Kyle Jenne - 15 Apr 2026 Form 4 Insider Report for IONIS PHARMACEUTICALS INC (IONS)

Reporting relationship: EVP, Chf GL Pdt Str Ofcr
Issuer ticker: IONS
Reported as of: 15 Apr 2026
Net transaction value: -$368,488
SEC form: 4
Accepted by SEC: 17 Apr 2026, 19:19:32 UTC
Prior SEC filing: 11 Mar 2026
Source filing: View source filing
Reporting owner signature: By: Patrick R. O'Neil, attorney-in-fact For: Kyle Jenne

Key filing fact

Kyle Jenne filed Form 4 for IONIS PHARMACEUTICALS INC (IONS) on 17 Apr 2026.

Key facts

This page summarizes Kyle Jenne's Form 4 filing for IONIS PHARMACEUTICALS INC (IONS).
3 reported transactions and 1 derivative row are listed below.
Accepted by SEC: 17 Apr 2026, 19:19.

Change

Previous filing in this sequence was filed on 11 Mar 2026.
Current net transaction value: -$368,488.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0001791857 Primary reporting owner

Jenne Kyle

Relationship: EVP, Chf GL Pdt Str Ofcr
Address: 2855 GAZELLE COURT, CARLSBAD
Signature: By: Patrick R. O'Neil, attorney-in-fact For: Kyle Jenne
Signature date: 17 Apr 2026

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

IONS transaction

Common Stock

Options Exercise

Transaction value
Shares: +12,226
Change %: +75%
Price: $0.000000^*
Shares after: 28,615
Date: 15 Apr 2026
Ownership: Direct
Footnotes: F1

IONS transaction

Common Stock

Sale

Transaction value: $368,488
Shares: -4,902
Change %: -17%
Price: $75.17
Shares after: 23,713
Date: 16 Apr 2026
Ownership: Direct
Footnotes: F2, F3

Reported derivative securities

Options, warrants, convertible securities, or similar derivative positions disclosed in the filing.

IONS transaction Derivative

Restricted Stock Unit

Options Exercise

Transaction value
Shares: -12,226
Change %: -14%
Price: $0.000000^*
Shares after: 74,402
Date: 15 Apr 2026
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 12,226
Exercise price: $0.000000
Footnotes: F4, F5

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Explanation of responses 5 footnotes

Footnote F1

Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award.

Footnote F2

The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice.

Footnote F3

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $75.06 to $75.26 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4.

Footnote F4

Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

Footnote F5

Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.