Comparable stake leader
James E. Flynn
Top holders, 13D/G large-stake signals, insider positions, and transaction flow tied to CIK 0001861560.
Comparable stake leader
James E. Flynn
Disclosed value leader
James E. Flynn
Comparable rows
50/50
Latest evidence
16 Jun 2026
Ownership snapshot
Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.
Quick read
50 of 50 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.
Ownership % is shown only when SEC disclosures are safely comparable across share classes.
| Holder | Evidence | Ownership % | Position | 12M Net Δ | As of |
|---|---|---|---|---|---|
| James E. Flynn |
13D/G
3/4/5
Deerfield Management Company, L.P. · Director, Director by Deputization, 10%+ Owner
|
24%
|
$2,238,152,303
22,852,280 shares
|
-$71,496,004 | 31 Dec 2025 |
| FMR LLC |
13D/G
13F
Company
|
13%
|
$959,541,420
9,252,159 shares
|
$0 | 31 Mar 2026 |
| VANGUARD GROUP INC |
13D/G
The Vanguard Group
|
6.8%
|
$330,650,007
4,499,864 shares
|
$0 | 31 Dec 2024 |
| BlackRock, Inc. |
13F
13D/G
Company
|
5%
from 13D/G
|
$494,299,250
4,824,785 shares
|
— | 31 Mar 2026 |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
3/4/5
13F
Director, Director by Deputization, 10%+ Owner · Company
|
23%
|
$1,767,456,539
17,251,894 shares
|
— | 16 Jun 2026 |
| Paradigm Biocapital Advisors LP |
13F
Company
|
7.3%
|
$545,488,161
5,324,433 shares
|
— | 31 Mar 2026 |
| JPMORGAN CHASE & CO |
13F
Company
|
4.2%
|
$298,705,153
3,088,349 shares
|
— | 31 Mar 2026 |
| RA CAPITAL MANAGEMENT, L.P. |
13F
Company
|
3.5%
|
$259,623,155
2,534,145 shares
|
— | 31 Mar 2026 |
Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
Forms 3/4/5 flow
Net insider flow leans to selling over the last 12 months. Net value: -$151,228,167.
| Window (months) | Buy shares | Sell shares | Buy value | Sell value | Net value |
|---|---|---|---|---|---|
| 0-3 | 0 | 168,953 | $0 | $17,410,636 | -$17,410,636 |
| 3-6 | 0 | 205,960 | $0 | $20,519,677 | -$20,519,677 |
| 6-9 | 0 | 1,031,845 | $0 | $98,884,270 | -$98,884,270 |
| 9-12 | 0 | 177,458 | $0 | $14,413,583 | -$14,413,583 |
Reporting owners
Showing 1-20 of 24 reporting-owner rows connected to Nuvalent, Inc.. Open a relationship link for the CIK-to-CIK filing trail.
| Name | Relationship | Holdings Value | Past Year Net Change | Change % | Valuation | Report Date |
|---|---|---|---|---|---|---|
| James E. Flynn | Director, Director by Deputization, 10%+ Owner | $1,822,485,539 | -$70,874,975 | -3.7% | Mixed | 16 Jun 2026 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Director, Director by Deputization, 10%+ Owner | $1,767,456,539 | Median | 16 Jun 2026 | ||
| Matthew Shair | Director | $174,338,383 | -$6,835,738 | -3.8% | Filing P/S | 24 Nov 2025 |
| Andrew A. F. Hack | Director | $127,579,408 | Mixed | 11 Dec 2024 | ||
| Wellington Biomedical Innovation Master Investors (Cayman) I L.P. | 10%+ Owner | $68,348,670 | Mixed | 02 Aug 2021 | ||
| DEERFIELD PARTNERS, L.P. | Director, Director by Deputization, 10%+ Owner | $49,491,000 | Mixed | 03 Nov 2022 | ||
| James Richard Porter | President and CEO, Director | $29,118,904 | -$23,297,579 | -44% | Filing P/S | 08 Jun 2026 |
| Alexandra Balcom | Chief Financial Officer | $8,881,746 | -$18,884,287 | -68% | Filing P/S | 01 Jun 2026 |
| Christopher Durant Turner | Chief Medical Officer | $7,305,924 | -$721,320 | -9% | Mixed | 05 Jan 2026 |
| Darlene Noci | Chief Development Officer | $7,178,030 | -$8,861,694 | -55% | Filing P/S | 29 Jun 2026 |
| Henry E. Pelish | Chief Scientific Officer | $6,888,420 | -$7,760,672 | -53% | Filing P/S | 09 Apr 2026 |
| Deborah Ann Miller | Chief Legal Officer | $6,517,996 | -$13,991,901 | -68% | Filing P/S | 28 May 2026 |
| Benjamin Lane | Chief Technical Operations Officer | $5,066,517 | Mixed | 01 Apr 2026 | ||
| Grant C. Bogle | Director | $951,862 | Median | 16 Jun 2026 | ||
| Michael L. Meyers | Director | $880,045 | Median | 16 Jun 2026 | ||
| Cameron Wheeler | Director | $880,045 | Median | 16 Jun 2026 | ||
| Anna Protopapas | Director | $880,045 | Median | 16 Jun 2026 | ||
| Sapna Srivastava | Director | $880,045 | Median | 16 Jun 2026 | ||
| Christy J. Oliger | Director | $759,666 | Median | 16 Jun 2026 | ||
| Ron Squarer | Director | $643,488 | Median | 16 Jun 2026 |
Showing up to 300 recent insider transactions from the last 12 months.
| Insider | Symbol | Class | Transaction | % | SEC-reported value | SEC-reported price | Shares | Shares owned | Date | Ownership |
|---|---|---|---|---|---|---|---|---|---|---|
| Darlene Noci | NUVL | Class A Common Stock | Sale | -8.65% | $679,305 | $123.51 | -5,500 | 58,117 | 29 Jun 2026 | Direct |
| Darlene Noci | NUVL | Class A Common Stock | Options Exercise | 9.46% | 5,500 | 63,617 | 29 Jun 2026 | Direct | ||
| Darlene Noci | NUVL | Stock Option (Right to Buy) | Options Exercise | -6.33% | -5,500 | 81,329 | 29 Jun 2026 | Direct | ||
| Flynn James E | NUVL | Class A Common Stock | Award | 3,444 | 3,444 | 16 Jun 2026 | Through Deerfield Management Company, L.P. | |||
| James E. Flynn | NUVL | Class A Common Stock | Award | 3,444 | 3,444 | 16 Jun 2026 | Through Deerfield Management Company, L.P. | |||
| Cameron Wheeler | NUVL | Class A Common Stock | Award | 66.9% | 3,444 | 8,590 | 16 Jun 2026 | Direct | ||
| Sapna Srivastava | NUVL | Class A Common Stock | Award | 66.9% | 3,444 | 8,590 | 16 Jun 2026 | Direct | ||
| Ron Squarer | NUVL | Class A Common Stock | Award | 121.4% | 3,444 | 6,281 | 16 Jun 2026 | Direct | ||
| Anna Protopapas | NUVL | Class A Common Stock | Award | 66.9% | 3,444 | 8,590 | 16 Jun 2026 | Direct | ||
| Christy J. Oliger | NUVL | Class A Common Stock | Award | 86.7% | 3,444 | 7,415 | 16 Jun 2026 | Direct | ||
| Michael L. Meyers | NUVL | Class A Common Stock | Award | 66.9% | 3,444 | 8,590 | 16 Jun 2026 | Direct | ||
| Grant C. Bogle | NUVL | Class A Common Stock | Award | 58.9% | 3,444 | 9,291 | 16 Jun 2026 | Direct | ||
| Darlene Noci | NUVL | Class A Common Stock | Sale | -25.6% | $2,456,200 | $122.81 | -20,000 | 58,117 | 09 Jun 2026 | Direct |
| Darlene Noci | NUVL | Class A Common Stock | Options Exercise | 34.4% | 20,000 | 78,117 | 09 Jun 2026 | Direct | ||
| Darlene Noci | NUVL | Stock Option (Right to Buy) | Options Exercise | -98.9% | -20,000 | 216 | 09 Jun 2026 | Direct | ||
| James Richard Porter | NUVL | Class A Common Stock | Sale | -8.45% | $2,656,004 | $88.53 | -30,000 | 324,879 | 08 Jun 2026 | Direct |
| James Richard Porter | NUVL | Class A Common Stock | Options Exercise | 9.23% | 30,000 | 354,879 | 08 Jun 2026 | Direct | ||
| James Richard Porter | NUVL | Stock Option (Right to Buy) | Options Exercise | -16.8% | -30,000 | 148,686 | 08 Jun 2026 | Direct | ||
| Alexandra Balcom | NUVL | Class A Common Stock | Sale | -11.8% | $1,128,080 | $98.69 | -11,430 | 85,533 | 01 Jun 2026 | Direct |
| Alexandra Balcom | NUVL | Class A Common Stock | Options Exercise | 13.4% | 11,430 | 96,963 | 01 Jun 2026 | Direct | ||
| Alexandra Balcom | NUVL | Stock Option (Right to Buy) | Options Exercise | -46% | -11,430 | 13,400 | 01 Jun 2026 | Direct | ||
| Darlene Noci | NUVL | Class A Common Stock | Sale | -8.65% | $592,923 | $107.80 | -5,500 | 58,117 | 28 May 2026 | Direct |
| Darlene Noci | NUVL | Class A Common Stock | Options Exercise | 9.46% | 5,500 | 63,617 | 28 May 2026 | Direct | ||
| Darlene Noci | NUVL | Stock Option (Right to Buy) | Options Exercise | -5.96% | -5,500 | 86,829 | 28 May 2026 | Direct | ||
| Deborah Ann Miller | NUVL | Class A Common Stock | Sale | -8.44% | $593,101 | $107.84 | -5,500 | 59,634 | 28 May 2026 | Direct |
| Deborah Ann Miller | NUVL | Class A Common Stock | Options Exercise | 9.22% | 5,500 | 65,134 | 28 May 2026 | Direct | ||
| Deborah Ann Miller | NUVL | Stock Option (Right to Buy) | Options Exercise | -7.04% | -5,500 | 72,608 | 28 May 2026 | Direct | ||
| Deborah Ann Miller | NUVL | Class A Common Stock | Sale | -8.44% | $593,101 | $107.84 | -5,500 | 59,634 | 28 May 2026 | Direct |
| Deborah Ann Miller | NUVL | Class A Common Stock | Options Exercise | 9.22% | 5,500 | 65,134 | 28 May 2026 | Direct | ||
| Deborah Ann Miller | NUVL | Stock Option (Right to Buy) | Options Exercise | -7.04% | -5,500 | 72,608 | 28 May 2026 | Direct | ||
| James Richard Porter | NUVL | Class A Common Stock | Sale | -8.45% | $3,050,712 | $101.69 | -30,000 | 324,879 | 04 May 2026 | Direct |
| James Richard Porter | NUVL | Class A Common Stock | Options Exercise | 9.23% | 30,000 | 354,879 | 04 May 2026 | Direct | ||
| James Richard Porter | NUVL | Stock Option (Right to Buy) | Options Exercise | -14.4% | -30,000 | 178,686 | 04 May 2026 | Direct | ||
| Alexandra Balcom | NUVL | Class A Common Stock | Sale | -11.8% | $1,131,600 | $99.00 | -11,430 | 85,533 | 01 May 2026 | Direct |
| Alexandra Balcom | NUVL | Class A Common Stock | Options Exercise | 13.4% | 11,430 | 96,963 | 01 May 2026 | Direct | ||
| Alexandra Balcom | NUVL | Stock Option (Right to Buy) | Options Exercise | -31.5% | -11,430 | 24,830 | 01 May 2026 | Direct | ||
| Deborah Ann Miller | NUVL | Class A Common Stock | Sale | -8.44% | $545,691 | $99.22 | -5,500 | 59,634 | 30 Apr 2026 | Direct |
| Deborah Ann Miller | NUVL | Class A Common Stock | Options Exercise | 9.22% | 5,500 | 65,134 | 30 Apr 2026 | Direct | ||
| Deborah Ann Miller | NUVL | Stock Option (Right to Buy) | Options Exercise | -6.58% | -5,500 | 78,108 | 30 Apr 2026 | Direct | ||
| Darlene Noci | NUVL | Class A Common Stock | Sale | -8.65% | $547,524 | $99.55 | -5,500 | 58,117 | 29 Apr 2026 | Direct |
| Darlene Noci | NUVL | Class A Common Stock | Options Exercise | 9.46% | 5,500 | 63,617 | 29 Apr 2026 | Direct | ||
| Darlene Noci | NUVL | Stock Option (Right to Buy) | Options Exercise | -5.62% | -5,500 | 92,329 | 29 Apr 2026 | Direct | ||
| Henry E. Pelish | NUVL | Class A Common Stock | Sale | -4.5% | $323,164 | $104.48 | -3,093 | 65,604 | 09 Apr 2026 | Direct |
| Henry E. Pelish | NUVL | Class A Common Stock | Options Exercise | 4.71% | 3,093 | 68,697 | 09 Apr 2026 | Direct | ||
| Henry E. Pelish | NUVL | Stock Option (Right to Buy) | Options Exercise | -27.1% | -3,093 | 8,309 | 09 Apr 2026 | Direct | ||
| James Richard Porter | NUVL | Class A Common Stock | Sale | -8.45% | $3,113,231 | $103.77 | -30,000 | 324,879 | 06 Apr 2026 | Direct |
| James Richard Porter | NUVL | Class A Common Stock | Options Exercise | 9.23% | 30,000 | 354,879 | 06 Apr 2026 | Direct | ||
| James Richard Porter | NUVL | Stock Option (Right to Buy) | Options Exercise | -18.6% | -30,000 | 131,494 | 06 Apr 2026 | Direct | ||
| Alexandra Balcom | NUVL | Class A Common Stock | Sale | -11.8% | $1,202,527 | $105.21 | -11,430 | 85,533 | 01 Apr 2026 | Direct |
| Alexandra Balcom | NUVL | Class A Common Stock | Options Exercise | 13.4% | 11,430 | 96,963 | 01 Apr 2026 | Direct |