Invus Global Management, LLC - 25 Feb 2026 SCHEDULE 13G Report for Bicycle Therapeutics plc Ordinary Shares, nominal value GBP 0.01 per share (BCYC)

Filing Manager: Invus Global Management, LLC
Reporting Manager: Raymond Debbane
Security: Bicycle Therapeutics plc Ordinary Shares, nominal value GBP 0.01 per share
Symbol: BCYC
Shares outstanding: 49,984,905 shares
Disclosed Ownership: 3,149,049 shares
Ownership: 6.3%
Form type: SCHEDULE 13G
Filing time: 03 Mar 2026, 17:39:55 UTC
Date of event: 25 Feb 2026
SEC: View on sec.gov

Reporting Managers (8)

Name	Ownership	Shares Owned	sole voting power	Signature	Title
Invus Public Equities, L.P.	5.4%	2,719,707	2,719,707	/s/ Raymond Debbane	Raymond Debbane, President of Invus Public Equities Advisors, LLC, its general partner
Invus Public Equities Advisors, LLC	5.4%	2,719,707	2,719,707	/s/ Raymond Debbane	Raymond Debbane, President
Invus Global Management, LLC	5.4%	2,719,707	2,719,707	/s/ Raymond Debbane	Raymond Debbane, President
Siren, L.L.C.	5.4%	2,719,707	2,719,707	/s/ Raymond Debbane	Raymond Debbane, President
Avicenna Life Sci Master Fund LP	0.9%	429,342	429,342	/s/ Raymond Debbane	Raymond Debbane, Chief Executive Officer of Avicenna Life Sci Master GP LLC, its general partner
Avicenna Life Sci Master GP LLC	0.9%	429,342	429,342	/s/ Raymond Debbane	Raymond Debbane, Chief Executive Officer
Ulys, L.L.C.	0.9%	429,342	429,342	/s/ Raymond Debbane	Raymond Debbane, President
Raymond Debbane	6.3%	3,149,049	3,149,049	/s/ Raymond Debbane	Raymond Debbane