Adage Capital Management, L.P. - 16 Oct 2025 Form 4 Insider Report for Praxis Precision Medicines, Inc. (PRAX)

Reporting relationship: 10%+ Owner
Issuer ticker: PRAX
Reported as of: 16 Oct 2025
Net transaction value: +$33,198,124
SEC form: 4
Accepted by SEC: 17 Oct 2025, 16:10:45 UTC
Prior SEC filing: 19 Aug 2025
Source filing: View source filing
Reporting owner signature: /s/ Adage Capital Management, L.P.; By: its general partner Adage Capital Partners LLC; By its managing member Robert Atchinson

Key filing fact

Adage Capital Management, L.P. filed Form 4 for Praxis Precision Medicines, Inc. (PRAX) on 17 Oct 2025.

Key facts

This page summarizes Adage Capital Management, L.P.'s Form 4 filing for Praxis Precision Medicines, Inc. (PRAX).
10 reported transactions and 0 derivative rows are listed below.
Accepted by SEC: 17 Oct 2025, 16:10.

Change

Previous filing in this sequence was filed on 19 Aug 2025.
Current net transaction value: +$33,198,124.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (3)

CIK 0001535978 Primary reporting owner

Adage Capital Management, L.P.

Relationship: 10%+ Owner
Address: 200 CLARENDON STREET, 52ND FLOOR, BOSTON
Signature: /s/ Adage Capital Management, L.P.; By: its general partner Adage Capital Partners LLC; By its managing member Robert Atchinson
Signature date: 17 Oct 2025

CIK 0001403404

Atchinson Robert

Relationship: 10%+ Owner
Address: 200 CLARENDON STREET, 52ND FLOOR, BOSTON
Signature: /s/ Robert Atchinson
Signature date: 17 Oct 2025

CIK 0001403413

Gross Phillip

Relationship: 10%+ Owner
Address: 200 CLARENDON STREET, 52ND FLOOR, BOSTON
Signature: /s/ Phillip Gross
Signature date: 17 Oct 2025

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

PRAX transaction

Common Stock, $0.0001 par value per share ("Common Stock")

Sale

Transaction value: $1,134,032
Shares: +12,600
Change %: +0.54%
Price: $90.00
Shares after: 2,361,485
Date: 16 Oct 2025
Ownership: See footnotes
Footnotes: F1, F2, F3

PRAX transaction

Common Stock

Sale

Transaction value: $40,695
Shares: +447
Change %: +0.02%
Price: $91.04
Shares after: 2,361,038
Date: 16 Oct 2025
Ownership: See footnotes
Footnotes: F1, F2, F4

PRAX transaction

Common Stock

Sale

Transaction value: $125,441
Shares: +1,363
Change %: +0.06%
Price: $92.03
Shares after: 2,359,675
Date: 16 Oct 2025
Ownership: See footnotes
Footnotes: F1, F2, F5

PRAX transaction

Common Stock

Sale

Transaction value: $55,961
Shares: +559
Change %: +0.02%
Price: $100.11
Shares after: 2,359,116
Date: 16 Oct 2025
Ownership: See footnotes
Footnotes: F1, F2, F6

PRAX transaction

Common Stock

Sale

Transaction value: $2,755,987
Shares: +27,287
Change %: +1.2%
Price: $101.00
Shares after: 2,331,829
Date: 16 Oct 2025
Ownership: See footnotes
Footnotes: F1, F2

PRAX transaction

Common Stock

Sale

Transaction value: $26,077,375
Shares: +250,000
Change %: +14%
Price: $104.31
Shares after: 2,081,829
Date: 16 Oct 2025
Ownership: See footnotes
Footnotes: F1, F2, F7

PRAX transaction

Common Stock

Sale

Transaction value: $216,090
Shares: +1,661
Change %: +0.08%
Price: $130.10
Shares after: 2,080,168
Date: 16 Oct 2025
Ownership: See footnotes
Footnotes: F1, F2, F8

PRAX transaction

Common Stock

Sale

Transaction value: $64,108
Shares: +487
Change %: +0.02%
Price: $131.64
Shares after: 2,079,681
Date: 16 Oct 2025
Ownership: See footnotes
Footnotes: F1, F2, F9

PRAX transaction

Common Stock

Sale

Transaction value: $40,715
Shares: +308
Change %: +0.01%
Price: $132.19
Shares after: 2,079,373
Date: 16 Oct 2025
Ownership: See footnotes
Footnotes: F1, F2, F10

PRAX transaction

Common Stock

Sale

Transaction value: $2,687,720
Shares: +19,198
Change %: +0.94%
Price: $140.00
Shares after: 2,060,175
Date: 16 Oct 2025
Ownership: See footnotes
Footnotes: F1, F2, F11

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Section 16 status

Adage Capital Management, L.P. is no longer subject to Section 16 filing requirements. Form 4 or Form 5 obligations may still apply in specific circumstances.

Explanation of responses 11 footnotes

Footnote F1

The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership ("ACP"). Adage Capital Management, L.P., a Delaware limited partnership ("ACM"), serves as the investment manager of ACP and as such has discretion over the portfolio securities held by ACP. Robert Atchinson and Phillip Gross are the managing members of (i) Adage Capital Advisors, L.L.C., a Delaware limited liability company, managing member of Adage Capital Partners GP, L.L.C., a Delaware limited liability company, general partner of ACP and (ii) Adage Capital Partners LLC, a Delaware limited liability company, general partner of ACM.

Footnote F2

Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such Reporting Person's pecuniary interest in the securities, if any.

Footnote F3

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $90.0000 to $90.5000, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F4

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $91.000 to $91.9900, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F5

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $92.0000 to $92.2500, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F6

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $100.0400 to $100.6500, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F7

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $104.0000 to $104.3869, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F8

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $130.0000 to $130.9700, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F9

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $131.0000 to $131.9800, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F10

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $132.0000 to $132.5100, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F11

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $140.0000 to $140.0100, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.