Nello Mainolfi - 01 Oct 2026 Form 4 Insider Report for Kymera Therapeutics, Inc. (KYMR)

Reporting relationship: Chief Executive Officer, Director
Issuer ticker: KYMR
Reported as of: 01 Oct 2026
Net transaction value: -$3,413,917
SEC form: 4
Accepted by SEC: 01 Oct 2026, 17:20:12 UTC
Prior SEC filing: 07 Jul 2026
Source filing: View source filing
Reporting owner signature: /s/ Bruce Jacobs, as Attorney-in-Fact

Filing notes and source

Key filing fact

Nello Mainolfi filed Form 4 for Kymera Therapeutics, Inc. (KYMR) on 01 Oct 2026.

Key facts

This page summarizes Nello Mainolfi's Form 4 filing for Kymera Therapeutics, Inc. (KYMR).
8 reported transactions and 1 derivative row are listed below.
Accepted by SEC: 01 Oct 2026, 17:20.

Change

Previous filing in this sequence was filed on 07 Jul 2026.
Current net transaction value: -$3,413,917.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0001821189 Primary reporting owner

Mainolfi Nello

Relationship: Chief Executive Officer, Director
Address: C/O KYMERA THERAPEUTICS, INC., 500 NORTH BEACON STREET, 4TH FLOOR, WATERTOWN
Signature: /s/ Bruce Jacobs, as Attorney-in-Fact
Signature date: 01 Oct 2026

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

KYMR transaction

Common Stock

Options Exercise

Transaction value
Shares: +30,000
Change %: +4.5%
Price: $2.08^*
Shares after: 696,568
Date: 01 Oct 2026
Ownership: Direct
Footnotes: F1

KYMR transaction

Common Stock

Sale

Transaction value: -$392,826
Shares: -3,525
Change %: -0.51%
Price: $111.44
Shares after: 693,043
Date: 01 Oct 2026
Ownership: Direct
Footnotes: F1, F2

KYMR transaction

Common Stock

Sale

Transaction value: -$618,985
Shares: -5,506
Change %: -0.79%
Price: $112.42
Shares after: 687,537
Date: 01 Oct 2026
Ownership: Direct
Footnotes: F1, F3

KYMR transaction

Common Stock

Sale

Transaction value: -$552,158
Shares: -4,876
Change %: -0.71%
Price: $113.24
Shares after: 682,661
Date: 01 Oct 2026
Ownership: Direct
Footnotes: F1, F4

KYMR transaction

Common Stock

Sale

Transaction value: -$869,782
Shares: -7,601
Change %: -1.1%
Price: $114.43
Shares after: 675,060
Date: 01 Oct 2026
Ownership: Direct
Footnotes: F1, F5

KYMR transaction

Common Stock

Sale

Transaction value: -$949,742
Shares: -8,230
Change %: -1.2%
Price: $115.40
Shares after: 666,830
Date: 01 Oct 2026
Ownership: Direct
Footnotes: F1, F6

KYMR transaction

Common Stock

Sale

Transaction value: -$30,423
Shares: -262
Change %: -0.04%
Price: $116.12
Shares after: 666,568
Date: 01 Oct 2026
Ownership: Direct
Footnotes: F1, F7

Reported derivative securities

Options, warrants, convertible securities, or similar derivative positions disclosed in the filing.

KYMR transaction Derivative

Stock Option (Right to Buy)

Options Exercise

Transaction value
Shares: -30,000
Change %: -33%
Price: $0.000000^*
Shares after: 60,000
Date: 01 Oct 2026
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 30,000
Exercise price: $2.08
Footnotes: F1, F8

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Rule 10b5-1 trading plan

These transactions were reported as open-market trades under a Rule 10b5-1 plan. The plan lets an insider set trading instructions in advance, which can reduce the risk of trading while in possession of material nonpublic information.

Original filing language: transaction made pursuant to a contract, instruction, or written plan intended to satisfy Rule 10b5-1(c).

Explanation of responses 8 footnotes

Footnote F1

These transactions were effected pursuant to a Rule 10b5-1 trading plan dated March 24, 2026 adopted by the reporting person.

Footnote F2

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $110.93 to $111.90, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Footnote F3

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $111.97 to $112.92 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Footnote F4

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $112.95 to $113.88 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Footnote F5

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $113.94 to $114.91 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Footnote F6

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $114.94 to $115.92, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Footnote F7

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $116.09 to $116.16 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Footnote F8

The shares underlying this stock option are fully vested and exercisable.