Et al Phillip Frost MD - 30 Sep 2025 SCHEDULE 13D/A Report for OPKO HEALTH, INC. Common Stock, par value $0.01 per share (OPK)

Filing manager: Et al Phillip Frost MD
Reporting owner: FROST PHILLIP MD ET AL
Security: OPKO HEALTH, INC. Common Stock, par value $0.01 per share
Beneficially owned shares: 252,884,406 shares
Large-stake signal: Form
SCHEDULE 13D/A
Active or control-oriented beneficial ownership filing.
Ownership
33%
Beneficial ownership of this reported class.
Shares
252,884,406 shares
Shares beneficially owned as disclosed.
Event date
30 Sep 2025
Date tied to the ownership event or amendment.
Accepted by SEC
01 Oct 2025
EDGAR acceptance date.
How to read this large-stake filing
Schedule 13D/G filings focus on beneficial ownership stakes, not a full portfolio.
Compare this filing with the holder history and issuer page before treating the percentage as a current position.
Use amendments to understand whether the disclosed stake increased, decreased, or changed reporting status.
Class ownership: 33%
Symbol: OPK
Shares outstanding: 770,989,043 shares
SEC form: SCHEDULE 13D/A
Accepted by SEC: 01 Oct 2025, 16:46:43 UTC
Event date: 30 Sep 2025
Prior SEC filing: 03 Apr 2025
Source filing: View source filing

Key filing fact

Et al Phillip Frost MD disclosed 33% ownership in OPKO HEALTH, INC. Common Stock, par value $0.01 per share (OPK) on 30 Sep 2025.

Key facts

Et al Phillip Frost MD filed SCHEDULE 13D/A for OPKO HEALTH, INC. Common Stock, par value $0.01 per share (OPK).
Disclosed ownership: 33%.
Date of event: 30 Sep 2025.

This page turns one Schedule 13D/G filing into a quick large-stake read before the raw reporting-person rows.
Use the linked SEC filing as the source of truth for ownership percentages, shares, and reporting-party details.

Backed by Schedule 13D/13G

Beneficial ownership values are sourced from the original SEC Schedule 13D/13G filing.

Reporting persons

Names, ownership percentages, voting power, signatures, titles, and CIKs as disclosed in this Schedule 13D/G filing.

Name	Ownership	Shares owned	Sole voting power	Shared voting power	Signature	Title	CIK
FROST PHILLIP MD ET AL	33%	252,884,406	250,032,576	2,851,830	/s/ Phillip Frost, M. D.	Phillip Frost, M.D., Individually	0000898860
Frost Gamma Investments Trust	28%	214,236,448	214,236,448	0	/s/ Phillip Frost, M. D.	Phillip Frost, M.D. / Sole Trustee	0001380896
Frost Nevada Investments Trust	3.9%	30,127,177	30,127,177	0	/s/ Phillip Frost, M. D.	Phillip Frost, M.D. / Sole Trustee	0001464124

CIK / CUSIP context first

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