348,278 | $961,255,152 | -$1,852,441 | $20.74 | 89 |
| 2021 Q3 | 45,697,453 | $1,091,410,573 | +$4,816,184 | $23.89 | 103 |
| 2021 Q2 | 45,474,760 | $1,240,848,739 | -$38,040,013 | $27.29 | 100 |
| 2021 Q1 | 46,841,365 | $1,354,985,371 | +$170,660,745 | $28.93 | 93 |
| 2020 Q4 | 40,973,719 | $1,152,598,120 | +$138,537,380 | $28.13 | 78 |
| 2020 Q3 | 34,766,158 | $1,018,651,387 | +$28,894,471 | $29.3 | 62 |
| 2020 Q2 | 33,776,828 | $1,021,408,758 | +$33,104,690 | $30.24 | 55 |
| 2020 Q1 | 32,683,658 | $973,975,747 | +$973,295,747 | $29.8 | 49 |