| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| RTW Investments, LP | 2.5% | 1,113,002 | 0 | 1,113,002 | /s/ Roderick Wong, M.D. | Roderick Wong, M.D., Managing Partner | |
| Roderick Wong, M.D. | 2.5% | 1,113,002 | 0 | 1,113,002 | /s/ Roderick Wong, M.D. | Roderick Wong, M.D. |