| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| BB Biotech AG | 16% | 9,929,963 | 0 | 9,929,963 | /s/ Martin Gubler | Martin Gubler/Signatory Authority | |
| Biotech Target N.V. | 16% | 9,929,963 | 0 | 9,929,963 | /s/ Jan Bootsma | Jan Bootsma/Signatory Authority |