| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| Polar Capital Holdings Plc | 5.65% | 6.71M | 6.71M | 0 | /s/ Nicholas Farren | Nicholas Farren - Chief Operating Officer | |
| Polar Capital LLP | 5.65% | 6.71M | 6.71M | 0 | /s/ Nicholas Farren | Nicholas Farren - Chief Operating Officer | |
| Polar Capital Funds PLC - Biotechnology Fund | 5.06% | 6M | 6M | 0 | /s/ Nicholas Farren | Nicholas Farren - Chief Operating Officer |