BAKER BROS. ADVISORS LP - 12 Jun 2025 SCHEDULE 13D/A Report for Prelude Therapeutics Inc Common Stock, $0.0001 par value per share (PRLD)

Filing Manager: BAKER BROS. ADVISORS LP
Reporting Manager: Baker Bros. Advisors LP
Security: Prelude Therapeutics Inc Common Stock, $0.0001 par value per share
Symbol: PRLD
Shares outstanding: 43.7M shares
Disclosed Ownership: 10.3M shares
Ownership: 23.5%
Form type: SCHEDULE 13D/A
Filing time: 13 Jun 2025, 17:21:09 UTC
Date of event: 12 Jun 2025
SEC: View on sec.gov

Reporting Managers (4)

Name	Ownership	Shares Owned	sole voting power	Signature	Title	CIK
Baker Bros. Advisors LP	23.5%	10.3M	10.3M	/s/ Scott L. Lessing	By: Baker Bros. Advisors (GP) LLC, its general partner, Scott L. Lessing/ President	0001263508
Baker Bros. Advisors (GP) LLC	23.5%	10.3M	10.3M	/s/ Scott L. Lessing	Scott L. Lessing/ President	0001580575
Julian C. Baker	23.5%	10.3M	10.3M	/s/ Julian C. Baker	Julian C. Baker	0001087939
Felix J. Baker	23.5%	10.3M	10.3M	/s/ Felix J. Baker	Felix J. Baker	0001087940