Gil M. Labrucherie - 06 Feb 2026 Form 4 Insider Report for Septerna, Inc. (SEPN)

Reporting relationship: Chief Financial Officer
Issuer ticker: SEPN
Reported as of: 06 Feb 2026
Net transaction value: $0
SEC form: 4
Accepted by SEC: 10 Feb 2026, 19:10:50 UTC
Prior SEC filing: 21 Nov 2025
Source filing: View source filing
Reporting owner signature: /s/ Mark A. Wilson, Attorney-in-Fact

Key filing fact

Gil M. Labrucherie filed Form 4 for Septerna, Inc. (SEPN) on 10 Feb 2026.

Key facts

This page summarizes Gil M. Labrucherie's Form 4 filing for Septerna, Inc. (SEPN).
1 reported transaction and 1 derivative row are listed below.
Accepted by SEC: 10 Feb 2026, 19:10.

Change

Previous filing in this sequence was filed on 21 Nov 2025.
Current net transaction value: $0.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0001394875 Primary reporting owner

Labrucherie Gil M

Relationship: Chief Financial Officer
Address: C/O SEPTERNA, INC., 250 EAST GRAND AVENUE, SOUTH SAN FRANCISCO
Signature: /s/ Mark A. Wilson, Attorney-in-Fact
Signature date: 10 Feb 2026

Reported derivative securities

Options, warrants, convertible securities, or similar derivative positions disclosed in the filing.

SEPN transaction Derivative

Stock Option (Right to Buy)

Award

Transaction value: $0
Shares: +125,000
Change %
Price: $0.000000
Shares after: 125,000
Date: 06 Feb 2026
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 125,000
Exercise price: $25.41
Footnotes: F1

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Explanation of responses 1 footnote

Footnote F1

2/48th of the shares subject to such option shall vest and become exercisable on March 1, 2026 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC remarks

Exhibit 24.2 - Substitute Power of Attorney