ARCH Venture Fund XIII, L.P. - 06 Mar 2026 Form 4 Insider Report for Lyell Immunopharma, Inc. (LYEL)

Reporting relationship: 10%+ Owner
Issuer ticker: LYEL
Reported as of: 06 Mar 2026
Net transaction value: +$12,499,985
SEC form: 4
Accepted by SEC: 09 Mar 2026, 16:34:54 UTC
Prior SEC filing: 29 Jul 2025
Source filing: View source filing
Reporting owner signature: ARCH Venture Partners XIII, LLC, By: /s/ Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director

Key filing fact

ARCH Venture Fund XIII, L.P. filed Form 4 for Lyell Immunopharma, Inc. (LYEL) on 09 Mar 2026.

Key facts

This page summarizes ARCH Venture Fund XIII, L.P.'s Form 4 filing for Lyell Immunopharma, Inc. (LYEL).
1 reported transaction and 0 derivative rows are listed below.
Accepted by SEC: 09 Mar 2026, 16:34.

Change

Previous filing in this sequence was filed on 29 Jul 2025.
Current net transaction value: +$12,499,985.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (9)

CIK 0002006772 Primary reporting owner

ARCH Venture Fund XIII, L.P.

Relationship: 10%+ Owner
Address: 8755 W. HIGGINS ROAD, SUITE 1025, CHICAGO
Signature: ARCH Venture Partners XIII, LLC, By: /s/ Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director
Signature date: 09 Mar 2026

CIK 0002016083

ARCH Venture Partners XIII, L.P.

Relationship: 10%+ Owner
Address: 8755 W. HIGGINS ROAD, SUITE 1025, CHICAGO
Signature: ARCH Venture Partners XIII, L.P., By: ARCH Venture Partners XIII, LLC, its General Partner, By: /s/ Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director
Signature date: 09 Mar 2026

CIK 0002016082

ARCH Venture Partners XIII, LLC

Relationship: 10%+ Owner
Address: 8755 W. HIGGINS ROAD, SUITE 1025, CHICAGO
Signature: ARCH Venture Fund XIII, L.P., By: ARCH Venture Partners XIII, L.P., its General Partner, By: ARCH Venture Partners XIII, LLC, its General Partner, By: /s/ Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director
Signature date: 09 Mar 2026

CIK 0001219039

CRANDELL KEITH

Relationship: 10%+ Owner
Address: 8755 W. HIGGINS ROAD, SUITE 1025, CHICAGO
Signature: Keith Crandell, Managing Director, By: /s/ Mark McDonnell, as Attorney-in-Fact
Signature date: 09 Mar 2026

CIK 0001219042

NELSEN ROBERT

Relationship: 10%+ Owner
Address: 8755 W. HIGGINS ROAD, SUITE 1025, CHICAGO
Signature: Robert Nelsen, Managing Director, By: /s/ Mark McDonnell, as Attorney-in-Fact
Signature date: 09 Mar 2026

CIK 0001569248

Burow Kristina

Relationship: 10%+ Owner
Address: 8755 W. HIGGINS ROAD,SUITE 1025, CHICAGO
Signature: Kristina Burow, Managing Director, By: /s/ Mark McDonnell, as Attorney-in-Fact
Signature date: 09 Mar 2026

CIK 0001229592

GILLIS STEVEN

Relationship: 10%+ Owner
Address: 8755 WEST HIGGINS ROAD, SUITE 1025, CHICAGO
Signature: Steven Gillis, Managing Director, By: /s/ Mark McDonnell, as Attorney-in-Fact
Signature date: 09 Mar 2026

CIK 0001202769

BERNS PAUL L

Relationship: 10%+ Owner
Address: 8755 W. HIGGINS ROAD, SUITE 1025, CHICAGO
Signature: Paul Berns, Managing Director, By: /s/ Mark McDonnell, as Attorney-in-Fact
Signature date: 09 Mar 2026

CIK 0001219043

BYBEE CLINTON

Relationship: 10%+ Owner
Address: 8755 W. HIGGINS ROAD, SUITE 1025, CHICAGO
Signature: Clinton Bybee, Managing Director, By: /s/ Mark McDonnell, as Attorney-in-Fact
Signature date: 09 Mar 2026

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

LYEL transaction

Common Stock

Purchase

Transaction value: $12,499,985
Shares: +488,090
Change %: +52%
Price: $25.61
Shares after: 1,426,528
Date: 06 Mar 2026
Ownership: See footnote
Footnotes: F1

LYEL holding

Common Stock

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 910,317
Date: 06 Mar 2026
Ownership: See footnote
Footnotes: F2

LYEL holding

Common Stock

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 910,317
Date: 06 Mar 2026
Ownership: See footnote
Footnotes: F3

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Explanation of responses 3 footnotes

Footnote F1

These shares are directly held by ARCH Venture Fund XIII, L.P. ("ARCH XIII"). ARCH Venture Partners XIII, L.P. ("AVP XIII LP") is the general partner of ARCH XIII. ARCH Venture Partners XIII, LLC ("AVP XIII LLC") is the general partner of AVP XIII LP. Keith Crandell, Robert Nelsen, Kristina Burow, Paul Berns and Steven Gillis are members of the investment committee of AVP XIII LLC (the "AVP XIII LLC Committee Members"). Each of AVP XIII LP and AVP XIII LLC may be deemed to beneficially own the shares held by ARCH XIII, and each of the AVP XIII LLC Committee Members may be deemed to share the power to direct the disposition and vote of the shares held by ARCH XIII. Each of AVP XIII LP, AVP XIII LLC and the AVP XIII LLC Committee Members disclaims beneficial ownership except to the extent of their pecuniary interest therein, if any.

Footnote F2

These shares are directly held by ARCH Venture Fund IX, L.P. ("ARCH IX"). ARCH Venture Partners IX, L.P. ("GPLP"), as the sole general partner of ARCH IX, may be deemed to beneficially own the shares held by ARCH IX. ARCH Venture Partners IX, LLC ("GPLLC"), as the sole general partner of GPLP, may be deemed to beneficially own the shares held by ARCH IX. As managing directors of GPLLC, each of Keith Crandell, Robert Nelsen and Clinton Bybee (the "ARCH Managing Directors"), may be deemed to beneficially own the shares held by ARCH IX. Each of GPLP, GPLLC and the ARCH Managing Directors disclaims beneficial ownership of the securities reported herein, except to the extent of their pecuniary interest therein, if any.

Footnote F3

These shares are directly held by ARCH Venture Fund IX Overage, L.P. ("ARCH Overage"). ARCH Venture Partners IX Overage, L.P. ("Overage GPLP"), as the sole general partner of ARCH Overage, may be deemed to beneficially own the shares held by ARCH Overage. GPLLC, as the sole general partner of Overage GPLP, may be deemed to beneficially own the shares held by ARCH Overage. As managing directors of GPLLC, each of the ARCH Managing Directors may be deemed to beneficially own the shares held by ARCH Overage. Each of Overage GPLP, GPLLC and the ARCH Managing Directors disclaims beneficial ownership of the securities reported herein, except to the extent of their pecuniary interest therein, if any.

SEC remarks

This Form 4 is one of two reports relating to the same transaction being filed jointly by ARCH Venture Partners XIII, LLC, ARCH Venture Partners XIII, L.P., ARCH Venture Fund XIII, L.P., Keith Crandell, Robert Nelsen, Kristina Burow, Steven Gillis, Paul Berns, Clinton Bybee, ARCH Venture Partners IX, LLC, ARCH Venture Partners IX, L.P., ARCH Venture Partners IX Overage, L.P., ARCH Venture Fund IX, L.P. and ARCH Venture Fund IX Overage, L.P.