Andrew J. Schwab - 22 Sep 2026 Form 4 Insider Report for Skye Bioscience, Inc. (SKYE)

Reporting relationship: Director, 10%+ Owner
Issuer ticker: SKYE
Reported as of: 22 Sep 2026
Net transaction value: -$239,555
SEC form: 4
Accepted by SEC: 24 Sep 2026, 16:31:57 UTC
Prior SEC filing: 18 Sep 2026
Source filing: View source filing
Reporting owner signature: /s/ Andrew J. Schwab

Key filing fact

Andrew J. Schwab filed Form 4 for Skye Bioscience, Inc. (SKYE) on 24 Sep 2026.

Key facts

This page summarizes Andrew J. Schwab's Form 4 filing for Skye Bioscience, Inc. (SKYE).
4 reported transactions and 0 derivative rows are listed below.
Accepted by SEC: 24 Sep 2026, 16:31.

Change

Previous filing in this sequence was filed on 18 Sep 2026.
Current net transaction value: -$239,555.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0001598549 Primary reporting owner

Schwab Andrew J.

Relationship: Director, 10%+ Owner
Address: C/O 5AM VENTURE MANAGEMENT, LLC, 4 EMBARCADERO CENTER, SUITE 3110, SAN FRANCISCO
Signature: /s/ Andrew J. Schwab
Signature date: 24 Sep 2026

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

SKYE transaction

Common Stock

Sale

Transaction value: $45,560
Shares: -27,612
Change %: -19%
Price: $1.65
Shares after: 114,851
Date: 22 Sep 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F1

SKYE transaction

Common Stock

Sale

Transaction value: $1,795
Shares: -1,088
Change %: -19%
Price: $1.65
Shares after: 4,528
Date: 22 Sep 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F2

SKYE transaction

Common Stock

Sale

Transaction value: $184,910
Shares: -114,851
Change %: -100%
Price: $1.61
Shares after: 0
Date: 23 Sep 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F1, F3

SKYE transaction

Common Stock

Sale

Transaction value: $7,290
Shares: -4,528
Change %: -100%
Price: $1.61
Shares after: 0
Date: 23 Sep 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F2, F3

SKYE holding

Common Stock

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 981,269
Date: 22 Sep 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F4

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Explanation of responses 4 footnotes

Footnote F1

The securities are directly held by 5AM Ventures II, L.P. ("Ventures II"). 5AM Partners II, LLC ("Partners II") is the sole general partner of Ventures II. The Reporting Person is a managing member of Partners II and may be deemed to have shared voting and investment power over the shares beneficially owned by Ventures II. The Reporting Person disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein.

Footnote F2

The securities are directly held by 5AM Co-Investors II, L.P. ("Co-Investors II"). Partners II is the sole general partner of Co-Investors II. The Reporting Person is a managing member of Partners II and may be deemed to have shared voting and investment power over the shares beneficially owned by Co-Investors II. The Reporting Person disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein.

Footnote F3

The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $1.60 to $1.77 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Footnote F4

The securities are directly held by 5AM Ventures VII, L.P. ("Ventures VII"). 5AM Partners VII, LLC ("Partners VII") is the sole general partner of Ventures VII. The Reporting Person is a managing member of Partners VII and may be deemed to have shared voting and investment power over the shares beneficially owned by Ventures VII. The Reporting Person disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein.