Simeon George - 14 Oct 2026 Form 4 Insider Report for CRISPR Therapeutics AG (CRSP)

Reporting relationship: Director
Issuer ticker: CRSP
Reported as of: 14 Oct 2026
Net transaction value: -$720,373
SEC form: 4
Accepted by SEC: 16 Oct 2026, 17:45:51 UTC
Prior SEC filing: 29 Sep 2026
Source filing: View source filing
Reporting owner signature: /s/ Sasha Keough, attorney-in-fact for Simeon George

Filing notes and source

Key filing fact

Simeon George filed Form 4 for CRISPR Therapeutics AG (CRSP) on 16 Oct 2026.

Key facts

This page summarizes Simeon George's Form 4 filing for CRISPR Therapeutics AG (CRSP).
3 reported transactions and 1 derivative row are listed below.
Accepted by SEC: 16 Oct 2026, 17:45.

Change

Previous filing in this sequence was filed on 29 Sep 2026.
Current net transaction value: -$720,373.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0001595117 Primary reporting owner

George Simeon

Relationship: Director
Address: 929 MAIN STREET, SUITE 200, REDWOOD CITY
Signature: /s/ Sasha Keough, attorney-in-fact for Simeon George
Signature date: 16 Oct 2026

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

CRSP transaction

Common Shares

Options Exercise

Transaction value
Shares: +30,000
Change %
Price: $14.00^*
Shares after: 30,000
Date: 14 Oct 2026
Ownership: Direct

CRSP transaction

Common Shares

Sale

Transaction value: -$720,373
Shares: -14,514
Change %: -48%
Price: $49.63
Shares after: 15,486
Date: 14 Oct 2026
Ownership: Direct
Footnotes: F1, F2

CRSP holding

Common Shares

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 69,687
Date: 14 Oct 2026
Ownership: See Note 3
Footnotes: F3

CRSP holding

Common Shares

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 238,897
Date: 14 Oct 2026
Ownership: See Note 4
Footnotes: F4

CRSP holding

Common Shares

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 1,730,179
Date: 14 Oct 2026
Ownership: See Note 5
Footnotes: F5

Reported derivative securities

Options, warrants, convertible securities, or similar derivative positions disclosed in the filing.

CRSP transaction Derivative

Stock Option (Right to Buy)

Options Exercise

Transaction value
Shares: -30,000
Change %: -100%
Price: $0.000000^*
Shares after: 0
Date: 14 Oct 2026
Ownership: Direct
Underlying class: Common Shares
Underlying amount: 30,000
Exercise price: $14.00
Footnotes: F6

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Rule 10b5-1 trading plan

These transactions were reported as open-market trades under a Rule 10b5-1 plan. The plan lets an insider set trading instructions in advance, which can reduce the risk of trading while in possession of material nonpublic information.

Original filing language: transaction made pursuant to a contract, instruction, or written plan intended to satisfy Rule 10b5-1(c).

Explanation of responses 6 footnotes

Footnote F1

The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 12, 2025.

Footnote F2

The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.45 to $50.44 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Footnote F3

The Reporting Person is the sole managing member of SR One Capital Management, LLC ("SR One Capital Management"), which is the sole general partner of SR One Capital Partners II, LP ("SR One Partners II"). SR One Partners II is the sole general partner of SR One Capital Fund II Aggregator, LP ("SR One Fund II Aggregator"), which is the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended ("Section 16"), or otherwise of such portion of the securities held by SR One Fund II Aggregator in which the Reporting Person has no pecuniary interest.

Footnote F4

The Reporting Person is the sole managing member of SR One Capital Management, which is the sole general partner of SR One Capital Opportunities Partners I, LP ("SR One Opportunities Partners I"). SR One Opportunities Partners I is the sole general partner of SR One Capital Opportunities Fund I, LP ("SR One Opportunities Fund I"), which is the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 or otherwise of such portion of the securities held by SR One Opportunities Fund I in which the Reporting Person has no pecuniary interest.

Footnote F5

The Reporting Person is the sole managing member of SR One Capital Management, which is the sole general partner of SR One Capital SMA Partners, LP ("SMA Partners"). SMA Partners is the sole general partner of AMZL, LP ("AMZL"), which is the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 or otherwise of such portion of the securities held by AMZL in which the Reporting Person has no pecuniary interest.

Footnote F6

This option was granted on October 18, 2016 with respect to 30,000 Common Shares with 100% of the shares vesting in 36 equal monthly installments beginning October 31, 2016.