| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 20% | +37% | $18,349,040 | +$12,832,820 | 11,914,961 | +233% | BEHZAD AGHAZADEH | 28 Feb 2025 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 10% | $7,280,365 | 4,727,510 | SUVRETTA CAPITAL MANAGEMENT, LLC | 04 Mar 2025 | |||
| ORBIMED ADVISORS LLC | 8.9% | $6,415,640 | 4,166,000 | OrbiMed Advisors LLC | 31 Mar 2025 | |||
| ABG Management Ltd. | 6.3% | $4,488,492 | 2,914,605 | Fan Yu | 04 Mar 2025 | |||
| Coastlands Capital LP | 6% | $5,074,587 | 2,819,215 | Coastlands Capital LP | 19 Aug 2025 | |||
| BML Investment Partners, L.P. | 5% | -49% | $3,749,900 | -$331,178 | 2,435,000 | 0% | Leonard Braden Michael | 05 Mar 2025 |
| QVT Financial LP | 9.4% | $3,563,101 | 2,313,702 | QVT Financial LP | 31 Dec 2024 | |||
| Desai Neil | 4.9% | -48% | $3,500,329 | +$14,438 | 2,272,941 | +0.41% | Neil Desai | 04 Mar 2025 |
| ACUTA CAPITAL PARTNERS, LLC | 7.8% | $2,958,797 | 1,921,297 | Anupam Dalal | 19 Dec 2024 | |||
| EcoR1 Capital, LLC | 1.4% | $531,690 | 345,253 | EcoR1 Capital, LLC | 31 Dec 2024 | |||
| Point72 Asset Management, L.P. | 0% | -100% | $7,834 | -$2,256,445 | 5,087 | -100% | Point72 Asset Management, L.P. | 31 Mar 2025 |
| Satter Muneer A | 0% | $1,015 | 659 | Satter Muneer A | 31 Dec 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| QVT Financial LP | 9.8% | 4,615,709 | 0% | 0.92% | $8,331,355 |
| ORBIMED ADVISORS LLC | 8.8% | 4,166,000 | 0% | 0.19% | $7,915,400 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7.8% | 3,700,000 | 0% | 0.21% | $7,030,000 |
| ACUTA CAPITAL PARTNERS, LLC | 7.2% | 3,410,402 | 0% | 6.7% | $6,479,764 |
| Avoro Capital Advisors LLC | 6% | 2,849,402 | 0% | 0.07% | $5,413,864 |
| Siren, L.L.C. | 4.4% | 2,082,000 | 0% | 0.15% | $3,955,800 |
| Yu Fan | 4.4% | 2,070,000 | 0% | 5.1% | $3,933,000 |
| VANGUARD GROUP INC | 2.8% | 1,342,907 | +2.1% | 0% | $2,551,523 |
| ACORN CAPITAL ADVISORS, LLC | 2.4% | 1,139,363 | 0% | 1.1% | $2,164,790 |
| Ally Bridge Group (NY) LLC | 1.7% | 817,939 | 0% | 1.3% | $1,554,084 |
| RENAISSANCE TECHNOLOGIES LLC | 0.97% | 457,422 | -0.17% | 0% | $869,102 |
| STEMPOINT CAPITAL LP | 0.9% | 424,082 | 0.16% | $805,756 | |
| GEODE CAPITAL MANAGEMENT, LLC | 0.81% | 381,754 | +2.5% | 0% | $725,695 |
| Peapod Lane Capital LLC | 0.64% | 303,585 | +25% | 0.52% | $577,064 |
| BlackRock, Inc. | 0.63% | 296,158 | -0.72% | 0% | $562,701 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0.46% | 215,284 | -32% | 0.01% | $409,040 |
| CITADEL ADVISORS LLC | 0.3% | 140,220 | +391% | 0% | $266,418 |
| Squarepoint Ops LLC | 0.18% | 83,660 | +36% | 0% | $158,954 |
| NORTHERN TRUST CORP | 0.15% | 72,164 | -22% | 0% | $137,111 |
| STATE STREET CORP | 0.15% | 68,737 | 0% | 0% | $130,600 |
| DIMENSIONAL FUND ADVISORS LP | 0.09% | 44,115 | -38% | 0% | $83,818 |
| Stonepine Capital Management, LLC | 0.07% | 35,253 | 0.05% | $66,981 | |
| ABG Innovation Capital Partners III GP Ltd | 0.06% | 26,666 | 0% | 100% | $50,665 |
| ACADIAN ASSET MANAGEMENT LLC | 0.06% | 26,206 | 0% | $49,000 | |
| JANE STREET GROUP, LLC | 0.05% | 25,215 | -76% | 0% | $47,908 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 28,831,370 | $54,340,996 | -$1,110,993 | $1.90 | 39 |
| 2025 Q2 | 29,433,136 | $54,608,497 | -$4,256,988 | $1.87 | 38 |
| 2025 Q1 | 31,810,129 | $56,220,211 | +$29,068,777 | $1.78 | 48 |
| 2024 Q4 | 14,964,504 | $47,212,864 | +$5,023,549 | $3.16 | 51 |
| 2024 Q3 | 11,974,976 | $24,667,146 | +$1,827,419 | $2.06 | 51 |
| 2024 Q2 | 11,470,837 | $16,746,144 | -$3,322,352 | $1.46 | 63 |
| 2024 Q1 | 13,209,848 | $30,910,957 | +$1,200,705 | $2.34 | 59 |
| 2023 Q4 | 12,774,914 | $25,805,815 | -$10,140,228 | $2.02 | 62 |
| 2023 Q3 | 14,216,215 | $68,812,109 | +$1,540,803 | $4.84 | 69 |
| 2023 Q2 | 13,790,216 | $94,355,740 | -$714,623 | $6.84 | 65 |
| 2023 Q1 | 13,831,279 | $100,129,503 | -$16,765,639 | $7.24 | 68 |
| 2022 Q4 | 15,301,334 | $192,201,785 | +$3,741,246 | $12.83 | 73 |
| 2022 Q3 | 14,991,886 | $211,814,933 | +$32,802,356 | $14.13 | 65 |
| 2022 Q2 | 12,823,915 | $158,008,315 | +$4,841,924 | $12.32 | 65 |
| 2022 Q1 | 12,574,186 | $213,400,829 | -$7,136,755 | $16.97 | 51 |
| 2021 Q4 | 12,184,052 | $294,238,682 | +$23,944,526 | $24.15 | 44 |
| 2021 Q3 | 11,096,563 | $324,110,000 | +$324,110,000 | $29.37 | 30 |