| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 15% | $266,406,847 | 6,907,100 | FMR LLC | 30 Jun 2025 | |||
| Fairmount Funds Management LLC | 10% | 0% | $456,430,807 | +$20,390,674 | 6,047,027 | +4.7% | Peter Evan Harwin | 22 Jan 2026 |
| WELLINGTON MANAGEMENT GROUP LLP | 11% | +29% | $188,420,081 | +$41,633,847 | 4,885,146 | +28% | Wellington Management Group LLP | 31 Jul 2025 |
| RTW INVESTMENTS, LP | 6% | $102,463,025 | 2,712,097 | RTW Investments, LP | 31 Dec 2024 | |||
| BlackRock, Inc. | 5.5% | $109,396,539 | 2,518,725 | BlackRock, Inc. | 30 Jun 2025 | |||
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4.7% | $85,757,284 | 2,158,502 | DRIEHAUS CAPITAL MANAGEMENT LLC | 30 Sep 2025 |
As of 30 Sep 2025, 172 institutional investors reported holding 59,584,018 shares of Apogee Therapeutics, Inc. - Common Stock, $0.00001 par value (APGE). This represents 98% of the company’s total 60,530,801 outstanding shares.
The largest institutional shareholders of Apogee Therapeutics, Inc. - Common Stock, $0.00001 par value (APGE) together control 82% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| VR ADVISER, LLC | 14% | 8,493,321 | 0% | 19% | $337,439,643 |
| FMR LLC | 11% | 6,916,462 | +0.14% | 0.01% | $274,791,036 |
| WELLINGTON MANAGEMENT GROUP LLP | 7.8% | 4,723,701 | +24% | 0.03% | $187,672,640 |
| RTW INVESTMENTS, LP | 4.5% | 2,712,097 | 0% | 1.3% | $107,751,614 |
| BlackRock, Inc. | 4.4% | 2,686,026 | +4.8% | 0% | $106,715,814 |
| VANGUARD GROUP INC | 3.7% | 2,245,631 | +6.5% | 0% | $89,218,920 |
| Driehaus Capital Management LLC | 3.6% | 2,158,502 | -6.6% | 0.61% | $85,757,284 |
| Fairmount Funds Management LLC | 3.4% | 2,048,647 | 0% | 7.3% | $81,392,745 |
| STATE STREET CORP | 2.7% | 1,655,548 | +31% | 0% | $65,774,922 |
| Paradigm Biocapital Advisors LP | 2.5% | 1,521,757 | +59% | 1.8% | $60,459,406 |
| BRAIDWELL LP | 2.4% | 1,438,745 | -2.7% | 1.7% | $57,161,339 |
| ALLIANCEBERNSTEIN L.P. | 2.3% | 1,419,132 | +2.2% | 0.02% | $56,382,114 |
| PERCEPTIVE ADVISORS LLC | 2.2% | 1,351,989 | +14% | 1.6% | $53,714,523 |
| Affinity Asset Advisors, LLC | 1.9% | 1,173,426 | +70% | 4.3% | $46,620,215 |
| CITADEL ADVISORS LLC | 1.9% | 1,169,244 | +136% | 0.04% | $46,454,065 |
| JPMORGAN CHASE & CO | 1.9% | 1,137,731 | +1.1% | 0% | $45,202,052 |
| MERCER GLOBAL ADVISORS INC /ADV | 1.6% | 970,581 | +18% | 0.06% | $38,561,183 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.5% | 892,203 | +14% | 0% | $35,453,920 |
| UBS Group AG | 1.3% | 799,465 | +646% | 0.01% | $31,762,745 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.2% | 750,529 | -1.4% | 0% | $29,820,000 |
| FRANKLIN RESOURCES INC | 1.2% | 730,761 | -14% | 0.01% | $29,033,130 |
| BARCLAYS PLC | 1.1% | 642,316 | +5.5% | 0.01% | $25,519,215 |
| GOLDMAN SACHS GROUP INC | 0.99% | 599,616 | -9% | 0% | $23,822,744 |
| Jefferies Financial Group Inc. | 0.94% | 568,084 | -12% | 0.21% | $22,569,977 |
| Sofinnova Investments, Inc. | 0.93% | 565,417 | +642% | 1.4% | $22,464,017 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 157,836 | $11,915,276 | -$2,440,979 | $75.48 | 10 |
| 2025 Q3 | 59,584,018 | $2,367,665,565 | +$56,490,694 | $39.73 | 172 |
| 2025 Q2 | 57,837,483 | $2,511,890,310 | -$147,322,983 | $43.43 | 180 |
| 2025 Q1 | 61,488,037 | $2,301,755,351 | +$131,273,115 | $37.36 | 165 |
| 2024 Q4 | 57,873,775 | $2,621,627,227 | +$63,332,544 | $45.30 | 156 |
| 2024 Q3 | 56,092,373 | $3,292,239,932 | +$134,148,823 | $58.74 | 137 |
| 2024 Q2 | 54,152,101 | $2,130,892,019 | -$9,800,456 | $39.35 | 137 |
| 2024 Q1 | 52,915,146 | $3,516,219,943 | +$778,331,224 | $66.45 | 137 |
| 2023 Q4 | 41,768,396 | $1,163,676,392 | +$48,111,524 | $27.94 | 85 |
| 2023 Q3 | 40,111,211 | $848,653,526 | +$848,653,497 | $21.30 | 73 |