Robert W. Duggan - 02 Jan 2025 Form 4 Insider Report for Summit Therapeutics Inc. (SMMT)

Footnote F1

The Reporting Person acquired beneficial ownership of these securities upon his marriage to the beneficial owner of the securities on December 18, 2024.

Footnote F2

The Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, if any, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 or for any other purpose.

Footnote F3

The option was granted on January 2, 2025. The shares underlying the option shall vest in four quarterly installments on March 31, June 30, September 30 and December 31 following election, subject to the reporting person remaining as a non-salaried director on each such vesting date.

Footnote F4

The option was issued to the reporting person pursuant to the Director Retainer Option Election Plan of issuer in lieu of retainer fees of $98,400.

Footnote F5

The option was granted to the Reporting Person's spouse on November 11, 2020 pursuant to the Issuer's Stock Incentive Plan, and are fully vested.

Footnote F6

The option was granted to the Reporting Person's spouse on November 22, 2020 pursuant to the Issuer's Stock Incentive Plan. The shares underlying the option are fully vested.

Footnote F7

The option was granted to the Reporting Person's spouse on December 15, 2021. The shares underlying the option are fully vested.

Footnote F8

The option was granted to the Reporting Person's spouse on October 13, 2023. The shares underlying the option shall vest in four equal annual installments, with the first such installment occurring on October 13, 2024. Note this does not include an additional 11,988,198 options which were granted to the Reporting Person's spouse on October 13, 2023 and are subject to the satisfaction of performance conditions based on market capitalization and revenue targets.

Footnote F9

These performance-based stock options vested on August 23, 2024, upon the attainment of the satisfaction of certain financial performance objectives. Note this does not include an additional 1,040,000 shares underlying options which were granted to the Reporting Person's spouse on June 28, 2022, that remain subject to the satisfaction of performance conditions.

Footnote F10

These performance-based stock options vested on August 23, 2024, upon the attainment of the satisfaction of certain financial performance objectives. Note this does not include an additional 400,000 shares underlying options which were granted to the Reporting Person's spouse on September 9, 2022 that remain subject to the satisfaction of performance conditions.

Footnote F11

These performance-based stock options vested on August 23, 2024, upon the attainment of the satisfaction of certain financial performance objectives. Note this does not include an additional 9,590,558 shares underlying options which were granted to the Reporting Person's spouse on October 13, 2023 that remain subject to the satisfaction of performance conditions.