| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| Baker Bros. Advisors LP | 16% | 30,852,922 | 30,852,922 | 0 | /s/ Scott L. Lessing | By: Baker Bros. Advisors (GP) LLC, its general partner Scott L. Lessing/ President | 0001263508 |
| Baker Bros. Advisors (GP) LLC | 16% | 30,852,922 | 30,852,922 | 0 | /s/ Scott L. Lessing | Scott L. Lessing/ President | 0001580575 |
| Julian C. Baker | 16% | 31,211,000 | 31,211,000 | 0 | /s/ Julian C. Baker | Julian C. Baker | 0001087939 |
| Felix J. Baker | 16% | 31,213,417 | 31,213,417 | 0 | /s/ Felix J. Baker | Felix J. Baker | 0001087940 |
| FBB2, LLC | 0.01% | 14,755 | 14,755 | 0 | /s/ Julian C. Baker | Manager | 0001552222 |
| FBB3 LLC | 0.02% | 31,140 | 31,140 | 0 | /s/ Julian C. Baker | Manager | 0001625395 |
| FBB Associates | 0.02% | 33,410 | 33,410 | 0 | /s/ Julian C. Baker | Partner | 0001534842 |