| Cormorant Asset Management, LP |
|
Ordinary Shares |
Purchase |
1.09% |
$6,944,924 |
$9.24 |
751,233 |
69,465,823 |
18 Sep 2023 |
See Footnotes |
| Cormorant Asset Management, LP |
|
Ordinary Shares |
Purchase |
2.08% |
$12,680,677 |
$9.05 |
1,401,505 |
68,714,590 |
15 Sep 2023 |
See Footnotes |
| Margaret Dalesandro |
|
Ordinary Shares |
Award |
|
|
|
195,833 |
125,000 |
01 Sep 2023 |
Direct |
| Andrew Aromando |
|
Stock Option (right to buy) |
Award |
|
|
|
389,000 |
389,000 |
05 Jul 2023 |
Direct |
| Sonja Nelson |
|
Stock Option (right to buy) |
Award |
|
|
|
389,000 |
389,000 |
05 Jul 2023 |
Direct |
| Daniel J. O'Connor |
|
Stock Option (right to buy) |
Award |
|
|
|
1,216,500 |
1,216,500 |
05 Jul 2023 |
Direct |
| Darwin Global Management, Ltd. |
|
American Depository Shares ("ADSs") |
Purchase |
47.6% |
|
|
5,384,063 |
16,688,636 |
27 Jun 2023 |
See footnotes |
| Janet Loesberg |
|
Ordinary Shares |
Award |
|
|
|
85,000 |
85,000 |
07 Jun 2023 |
Direct |
| Xiaowei Chang |
|
Cash-Settled RSU's |
Award |
-71.2% |
|
|
-210,000 |
85,000 |
07 Jun 2023 |
Direct |
| Kate Hermans |
|
Ordinary Shares |
Award |
|
|
|
85,000 |
85,000 |
07 Jun 2023 |
Direct |
| Stephen C. Glover |
|
Ordinary Shares |
Award |
|
|
|
85,000 |
85,000 |
07 Jun 2023 |
Direct |
| Stephen C. Glover |
|
Stock Option (right to buy) |
Award |
|
|
|
40,000 |
40,000 |
07 Jun 2023 |
Direct |
| Paul Maier V |
|
Ordinary Shares |
Award |
|
|
|
85,000 |
85,000 |
07 Jun 2023 |
Direct |
| Stephen C. Glover |
|
Stock Option (right to buy) |
Award |
|
|
|
17,500 |
17,500 |
18 May 2023 |
Direct |
| Stephen C. Glover |
|
Stock Option (right to buy) |
Award |
|
|
|
210,000 |
210,000 |
18 May 2023 |
Direct |
| Andrew Aromando |
|
Stock Option (right to buy) |
Award |
|
|
|
2,600,000 |
2,600,000 |
28 Apr 2023 |
Direct |
| Sonja Nelson |
|
Ordinary Shares |
Award |
|
|
|
1,000,000 |
1,000,000 |
26 Apr 2023 |
Direct |
| Daniel J. O'Connor |
|
Ordinary Shares |
Award |
|
|
|
2,750,000 |
2,750,000 |
26 Apr 2023 |
Direct |
| Cormorant Asset Management, LP |
|
Ordinary Shares |
Purchase |
1.33% |
$10,285,220 |
$11.60 |
886,634 |
67,313,085 |
20 Apr 2023 |
See Footnotes |
| Cormorant Asset Management, LP |
|
Ordinary Shares |
Purchase |
1.45% |
$10,612,357 |
$11.15 |
951,909 |
66,426,451 |
19 Apr 2023 |
See Footnotes |
| Cormorant Asset Management, LP |
|
Ordinary Shares |
Purchase |
5.44% |
$38,053,112 |
$11.27 |
3,376,646 |
65,474,542 |
18 Apr 2023 |
See Footnotes |
| Cormorant Asset Management, LP |
|
Ordinary Shares |
Purchase |
0.91% |
$5,999,461 |
$10.67 |
562,121 |
62,097,896 |
17 Apr 2023 |
See Footnotes |
| Cormorant Asset Management, LP |
|
Ordinary Shares |
Purchase |
1.39% |
$8,384,307 |
$9.96 |
841,967 |
61,535,775 |
14 Apr 2023 |
See Footnotes |
| Cormorant Asset Management, LP |
|
Ordinary Shares |
Purchase |
2.01% |
$10,935,520 |
$9.16 |
1,193,808 |
60,693,808 |
13 Apr 2023 |
See Footnotes |
| Cormorant Asset Management, LP |
|
Ordinary Shares |
Purchase |
0.94% |
$5,074,250 |
$10.15 |
500,000 |
53,500,000 |
16 Mar 2023 |
See Footnotes |
| Cormorant Asset Management, LP |
|
Ordinary Shares |
Purchase |
0.47% |
$2,648,875 |
$10.60 |
250,000 |
53,000,000 |
15 Mar 2023 |
See Footnotes |
| Cormorant Asset Management, LP |
|
Ordinary Shares |
Purchase |
0.48% |
$2,488,275 |
$9.95 |
250,000 |
52,750,000 |
14 Mar 2023 |
See Footnotes |
| Darwin Global Management, Ltd. |
|
ADSs |
Purchase |
47% |
|
|
3,615,000 |
11,304,573 |
06 Mar 2023 |
See footnotes |
| Darwin Global Management, Ltd. |
|
ADSs |
Purchase |
0.52% |
|
|
39,957 |
7,689,573 |
28 Feb 2023 |
See footnotes |
| Darwin Global Management, Ltd. |
|
American Depository Shares ("ADSs") |
Purchase |
0.86% |
|
|
65,127 |
7,649,616 |
27 Feb 2023 |
See footnotes |
| Katrin Rupalla |
|
Stock Option (right to buy) |
Disposed to Issuer |
-100% |
|
|
-305,000 |
0 |
27 Jan 2023 |
Direct |
| Katrin Rupalla |
|
Stock Option (right to buy) |
Award |
|
|
|
305,000 |
200,000 |
27 Jan 2023 |
Direct |
| Janet Loesberg |
|
Stock Option (right to buy) |
Award |
|
|
|
315,000 |
210,000 |
27 Jan 2023 |
Direct |
| Janet Loesberg |
|
Stock Option (right to buy) |
Disposed to Issuer |
-100% |
|
|
-315,000 |
0 |
27 Jan 2023 |
Direct |
| Kate Hermans |
|
Stock Option (right to buy) |
Disposed to Issuer |
-100% |
|
|
-525,000 |
0 |
27 Jan 2023 |
Direct |
| Kate Hermans |
|
Stock Option (right to buy) |
Award |
|
|
|
525,000 |
210,000 |
27 Jan 2023 |
Direct |
| Sonja Nelson |
|
Employee Stock Option (right to buy) |
Disposed to Issuer |
-100% |
|
|
-3,849,596 |
0 |
27 Jan 2023 |
Direct |
| Sonja Nelson |
|
Employee Stock Option (right to buy) |
Award |
|
|
|
3,849,596 |
2,574,596 |
27 Jan 2023 |
Direct |
| Paul Maier V |
|
Stock Option (right to buy) |
Disposed to Issuer |
-100% |
|
|
-315,000 |
0 |
27 Jan 2023 |
Direct |
| Paul Maier V |
|
Stock Option (right to buy) |
Award |
|
|
|
315,000 |
210,000 |
27 Jan 2023 |
Direct |