Adage Capital Management, L.P. - Insider Trading & Ownership

Location: 200 Clarendon Street, 52 Nd Floor, Boston, MA
Summary: The estimated value of insider holdings of Adage Capital Management, L.P. is at least $333M dollars as of October 17, 2025. Adage Capital Management, L.P. is the 10%+ Owner of Praxis Precision Medicines, Inc. and owns shares of Praxis Precision Medicines, Inc. (PRAX) stock worth about $288M. Adage Capital Management, L.P. is the 10%+ Owner of Solid Biosciences Inc. and owns shares of Solid Biosciences Inc. (SLDB) stock worth about $32.1M. Adage Capital Management, L.P. is the 10%+ Owner of ABEONA THERAPEUTICS INC. and owns shares of ABEONA THERAPEUTICS INC. (ABEO) stock worth about $12M.
Signature: /s/ Adage Capital Management, L.P.; By: its general partner Adage Capital Partners LLC; By its managing member Robert Atchinson
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Ownership of Adage Capital Management, L.P.

Symbol	Company	Relationship	Holdings Value	Past Year Net Change	Change %	Report Period
PRAX	Praxis Precision Medicines, Inc.	10%+ Owner	$288M	+$33.2M	+13%	Oct 16, 2025
SLDB	Solid Biosciences Inc.	10%+ Owner	$32.1M	+$1.91M	+6.32%	Feb 18, 2025
ABEO	ABEONA THERAPEUTICS INC.	10%+ Owner	$12M			May 7, 2024
EYPT	EyePoint Pharmaceuticals, Inc.	10%+ Owner				Apr 18, 2024

Sym	Company	Class	Transaction	%	Value $	* Price $	Shares	Shares After	Date	Ownership

* An asterisk sign (*) next to the price indicates that the price is likely invalid.