| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 10% | -30% | $33,797,548 | -$14,072,892 | 11,081,163 | -29% | FMR LLC | 30 Sep 2025 |
| Satter Muneer A | 7.2% | $36,032,262 | 10,444,134 | Satter Muneer A | 19 Nov 2025 | |||
| BlackRock, Inc. | 6.1% | $44,521,150 | 8,868,755 | BlackRock, Inc. | 31 Dec 2025 | |||
| VANGUARD GROUP INC | 5.3% | +8.2% | $17,797,092 | +$1,389,132 | 5,835,112 | +8.5% | The Vanguard Group | 30 Sep 2025 |
| Bain Capital Life Sciences Fund, L.P. | 4.9% | $9,973,231 | 5,249,069 | BCLS I Investco, LP | 31 Dec 2024 | |||
| Point72 Asset Management, L.P. | 0.1% | $181,317 | 95,430 | Point72 Asset Management, L.P. | 31 Mar 2025 |
As of 30 Sep 2025, 144 institutional investors reported holding 101,393,828 shares of Annexon, Inc. - Common Stock (ANNX). This represents 70% of the company’s total 145,389,426 outstanding shares.
The largest institutional shareholders of Annexon, Inc. - Common Stock (ANNX) together control 58% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 7.6% | 11,081,163 | -29% | 0% | $33,797,548 |
| BlackRock, Inc. | 5.4% | 7,899,008 | -0.8% | 0% | $24,091,974 |
| BVF INC/IL | 4.8% | 7,000,000 | 0% | 0.87% | $21,350,000 |
| Redmile Group, LLC | 4.3% | 6,300,644 | 0% | 1.9% | $19,216,964 |
| VANGUARD GROUP INC | 4% | 5,835,112 | +8.7% | 0% | $17,797,091 |
| Bain Capital Life Sciences Investors, LLC | 3.6% | 5,249,069 | 0% | 1.1% | $16,009,660 |
| Bellevue Group AG | 3.5% | 5,157,290 | 0% | 0.33% | $15,729,735 |
| MORGAN STANLEY | 2.1% | 3,029,848 | +264% | 0% | $9,241,037 |
| MILLENNIUM MANAGEMENT LLC | 1.9% | 2,822,823 | +12% | 0.01% | $8,609,610 |
| Woodline Partners LP | 1.8% | 2,638,275 | +150% | 0.04% | $8,046,739 |
| Opaleye Management Inc. | 1.8% | 2,600,000 | 1.1% | $7,930,000 | |
| Candriam S.C.A. | 1.7% | 2,534,230 | 0% | 0.04% | $7,729,402 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.7% | 2,436,944 | +6.7% | 0% | $7,434,061 |
| GOLDMAN SACHS GROUP INC | 1.7% | 2,406,432 | +48% | 0% | $7,339,618 |
| AMERIPRISE FINANCIAL INC | 1.5% | 2,192,354 | +1.2% | 0% | $6,686,681 |
| TFG Asset Management GP Ltd | 1.5% | 2,112,455 | -25% | 0.94% | $6,442,988 |
| STATE STREET CORP | 1.4% | 2,050,308 | +3.5% | 0% | $6,253,439 |
| SPHERA FUNDS MANAGEMENT LTD. | 1.2% | 1,794,387 | +1.7% | 1.3% | $5,472,880 |
| DEUTSCHE BANK AG\ | 1% | 1,504,349 | +194% | 0% | $4,588,264 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1% | 1,500,000 | 0.01% | $4,575,000 | |
| Balyasny Asset Management L.P. | 0.89% | 1,297,260 | 0.01% | $3,956,643 | |
| BANK OF AMERICA CORP /DE/ | 0.89% | 1,294,302 | -11% | 0% | $3,947,621 |
| J. Goldman & Co LP | 0.76% | 1,107,001 | 0.13% | $3,376,353 | |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 0.73% | 1,066,932 | -1.1% | 0.03% | $3,254,143 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0.67% | 980,285 | -0.73% | 0% | $2,989,869 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 1,632,141 | $8,195,286 | -$874,899 | $5.02 | 9 |
| 2025 Q3 | 101,393,828 | $309,259,133 | +$11,182,352 | $3.05 | 144 |
| 2025 Q2 | 99,449,067 | $238,679,312 | +$759,672 | $2.40 | 127 |
| 2025 Q1 | 99,491,910 | $192,036,870 | -$14,234,585 | $1.93 | 146 |
| 2024 Q4 | 111,907,572 | $574,088,227 | +$7,286,342 | $5.13 | 151 |
| 2024 Q3 | 109,990,075 | $651,286,147 | +$12,076,588 | $5.92 | 141 |
| 2024 Q2 | 107,381,777 | $526,166,969 | +$50,550,360 | $4.90 | 139 |
| 2024 Q1 | 94,762,361 | $679,439,424 | +$107,931,991 | $7.17 | 125 |
| 2023 Q4 | 80,514,496 | $365,538,892 | +$125,501,716 | $4.54 | 98 |
| 2023 Q3 | 53,312,574 | $125,814,682 | -$910,472 | $2.36 | 91 |
| 2023 Q2 | 53,372,682 | $187,869,879 | -$1,833,578 | $3.52 | 93 |
| 2023 Q1 | 53,953,057 | $207,583,535 | +$11,598,782 | $3.85 | 98 |
| 2022 Q4 | 47,049,561 | $243,269,266 | +$3,854,655 | $5.17 | 81 |
| 2022 Q3 | 46,270,615 | $285,949,000 | +$49,950,788 | $6.18 | 69 |
| 2022 Q2 | 38,409,280 | $144,864,000 | +$5,360,704 | $3.77 | 74 |
| 2022 Q1 | 38,555,259 | $105,261,060 | -$23,763,559 | $2.73 | 96 |
| 2021 Q4 | 38,766,276 | $445,683,894 | +$6,730,750 | $11.49 | 94 |
| 2021 Q3 | 38,055,922 | $708,635,015 | -$28,821,254 | $18.61 | 81 |
| 2021 Q2 | 38,854,536 | $873,668,672 | +$29,687,677 | $22.51 | 73 |
| 2021 Q1 | 37,426,974 | $1,040,768,344 | +$38,809,119 | $27.84 | 72 |
| 2020 Q4 | 36,208,873 | $904,277,496 | -$17,927,945 | $25.03 | 70 |
| 2020 Q3 | 34,842,574 | $1,039,585,431 | +$1,039,585,431 | $30.23 | 65 |