| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| Darwin Global Management, Ltd. | 8.1% | 3,027,704 | 0 | 3,027,704 | /s/ John Legge | John Legge, Director and Chief Financial Officer | |
| Trehan Abhishek | 8.1% | 3,027,704 | 0 | 3,027,704 | /s/ Dr. Abhishek Trehan | Dr. Abhishek Trehan, individually | |
| Darwin Global Master Fund, Ltd. | 7.8% | 2,928,575 | 0 | 2,928,575 | /s/ John Legge | By: Darwin Global Management, Ltd, its Investment Manager, By: John Legge, Director and Chief Financial Officer |