| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| RA Capital Management, L.P. | 9.9% | 7,989,820 | 0 | 7,989,820 | /s/ Peter Kolchinsky | By Peter Kolchinsky, Authorized Signatory | 0001346824 |
| Peter Kolchinsky | 9.9% | 7,989,820 | 0 | 7,989,820 | /s/ Peter Kolchinsky | Peter Kolchinsky | 0001384859 |
| Rajeev Shah | 9.9% | 7,989,820 | 0 | 7,989,820 | /s/ Rajeev Shah | Rajeev Shah | 0001619841 |
| RA Capital Healthcare Fund, L.P. | 9.8% | 7,823,558 | 0 | 7,823,558 | /s/ Peter Kolchinsky | By RA Capital Healthcare Fund GP, LLC, its General Partner, By Peter Kolchinsky, Manager | 0001315082 |