| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 10.1% | 6,443,286 | 0 | 6,443,286 | Kristin Mariani | Head of North America Compliance, CCO | |
| Janus Henderson Biotech Innovation Master Fund Ltd | 8.5% | 5,448,687 | 0 | 5,448,687 | Kristin Mariani | Head of North America Compliance, CCO |