| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 2.1% | 2,592,057 | 0 | 2,592,057 | /s/ Carl L. Gordon | Carl L. Gordon/Member | |
| ORBIMED CAPITAL LLC | 2.6% | 3,230,797 | 3,230,797 | 0 | /s/ Carl L. Gordon | Carl L. Gordon/Member |