Samir M. Gharib - 15 Dec 2025 Form 4 Insider Report for SPRUCE BIOSCIENCES, INC. (SPRB)

Reporting relationship: PRESIDENT AND CFO
Issuer ticker: SPRB
Reported as of: 15 Dec 2025
Net transaction value: -$29,203
SEC form: 4
Accepted by SEC: 17 Dec 2025, 16:58:51 UTC
Prior SEC filing: 15 Dec 2025
Source filing: View source filing
Reporting owner signature: /s/ Samir Gharib

Key filing fact

Samir M. Gharib filed Form 4 for SPRUCE BIOSCIENCES, INC. (SPRB) on 17 Dec 2025.

Key facts

This page summarizes Samir M. Gharib's Form 4 filing for SPRUCE BIOSCIENCES, INC. (SPRB).
6 reported transactions and 2 derivative rows are listed below.
Accepted by SEC: 17 Dec 2025, 16:58.

Change

Previous filing in this sequence was filed on 15 Dec 2025.
Current net transaction value: -$29,203.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0001533302 Primary reporting owner

Gharib Samir M.

Relationship: PRESIDENT AND CFO
Address: C/O SPRUCE BIOSCIENCES, INC., 611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO
Signature: /s/ Samir Gharib
Signature date: 17 Dec 2025

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

SPRB transaction

Common Stock

Options Exercise

Transaction value: $0
Shares: +496
Change %: +6.5%
Price: $0.000000
Shares after: 8,112
Date: 15 Dec 2025
Ownership: Direct
Footnotes: F1, F2

SPRB transaction

Common Stock

Tax liability

Transaction value: $14,359
Shares: -178
Change %: -2.2%
Price: $80.67
Shares after: 7,934
Date: 15 Dec 2025
Ownership: Direct
Footnotes: F1

SPRB transaction

Common Stock

Options Exercise

Transaction value: $0
Shares: +513
Change %: +6.5%
Price: $0.000000
Shares after: 8,447
Date: 15 Dec 2025
Ownership: Direct
Footnotes: F2, F3

SPRB transaction

Common Stock

Tax liability

Transaction value: $14,843
Shares: -184
Change %: -2.2%
Price: $80.67
Shares after: 8,263
Date: 15 Dec 2025
Ownership: Direct
Footnotes: F3

Reported derivative securities

Options, warrants, convertible securities, or similar derivative positions disclosed in the filing.

SPRB transaction Derivative

Restricted Stock Units

Options Exercise

Transaction value: $0
Shares: -496
Change %: -50%
Price: $0.000000
Shares after: 497
Date: 15 Dec 2025
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 496
Exercise price: $0.000000
Footnotes: F1, F2

SPRB transaction Derivative

Restricted Stock Units

Options Exercise

Transaction value: $0
Shares: -513
Change %: -33%
Price: $0.000000
Shares after: 1,027
Date: 15 Dec 2025
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 513
Exercise price: $0.000000
Footnotes: F2, F3

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Explanation of responses 3 footnotes

Footnote F1

On December 5, 2022, the Reporting Person was granted 1,986 time-based restricted stock units ("RSUs"), subject to a 4-year vesting schedule, with 25% of the total number of RSUs vested on December 15, 2023 (the "Annual Vesting Date") and 25% of the total number of RSUs to vest in annual installments on each anniversary of the Annual Vesting Date thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On December 15, 2025, 496 RSUs vested, with 178 shares withheld for taxes, resulting in a net issuance of 318 shares.

Footnote F2

Each RSU represents a contingent right to receive one share of common stock of the Issuer.

Footnote F3

On December 14, 2023, the Reporting Person was granted a total of 4,106 RSUs. 50% or 2,053 of the total RSUs are performance-based and all vested on December 10, 2024. An addition of 50% or 2,053 of the total RSUs are time-based. 25% of which vested on December 15, 2024, and in equal annual installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On December 15, 2025, 513 shares vested and 184 shares were withheld for taxes, resulting in a net issuance of 329 shares.