| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 10% | +6% | $230,991,369 | +$16,837,739 | 12,254,119 | +7.9% | Jennison Associates LLC | 30 Sep 2025 |
| PRUDENTIAL FINANCIAL INC | 10% | $176,322,532 | 11,954,070 | PRUDENTIAL FINANCIAL INC | 31 Mar 2025 | |||
| Frazier Life Sciences VIII, L.P. | 7.5% | $130,399,321 | 8,943,712 | Patrick J. Heron | 18 Aug 2025 | |||
| Polar Capital Holdings Plc | 4.2% | -24% | $75,147,145 | -$25,517,045 | 5,006,472 | -25% | Polar Capital Holdings Plc | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 10% | 12,254,119 | +10% | 0.13% | $230,990,144 |
| Rubric Capital Management LP | 8.9% | 10,749,457 | 0% | 2.7% | $202,627,264 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 8.7% | 10,478,000 | -9.2% | 6% | $197,510,300 |
| Frazier Life Sciences Management, L.P. | 8.2% | 9,874,511 | 0% | 5.6% | $186,134,532 |
| BlackRock, Inc. | 7.1% | 8,573,995 | +0.48% | 0% | $161,619,806 |
| VANGUARD GROUP INC | 5.9% | 7,146,090 | +1.4% | 0% | $134,703,797 |
| Polar Capital Holdings Plc | 4.4% | 5,298,754 | +5.8% | 0.48% | $99,881,513 |
| STATE STREET CORP | 3.9% | 4,641,315 | +2.5% | 0% | $87,488,788 |
| GILDER GAGNON HOWE & CO LLC | 3.7% | 4,429,108 | +6.6% | 0.85% | $83,488,686 |
| MORGAN STANLEY | 3.6% | 4,276,394 | -0.88% | 0% | $80,610,030 |
| UBS Group AG | 2.5% | 2,948,438 | +0.36% | 0.01% | $55,578,057 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.2% | 2,606,465 | +0.93% | 0% | $49,139,527 |
| JANUS HENDERSON GROUP PLC | 2% | 2,398,031 | +5.9% | 0.02% | $45,178,904 |
| FRANKLIN RESOURCES INC | 1.9% | 2,311,019 | -15% | 0.01% | $43,562,708 |
| Pivotal bioVenture Partners Investment Advisor LLC | 1.8% | 2,120,508 | 0% | 23% | $39,971,576 |
| D. E. Shaw & Co., Inc. | 1.8% | 2,118,713 | -2% | 0.03% | $39,937,740 |
| Perpetual Ltd | 1.7% | 2,024,606 | +7534% | 0.47% | $38,163,823 |
| Ensign Peak Advisors, Inc | 1.7% | 1,993,055 | -0.42% | 0.06% | $37,569,087 |
| GOLDMAN SACHS GROUP INC | 1.5% | 1,804,988 | -4.5% | 0% | $34,024,024 |
| AMERICAN CENTURY COMPANIES INC | 1.4% | 1,662,470 | -3.6% | 0.02% | $31,337,590 |
| Nuveen, LLC | 1.1% | 1,370,356 | +79% | 0.01% | $25,831,211 |
| GW&K Investment Management, LLC | 0.98% | 1,172,041 | -15% | 0.2% | $22,093,000 |
| Driehaus Capital Management LLC | 0.91% | 1,097,004 | +1% | 0.15% | $20,678,525 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.83% | 999,434 | +3.6% | 0% | $18,839,331 |
| NORTHERN TRUST CORP | 0.78% | 940,202 | +1.2% | 0% | $17,722,808 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 282,482 | $8,200,136 | +$6,361,694 | $29.04 | 8 |
| 2025 Q3 | 125,769,778 | $2,369,520,876 | -$12,687,593 | $18.85 | 233 |
| 2025 Q2 | 127,080,415 | $1,781,069,063 | +$21,637,125 | $14.02 | 228 |
| 2025 Q1 | 125,020,441 | $1,954,466,256 | -$63,284,061 | $15.64 | 239 |
| 2024 Q4 | 128,710,441 | $1,792,934,402 | +$13,789,213 | $13.93 | 206 |
| 2024 Q3 | 128,641,664 | $1,198,282,493 | +$15,921,001 | $9.30 | 187 |
| 2024 Q2 | 126,503,507 | $1,176,619,915 | +$9,242,287 | $9.30 | 184 |
| 2024 Q1 | 124,986,945 | $1,238,517,575 | +$285,414,998 | $9.91 | 166 |
| 2023 Q4 | 101,272,913 | $327,119,655 | +$79,248,549 | $3.23 | 130 |
| 2023 Q3 | 67,159,664 | $356,705,615 | -$26,597,323 | $5.31 | 131 |
| 2023 Q2 | 71,766,867 | $683,988,878 | -$5,745,956 | $9.53 | 135 |
| 2023 Q1 | 71,600,840 | $787,595,702 | +$44,255,428 | $11.00 | 141 |
| 2022 Q4 | 65,632,382 | $971,340,873 | +$87,400,990 | $14.80 | 138 |
| 2022 Q3 | 59,389,299 | $1,134,920,691 | +$194,978,652 | $19.11 | 138 |
| 2022 Q2 | 49,075,739 | $1,045,833,934 | +$17,642,019 | $21.31 | 112 |
| 2022 Q1 | 48,307,139 | $929,780,885 | -$136,426,148 | $19.26 | 106 |
| 2021 Q4 | 46,348,278 | $961,255,152 | -$1,852,441 | $20.74 | 89 |
| 2021 Q3 | 45,697,453 | $1,091,410,573 | +$4,816,184 | $23.89 | 103 |
| 2021 Q2 | 45,474,760 | $1,240,848,739 | -$38,040,013 | $27.29 | 100 |
| 2021 Q1 | 46,841,365 | $1,354,985,371 | +$170,660,745 | $28.93 | 93 |
| 2020 Q4 | 40,973,719 | $1,152,598,120 | +$138,537,380 | $28.13 | 78 |
| 2020 Q3 | 34,766,158 | $1,018,651,387 | +$28,894,471 | $29.30 | 62 |
| 2020 Q2 | 33,776,828 | $1,021,408,758 | +$33,104,690 | $30.24 | 55 |
| 2020 Q1 | 32,683,658 | $973,975,747 | +$973,295,747 | $29.80 | 49 |