| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| OrbiMed Advisors LLC | 3.7% | 454,087 | 0 | 454,087 | /s/ Carl L. Gordon | Carl L. Gordon/Member | |
| OrbiMed Capital LLC | 5.9% | 718,200 | 718,200 | 0 | /s/ Carl L. Gordon | Carl L. Gordon/Member |