Insider Transactions Reported by 18 Insiders of CATALYST PHARMACEUTICALS, INC.

Symbol: CPRX on Nasdaq
Location: Coral Gables, FL

Quick Takeaways

CPRX - CATALYST PHARMACEUTICALS, INC. has 18 insiders with reported activity on this page.
Net insider value flow over the last year: -$14,253,913.
Recent transaction rows are available for direct filing-level review.

What Changed

Buy value: $2,648,200; sell value: $16,902,113.
Net share flow: -619,623.

Why This Matters

This page gives a plain-language issuer insider context before you inspect transaction-level evidence.
Use the filing links below to verify timestamps, codes, and ownership impacts directly from SEC forms.

Source Evidence

Filed on Form 4

Issuer insider activity is sourced from SEC Forms 3, 4, and 5.

See Original Filing

Insider trading overview

Last 12 months

Net insider flow leans to selling over the last 12 months. Net value: -$14,253,913.

Buys

$2,648,200

Shares: 110,000

Insiders: 2

Sells

$16,902,113

Shares: 729,623

Insiders: 9

Net

-$14,253,913

Shares: -619,623

Insiders: -7

Window (months)	Buy shares	Sell shares	Buy $	Sell $	Net $
0-3	0	0	$0	$0	$0
3-6	40,000	37,729	$908,000	$878,165	+$29,835
6-9	0	243,970	$0	$4,927,241	-$4,927,241
9-12	70,000	447,924	$1,740,200	$11,096,707	-$9,356,507

CATALYST PHARMACEUTICALS, INC. executives and other stock owners filed with the SEC include:

Name	Relationship	Holdings Value	Past Year Net Change	Change %	Valuation	Report Date
Patrick J. McEnany	Director, Chairman of Board of Directors	$105,777,977	-$5,217,338	-4.7%	Mixed	29 Dec 2025
Steve Miller	Chief Op. & Scientific Officer	$29,217,712	-$2,332,200	-7.4%	Mixed	29 Dec 2025
Donald A. Denkhaus	Director	$12,120,589			Mixed	29 Dec 2025
Richard J. Daly	President and CEO, Director	$11,337,222	+$1,266,559	+13%	Mixed	05 Jan 2026
David S. Tierney	Director	$9,508,911	-$525,200	-5.2%	Mixed	29 Dec 2025
Brian Elsbernd	Chief Compliance/Legal Officer	$8,121,002	-$688,200	-7.8%	Mixed	29 Dec 2025
Gary Ingenito	Chief Med. & Reg. Officer	$3,901,700	-$5,775,720	-60%	Mixed	13 May 2025
Preethi Sundaram	Chief Strategy Officer	$2,812,514	-$103,649	-3.6%	Mixed	29 Dec 2025
Jeffrey del Carmen	Chief Commercial Officer	$2,423,667	-$256,244	-9.6%	Mixed	29 Dec 2025
Michael W. Kalb	Executive Vice President & CFO	$2,226,495			Mixed	05 Jan 2026
Charles B. O'Keeffe	Director	$2,107,267			Mixed	14 Feb 2025
Alicia Grande	VP, Treasurer and CFO	$1,404,569			Mixed	27 Dec 2023
Tamar Thompson	Director	$475,599			Mixed	08 Dec 2025
Molly Harper	Director	$372,235	-$621,920	-63%	Mixed	29 Dec 2025
Philip H. Coelho	Director	$231,522			Mixed	04 May 2023
Gregg Russo	Chief HR Officer	$11,700			Mixed	17 Feb 2026
William T. Andrews	Chief Medical Officer	$0			Mixed	20 Nov 2025
Daniel J. Curran	Director	$0			Mixed	20 Nov 2025

Top shareholders of CATALYST PHARMACEUTICALS, INC. (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.

Methodology: rows are grouped by holder and ranked by the holder's primary source value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

Holder	Source	Role / Reporting	Ownership %	Shares	Holdings Value	12M Net Δ	As of	Details
BlackRock, Inc.	13F 13D/G	Company	14% from 13D/G	18,626,781	$434,749,068	—	31 Dec 2025	13F 13D/G
VANGUARD GROUP INC	13F	Company	6.8%	8,432,247	$196,808,646	—	31 Dec 2025	13F
STATE STREET CORP	13F 13D/G	Company · STATE STREET CORPORATION	5.2% from 13D/G	6,907,622	$161,223,897	—	31 Dec 2025	13F 13D/G
DEERFIELD MANAGEMENT COMPANY, L.P.	13F	Company	4%	4,911,161	$114,626,498	—	31 Dec 2025	13F
Patrick J. McEnany	3/4/5	Director, Chairman of Board of Directors	— mixed-class rows	7,896,558 mixed-class rows	$105,777,977	-$5,217,338	29 Dec 2025	3/4/5
Fundsmith LLP	13F	Company	2.7%	3,363,807	$78,511,255	—	31 Dec 2025	13F
James E. Flynn	13D/G	Deerfield Mgmt, L.P.	2.6%	3,133,011	$74,033,050	$0	31 Dec 2024	13D/G
AMERICAN CENTURY COMPANIES INC	13F	Company	2.5%	3,025,271	$70,609,825	—	31 Dec 2025	13F
DIMENSIONAL FUND ADVISORS LP	13F	Company	2.4%	2,996,297	$69,932,608	—	31 Dec 2025	13F
MORGAN STANLEY	13F	Company	2.4%	2,933,399	$68,465,565	—	31 Dec 2025	13F
GEODE CAPITAL MANAGEMENT, LLC	13F	Company	2.4%	2,900,337	$67,704,365	—	31 Dec 2025	13F
RENAISSANCE TECHNOLOGIES LLC	13F	Company	2.2%	2,650,077	$61,852,797	—	31 Dec 2025	13F
BANK OF AMERICA CORP /DE/	13F	Company	1.8%	2,199,842	$51,344,312	—	31 Dec 2025	13F
ROYCE & ASSOCIATES LP	13F	Company	1.6%	1,910,767	$44,597,302	—	31 Dec 2025	13F
JANUS HENDERSON GROUP PLC	13F	Company	1.4%	1,719,767	$40,123,723	—	31 Dec 2025	13F
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	13F	Company	1.3%	1,617,208	$37,745,635	—	31 Dec 2025	13F
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	13F	Company	1.1%	1,356,499	$31,660,687	—	31 Dec 2025	13F
Invesco Ltd.	13F	Company	1.1%	1,293,478	$30,189,776	—	31 Dec 2025	13F
Steve Miller	3/4/5	Chief Op. & Scientific Officer	— mixed-class rows	4,023,415 mixed-class rows	$29,217,712	-$2,332,200	29 Dec 2025	3/4/5
Boston Partners	13F	Company	1%	1,231,372	$28,539,969	—	31 Dec 2025	13F
NORTHERN TRUST CORP	13F	Company	0.98%	1,211,973	$28,287,449	—	31 Dec 2025	13F
KENNEDY CAPITAL MANAGEMENT LLC	13F	Company	0.98%	1,209,692	$28,234,211	—	31 Dec 2025	13F
MILLENNIUM MANAGEMENT LLC	13F	Company	0.81%	993,647	$23,191,721	—	31 Dec 2025	13F
GOLDMAN SACHS GROUP INC	13F	Company	0.8%	979,543	$22,862,534	—	31 Dec 2025	13F
VICTORY CAPITAL MANAGEMENT INC	13F	Company	0.72%	884,605	$20,646,681	—	31 Dec 2025	13F
RAYMOND JAMES FINANCIAL INC	13F	Company	0.68%	841,914	$19,624,682	—	31 Dec 2025	13F
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	13F	Company	0.63%	778,591	$18,172,000	—	31 Dec 2025	13F
Legal & General Group Plc	13F	Company	0.63%	776,172	$18,115,855	—	31 Dec 2025	13F
PRICE T ROWE ASSOCIATES INC /MD/	13F	Company	0.61%	748,781	$17,477,000	—	31 Dec 2025	13F
SYSTEMATIC FINANCIAL MANAGEMENT LP	13F	Company	0.59%	723,242	$16,880,497	—	31 Dec 2025	13F
Bank of New York Mellon Corp	13F	Company	0.57%	700,661	$16,353,427	—	31 Dec 2025	13F
PRINCIPAL FINANCIAL GROUP INC	13F	Company	0.56%	683,678	$15,957,045	—	31 Dec 2025	13F
FEDERATED HERMES, INC.	13F	Company	0.54%	663,754	$15,492,019	—	31 Dec 2025	13F
UBS Group AG	13F	Company	0.53%	648,987	$15,147,357	—	31 Dec 2025	13F
GLENMEDE TRUST CO NA	13F	Company	0.5%	618,218	$14,429,207	—	31 Dec 2025	13F
Swedbank AB	13F	Company	0.5%	616,132	$14,380,521	—	31 Dec 2025	13F
MetLife Investment Management, LLC	13F	Company	0.48%	594,073	$13,865,664	—	31 Dec 2025	13F
OBERWEIS ASSET MANAGEMENT INC/	13F	Company	0.48%	586,970	$13,699,880	—	31 Dec 2025	13F
VOYA INVESTMENT MANAGEMENT LLC	13F	Company	0.46%	567,441	$13,244,073	—	31 Dec 2025	13F
LSV ASSET MANAGEMENT	13F	Company	0.44%	539,900	$12,601,000	—	31 Dec 2025	13F
Donald A. Denkhaus	3/4/5	Director	— mixed-class rows	853,325 mixed-class rows	$12,120,589	—	29 Dec 2025	3/4/5
PUBLIC SECTOR PENSION INVESTMENT BOARD	13F	Company	0.4%	492,939	$11,505,196	—	31 Dec 2025	13F
Qube Research & Technologies Ltd	13F	Company	0.4%	487,135	$11,369,731	—	31 Dec 2025	13F
Richard J. Daly	3/4/5	President and CEO, Director	— mixed-class rows	5,436,500 mixed-class rows	$11,337,222	+$1,266,559	05 Jan 2026	3/4/5
GABLES CAPITAL MANAGEMENT INC.	13F	Company	0.34%	424,621	$9,910,654	—	31 Dec 2025	13F
Nuveen, LLC	13F	Company	0.34%	418,521	$9,768,280	—	31 Dec 2025	13F
David S. Tierney	3/4/5	Director	— mixed-class rows	737,866 mixed-class rows	$9,508,911	-$525,200	29 Dec 2025	3/4/5
Pacer Advisors, Inc.	13F	Company	0.32%	393,733	$9,189,728	—	31 Dec 2025	13F
JUPITER ASSET MANAGEMENT LTD	13F	Company	0.32%	390,368	$9,111,189	—	31 Dec 2025	13F
JW Asset Management, LLC	13F	Company	0.32%	388,392	$9,065,069	—	31 Dec 2025	13F

Recent Insider Transactions by Companies or Individuals for CATALYST PHARMACEUTICALS, INC.

Showing up to 300 most recent insider transactions from the last 12 months.

Insider	Symbol	Class	Transaction	%	Value $	* Price $	Shares	Shares Owned	Date	Ownership
Gregg Russo	CPRX	Common Stock, par value $0.001 per share	Tax liability	-30.7%			-211	476	17 Feb 2026	Direct
Gregg Russo	CPRX	Common Stock, par value $0.001 per share	Options Exercise				687	687	17 Feb 2026	Direct
Gregg Russo	CPRX	Restricted Stock Units	Options Exercise	-0.95%			-687	71,786	17 Feb 2026	Direct
Michael W. Kalb	CPRX	Common Stock, par value $0.001 per share	Tax liability	-13.2%			-2,080	13,665	05 Jan 2026	Direct
Michael W. Kalb	CPRX	Common Stock, par value $0.001 per share	Options Exercise	83%			7,139	15,745	05 Jan 2026	Direct
Michael W. Kalb	CPRX	Restricted Stock Units	Options Exercise	-1.12%			-7,139	632,903	05 Jan 2026	Direct
Richard J. Daly	CPRX	Common Stock, par value $0.001 per share	Tax liability	-3.75%			-10,577	271,266	05 Jan 2026	Direct
Richard J. Daly	CPRX	Common Stock, par value $0.001 per share	Options Exercise	17.6%			42,105	281,843	05 Jan 2026	Direct
Richard J. Daly	CPRX	Restricted Stock Units	Options Exercise	-1.58%			-42,105	2,618,539	05 Jan 2026	Direct
Donald A. Denkhaus	CPRX	Common Stock, par value $0.001 per share	Options Exercise	0.27%			1,334	498,773	29 Dec 2025	Direct
Donald A. Denkhaus	CPRX	Restricted Stock Units	Options Exercise	-0.74%			-1,334	178,163	29 Dec 2025	Direct
Brian Elsbernd	CPRX	Common Stock, par value $0.001 per share	Tax liability	-1.07%			-2,623	242,501	29 Dec 2025	Direct
Brian Elsbernd	CPRX	Common Stock, par value $0.001 per share	Options Exercise	2.8%			6,667	245,124	29 Dec 2025	Direct
Brian Elsbernd	CPRX	Restricted Stock Units	Options Exercise	-0.69%			-6,667	956,142	29 Dec 2025	Direct
David S. Tierney	CPRX	Common Stock, par value $0.001 per share	Options Exercise	0.35%			1,334	383,314	29 Dec 2025	Direct
David S. Tierney	CPRX	Restricted Stock Units	Options Exercise	-0.74%			-1,334	178,163	29 Dec 2025	Direct
Preethi Sundaram	CPRX	Common Stock, par value $0.001 per share	Tax liability	-4.14%			-2,369	54,804	29 Dec 2025	Direct
Preethi Sundaram	CPRX	Common Stock, par value $0.001 per share	Options Exercise	13.2%			6,667	57,173	29 Dec 2025	Direct
Preethi Sundaram	CPRX	Restricted Stock Units	Options Exercise	-0.83%			-6,667	798,437	29 Dec 2025	Direct
Steve Miller	CPRX	Common stock, par value $0.001 per share	Options Exercise	1.3%			14,000	1,093,803	29 Dec 2025	Direct
Steve Miller	CPRX	Restricted Stock Units	Options Exercise	-0.94%			-14,000	1,471,649	29 Dec 2025	Direct
Molly Harper	CPRX	Common Stock, par value $0.001 per share	Options Exercise	56.5%			1,334	3,694	29 Dec 2025	Direct
Molly Harper	CPRX	Restricted Stock Units	Options Exercise	-1.04%			-1,334	127,163	29 Dec 2025	Direct
Patrick J. McEnany	CPRX	Common Stock, par value $0.001 per share	Tax liability	-0.16%			-6,786	4,171,559	29 Dec 2025	Direct
Patrick J. McEnany	CPRX	Common Stock, par value $0.001 per share	Options Exercise	0.63%			26,334	4,178,345	29 Dec 2025	Direct
Patrick J. McEnany	CPRX	Restricted Stock Units	Options Exercise	-1.4%			-26,334	1,851,948	29 Dec 2025	Direct
Richard J. Daly	CPRX	Common Stock, par value $0.001 per share	Tax liability	-0.22%			-524	239,738	29 Dec 2025	Direct
Richard J. Daly	CPRX	Common Stock, par value $0.001 per share	Options Exercise	0.56%			1,334	240,262	29 Dec 2025	Direct
Richard J. Daly	CPRX	Restricted Stock Units	Options Exercise	-0.05%			-1,334	2,660,644	29 Dec 2025	Direct
Jeffrey del Carmen	CPRX	Common Stock, par value $0.001 per share	Tax liability	-21.1%			-3,839	14,337	29 Dec 2025	Direct
Jeffrey del Carmen	CPRX	Common Stock, par value $0.001 per share	Options Exercise	91.2%			8,667	18,176	29 Dec 2025	Direct
Jeffrey del Carmen	CPRX	Restricted Stock Units	Options Exercise	-0.83%			-8,667	1,036,846	29 Dec 2025	Direct
Molly Harper	CPRX	Common stock, par value $0.001 per share	Sale	-91.9%	$621,920	$23.25	-26,746	2,360	12 Dec 2025	Direct
Molly Harper	CPRX	Common stock, par value $0.001 per share	Options Exercise	219.6%			20,000	29,106	12 Dec 2025	Direct
Molly Harper	CPRX	Options to purchase common stock	Options Exercise	-13.5%			-20,000	128,497	12 Dec 2025	Direct
Brian Elsbernd	CPRX	Common Stock, par value $0.001 per share	Tax liability	-1.15%			-2,780	238,457	08 Dec 2025	Direct
Brian Elsbernd	CPRX	Common Stock, par value $0.001 per share	Options Exercise	3.02%			7,067	241,237	08 Dec 2025	Direct
Brian Elsbernd	CPRX	Restricted Stock Units	Options Exercise	-0.73%			-7,067	962,809	08 Dec 2025	Direct
Steve Miller	CPRX	Common stock, par value $0.001 per share	Options Exercise	1.11%			11,873	1,079,803	08 Dec 2025	Direct
Steve Miller	CPRX	Restricted Stock Units	Options Exercise	-0.79%			-11,873	1,485,649	08 Dec 2025	Direct
David S. Tierney	CPRX	Common Stock, par value $0.001 per share	Options Exercise	0.37%			1,413	381,980	08 Dec 2025	Direct
David S. Tierney	CPRX	Restricted Stock Units	Options Exercise	-0.78%			-1,413	179,497	08 Dec 2025	Direct
Tamar Thompson	CPRX	Common Stock, par value $0.001 per share	Options Exercise	59.9%			1,413	3,773	08 Dec 2025	Direct
Tamar Thompson	CPRX	Restricted Stock Units	Options Exercise	-1.17%			-1,413	119,663	08 Dec 2025	Direct
Jeffrey del Carmen	CPRX	Common Stock, par value $0.001 per share	Tax liability	-20.8%			-2,492	9,509	08 Dec 2025	Direct
Jeffrey del Carmen	CPRX	Common Stock, par value $0.001 per share	Options Exercise	202.9%			8,039	12,001	08 Dec 2025	Direct
Jeffrey del Carmen	CPRX	Restricted Stock Units	Options Exercise	-0.76%			-8,039	1,045,513	08 Dec 2025	Direct
Patrick J. McEnany	CPRX	Common Stock, par value $0.001 per share	Options Exercise	0.09%			3,534	4,152,011	08 Dec 2025	Direct
Patrick J. McEnany	CPRX	Restricted Stock Units	Options Exercise	-0.19%			-3,534	1,878,282	08 Dec 2025	Direct
Molly Harper	CPRX	Common Stock, par value $0.001 per share	Options Exercise	18.4%			1,413	9,106	08 Dec 2025	Direct

* An asterisk sign (*) next to the price indicates that the price is likely invalid.