| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 15% | $266,406,847 | 6,907,100 | FMR LLC | 30 Jun 2025 | |||
| Fairmount Funds Management LLC | 10% | 0% | $456,430,807 | +$20,390,674 | 6,047,027 | +4.7% | Peter Evan Harwin | 22 Jan 2026 |
| WELLINGTON MANAGEMENT GROUP LLP | 8.7% | -17% | $374,980,215 | -$10,946,319 | 4,746,585 | -2.8% | Wellington Management Group LLP | 31 Dec 2025 |
| VANGUARD GROUP INC | 5.2% | $215,709,127 | 2,857,824 | The Vanguard Group | 31 Dec 2025 | |||
| RTW INVESTMENTS, LP | 6% | $102,463,025 | 2,712,097 | RTW Investments, LP | 31 Dec 2024 | |||
| BlackRock, Inc. | 5.5% | $109,396,539 | 2,518,725 | BlackRock, Inc. | 30 Jun 2025 | |||
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4.7% | $85,757,284 | 2,158,502 | DRIEHAUS CAPITAL MANAGEMENT LLC | 30 Sep 2025 |
As of 31 Dec 2025, 135 institutional investors reported holding 21,568,459 shares of Apogee Therapeutics, Inc. - Common Stock (APGE). This represents 40% of the company’s total 54,558,448 outstanding shares.
The largest institutional shareholders of Apogee Therapeutics, Inc. - Common Stock (APGE) together control 36% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| BlackRock, Inc. | 6.9% | 3,783,994 | +41% | 0% | $285,615,865 |
| VANGUARD GROUP INC | 5.2% | 2,857,824 | +27% | 0% | $215,708,556 |
| STATE STREET CORP | 3.1% | 1,690,186 | +2.1% | 0% | $127,575,239 |
| JPMORGAN CHASE & CO | 2.5% | 1,373,066 | +21% | 0.01% | $103,639,021 |
| Affinity Asset Advisors, LLC | 2.3% | 1,234,926 | +5.2% | 6.7% | $93,212,214 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.9% | 1,059,085 | +19% | 0% | $79,957,396 |
| UBS Group AG | 1.8% | 974,826 | +22% | 0.01% | $73,579,866 |
| MORGAN STANLEY | 1.6% | 890,264 | +91% | 0% | $67,197,243 |
| Remedium Capital Partners, LLC | 1.1% | 583,591 | 0% | 26% | $44,050,000 |
| JENNISON ASSOCIATES LLC | 1.1% | 578,627 | 0.03% | $43,674,766 | |
| GOLDMAN SACHS GROUP INC | 1% | 565,410 | -5.7% | 0.01% | $42,677,147 |
| Sofinnova Investments, Inc. | 0.98% | 534,845 | -5.4% | 1.7% | $40,370,101 |
| First Turn Management, LLC | 0.87% | 474,839 | +18% | 4.1% | $35,840,848 |
| FRANKLIN RESOURCES INC | 0.83% | 451,002 | -38% | 0.01% | $34,041,593 |
| EVENTIDE ASSET MANAGEMENT, LLC | 0.8% | 436,015 | 0.51% | $32,910,412 | |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.7% | 381,362 | +19% | 0% | $28,785,204 |
| Pictet Asset Management Holding SA | 0.57% | 312,883 | 0.02% | $23,616,409 | |
| LOOMIS SAYLES & CO L P | 0.47% | 255,439 | 0.02% | $19,280,535 | |
| Candriam S.C.A. | 0.35% | 191,318 | +52% | 0.07% | $14,441,297 |
| BARCLAYS PLC | 0.24% | 133,193 | -79% | 0% | $10,053,408 |
| TD Asset Management Inc | 0.24% | 129,290 | +55% | 0.01% | $9,758,809 |
| FEDERATED HERMES, INC. | 0.23% | 127,931 | 0.02% | $9,656,232 | |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.23% | 127,629 | -2.9% | 0.02% | $9,633,438 |
| Capital World Investors | 0.23% | 127,618 | 0% | 0% | $9,632,607 |
| KENNEDY CAPITAL MANAGEMENT LLC | 0.23% | 124,979 | +0.75% | 0.2% | $9,433,415 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 21,568,459 | $1,628,068,058 | +$293,313,098 | $75.48 | 135 |
| 2025 Q3 | 59,584,020 | $2,367,665,644 | +$56,490,773 | $39.73 | 173 |
| 2025 Q2 | 57,837,483 | $2,511,890,310 | -$147,322,983 | $43.43 | 180 |
| 2025 Q1 | 61,488,037 | $2,301,755,351 | +$131,273,115 | $37.36 | 165 |
| 2024 Q4 | 57,873,775 | $2,621,627,227 | +$63,332,544 | $45.30 | 156 |
| 2024 Q3 | 56,092,373 | $3,292,239,932 | +$134,148,823 | $58.74 | 137 |
| 2024 Q2 | 54,152,101 | $2,130,892,019 | -$9,800,456 | $39.35 | 137 |
| 2024 Q1 | 52,915,146 | $3,516,219,943 | +$778,331,224 | $66.45 | 137 |
| 2023 Q4 | 41,768,396 | $1,163,676,392 | +$48,111,524 | $27.94 | 85 |
| 2023 Q3 | 40,111,211 | $848,653,526 | +$848,653,497 | $21.30 | 73 |