5AM Partners VII, LLC - 18 Aug 2026 Form 4 Insider Report for Skye Bioscience, Inc. (SKYE)

Reporting relationship: 10%+ Owner
Issuer ticker: SKYE
Reported as of: 18 Aug 2026
Net transaction value: -$140,313
SEC form: 4
Accepted by SEC: 20 Aug 2026, 17:57:08 UTC
Prior SEC filing: 22 Aug 2025
Source filing: View source filing
Reporting owner signature: 5AM Partners VII, LLC, By /s/ Andrew J. Schwab, Managing Member

Key filing fact

5AM Partners VII, LLC filed Form 4 for Skye Bioscience, Inc. (SKYE) on 20 Aug 2026.

Key facts

This page summarizes 5AM Partners VII, LLC's Form 4 filing for Skye Bioscience, Inc. (SKYE).
9 reported transactions and 0 derivative rows are listed below.
Accepted by SEC: 20 Aug 2026, 17:57.

Change

Previous filing in this sequence was filed on 22 Aug 2025.
Current net transaction value: -$140,313.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (8)

CIK 0001873545 Primary reporting owner

5AM Partners VII, LLC

Relationship: 10%+ Owner
Address: 4 EMBARCADERO CENTER, SUITE 3110, SAN FRANCISCO
Signature: 5AM Partners VII, LLC, By /s/ Andrew J. Schwab, Managing Member
Signature date: 20 Aug 2026

CIK 0001844435

5AM Ventures VII, L.P.

Relationship: 10%+ Owner
Address: 4 EMBARCADERO CENTER, SUITE 3110, SAN FRANCISCO
Signature: 5AM Ventures VII, L.P., By: 5AM Partners VII, LLC, its General Partner, By /s/ Andrew J. Schwab, Managing Member
Signature date: 20 Aug 2026

CIK 0001555952

5AM Partners II, LLC

Relationship: 10%+ Owner
Address: 4 EMBARCADERO CENTER, SUITE 3110, SAN FRANCISCO
Signature: 5AM Partners II, LLC, By /s/ Andrew J. Schwab, Managing Member
Signature date: 20 Aug 2026

CIK 0001386509

5AM Ventures II LP

Relationship: 10%+ Owner
Address: 4 EMBARCADERO CENTER, SUITE 3110, SAN FRANCISCO
Signature: 5AM Ventures II, L.P., By: 5AM Partners II, LLC, its General Partner, By /s/ Andrew J. Schwab, Managing Member
Signature date: 20 Aug 2026

CIK 0001390376

5AM CO-INVESTORS II LP

Relationship: 10%+ Owner
Address: 4 EMBARCADERO CENTER, SUITE 3110, SAN FRANCISCO
Signature: 5AM Co-Investors II, L.P., By: 5AM Partners II, LLC, its General Partner, By /s/ Andrew J. Schwab, Managing Member
Signature date: 20 Aug 2026

CIK 0001240357

DIEKMAN JOHN D

Relationship: 10%+ Owner
Address: 4 EMBARCADERO CENTER, SUITE 3110, SAN FRANCISCO
Signature: /s/ John Diekman
Signature date: 20 Aug 2026

CIK 0001664281

PARMAR KUSH

Relationship: 10%+ Owner
Address: 4 EMBARCADERO CENTER, SUITE 3110, SAN FRANCISCO
Signature: /s/ Kush Parmar
Signature date: 20 Aug 2026

CIK 0001219014

ROCKLAGE SCOTT M

Relationship: 10%+ Owner
Address: 4 EMBARCADERO CENTER, SUITE 3110, SAN FRANCISCO
Signature: /s/ Scott M. Rocklage
Signature date: 20 Aug 2026

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

SKYE transaction

Common Stock

Sale

Transaction value: $17,134
Shares: -45,090
Change %: -3.1%
Price: $0.3800
Shares after: 1,411,974
Date: 18 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F1, F2

SKYE transaction

Common Stock

Sale

Transaction value: $17,134
Shares: -45,090
Change %: -3.1%
Price: $0.3800
Shares after: 1,411,974
Date: 18 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F1, F2

SKYE transaction

Common Stock

Sale

Transaction value: $17,134
Shares: -45,090
Change %: -3.1%
Price: $0.3800
Shares after: 1,411,974
Date: 18 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F1, F2

SKYE transaction

Common Stock

Sale

Transaction value: $17,134
Shares: -45,090
Change %: -3.1%
Price: $0.3800
Shares after: 1,411,974
Date: 18 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F1, F2

SKYE transaction

Common Stock

Sale

Transaction value: $17,134
Shares: -45,090
Change %: -3.1%
Price: $0.3800
Shares after: 1,411,974
Date: 18 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F1, F2

SKYE transaction

Common Stock

Sale

Transaction value: $17,134
Shares: -45,090
Change %: -3.1%
Price: $0.3800
Shares after: 1,411,974
Date: 18 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F1, F2

SKYE transaction

Common Stock

Sale

Transaction value: $17,134
Shares: -45,090
Change %: -3.1%
Price: $0.3800
Shares after: 1,411,974
Date: 18 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F1, F2

SKYE transaction

Common Stock

Sale

Transaction value: $17,134
Shares: -45,090
Change %: -3.1%
Price: $0.3800
Shares after: 1,411,974
Date: 18 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F1, F2

SKYE transaction

Common Stock

Sale

Transaction value: $695
Shares: -1,830
Change %: -3.2%
Price: $0.3800
Shares after: 55,663
Date: 18 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F1, F3

SKYE transaction

Common Stock

Sale

Transaction value: $695
Shares: -1,830
Change %: -3.2%
Price: $0.3800
Shares after: 55,663
Date: 18 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F1, F3

SKYE transaction

Common Stock

Sale

Transaction value: $695
Shares: -1,830
Change %: -3.2%
Price: $0.3800
Shares after: 55,663
Date: 18 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F1, F3

SKYE transaction

Common Stock

Sale

Transaction value: $695
Shares: -1,830
Change %: -3.2%
Price: $0.3800
Shares after: 55,663
Date: 18 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F1, F3

SKYE transaction

Common Stock

Sale

Transaction value: $695
Shares: -1,830
Change %: -3.2%
Price: $0.3800
Shares after: 55,663
Date: 18 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F1, F3

SKYE transaction

Common Stock

Sale

Transaction value: $695
Shares: -1,830
Change %: -3.2%
Price: $0.3800
Shares after: 55,663
Date: 18 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F1, F3

SKYE transaction

Common Stock

Sale

Transaction value: $695
Shares: -1,830
Change %: -3.2%
Price: $0.3800
Shares after: 55,663
Date: 18 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F1, F3

SKYE transaction

Common Stock

Sale

Transaction value: $695
Shares: -1,830
Change %: -3.2%
Price: $0.3800
Shares after: 55,663
Date: 18 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F1, F3

SKYE transaction

Common Stock

Sale

Transaction value: $96,170
Shares: -253,080
Change %: -3.1%
Price: $0.3800
Shares after: 7,914,126
Date: 18 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F1, F4

SKYE transaction

Common Stock

Sale

Transaction value: $96,170
Shares: -253,080
Change %: -3.1%
Price: $0.3800
Shares after: 7,914,126
Date: 18 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F1, F4

SKYE transaction

Common Stock

Sale

Transaction value: $96,170
Shares: -253,080
Change %: -3.1%
Price: $0.3800
Shares after: 7,914,126
Date: 18 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F1, F4

SKYE transaction

Common Stock

Sale

Transaction value: $96,170
Shares: -253,080
Change %: -3.1%
Price: $0.3800
Shares after: 7,914,126
Date: 18 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F1, F4

SKYE transaction

Common Stock

Sale

Transaction value: $96,170
Shares: -253,080
Change %: -3.1%
Price: $0.3800
Shares after: 7,914,126
Date: 18 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F1, F4

SKYE transaction

Common Stock

Sale

Transaction value: $96,170
Shares: -253,080
Change %: -3.1%
Price: $0.3800
Shares after: 7,914,126
Date: 18 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F1, F4

SKYE transaction

Common Stock

Sale

Transaction value: $96,170
Shares: -253,080
Change %: -3.1%
Price: $0.3800
Shares after: 7,914,126
Date: 18 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F1, F4

SKYE transaction

Common Stock

Sale

Transaction value: $96,170
Shares: -253,080
Change %: -3.1%
Price: $0.3800
Shares after: 7,914,126
Date: 18 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F1, F4

SKYE transaction

Common Stock

Sale

Transaction value: $3,589
Shares: -10,255
Change %: -0.73%
Price: $0.3500
Shares after: 1,401,719
Date: 19 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F2, F5

SKYE transaction

Common Stock

Sale

Transaction value: $3,589
Shares: -10,255
Change %: -0.73%
Price: $0.3500
Shares after: 1,401,719
Date: 19 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F2, F5

SKYE transaction

Common Stock

Sale

Transaction value: $3,589
Shares: -10,255
Change %: -0.73%
Price: $0.3500
Shares after: 1,401,719
Date: 19 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F2, F5

SKYE transaction

Common Stock

Sale

Transaction value: $3,589
Shares: -10,255
Change %: -0.73%
Price: $0.3500
Shares after: 1,401,719
Date: 19 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F2, F5

SKYE transaction

Common Stock

Sale

Transaction value: $3,589
Shares: -10,255
Change %: -0.73%
Price: $0.3500
Shares after: 1,401,719
Date: 19 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F2, F5

SKYE transaction

Common Stock

Sale

Transaction value: $3,589
Shares: -10,255
Change %: -0.73%
Price: $0.3500
Shares after: 1,401,719
Date: 19 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F2, F5

SKYE transaction

Common Stock

Sale

Transaction value: $3,589
Shares: -10,255
Change %: -0.73%
Price: $0.3500
Shares after: 1,401,719
Date: 19 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F2, F5

SKYE transaction

Common Stock

Sale

Transaction value: $3,589
Shares: -10,255
Change %: -0.73%
Price: $0.3500
Shares after: 1,401,719
Date: 19 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F2, F5

SKYE transaction

Common Stock

Sale

Transaction value: $143
Shares: -409
Change %: -0.73%
Price: $0.3500
Shares after: 55,254
Date: 19 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F3, F5

SKYE transaction

Common Stock

Sale

Transaction value: $143
Shares: -409
Change %: -0.73%
Price: $0.3500
Shares after: 55,254
Date: 19 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F3, F5

SKYE transaction

Common Stock

Sale

Transaction value: $143
Shares: -409
Change %: -0.73%
Price: $0.3500
Shares after: 55,254
Date: 19 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F3, F5

SKYE transaction

Common Stock

Sale

Transaction value: $143
Shares: -409
Change %: -0.73%
Price: $0.3500
Shares after: 55,254
Date: 19 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F3, F5

SKYE transaction

Common Stock

Sale

Transaction value: $143
Shares: -409
Change %: -0.73%
Price: $0.3500
Shares after: 55,254
Date: 19 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F3, F5

SKYE transaction

Common Stock

Sale

Transaction value: $143
Shares: -409
Change %: -0.73%
Price: $0.3500
Shares after: 55,254
Date: 19 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F3, F5

SKYE transaction

Common Stock

Sale

Transaction value: $143
Shares: -409
Change %: -0.73%
Price: $0.3500
Shares after: 55,254
Date: 19 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F3, F5

SKYE transaction

Common Stock

Sale

Transaction value: $143
Shares: -409
Change %: -0.73%
Price: $0.3500
Shares after: 55,254
Date: 19 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F3, F5

SKYE transaction

Common Stock

Sale

Transaction value: $20,117
Shares: -57,476
Change %: -0.73%
Price: $0.3500
Shares after: 7,856,650
Date: 19 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F4, F5

SKYE transaction

Common Stock

Sale

Transaction value: $20,117
Shares: -57,476
Change %: -0.73%
Price: $0.3500
Shares after: 7,856,650
Date: 19 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F4, F5

SKYE transaction

Common Stock

Sale

Transaction value: $20,117
Shares: -57,476
Change %: -0.73%
Price: $0.3500
Shares after: 7,856,650
Date: 19 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F4, F5

SKYE transaction

Common Stock

Sale

Transaction value: $20,117
Shares: -57,476
Change %: -0.73%
Price: $0.3500
Shares after: 7,856,650
Date: 19 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F4, F5

SKYE transaction

Common Stock

Sale

Transaction value: $20,117
Shares: -57,476
Change %: -0.73%
Price: $0.3500
Shares after: 7,856,650
Date: 19 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F4, F5

SKYE transaction

Common Stock

Sale

Transaction value: $20,117
Shares: -57,476
Change %: -0.73%
Price: $0.3500
Shares after: 7,856,650
Date: 19 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F4, F5

SKYE transaction

Common Stock

Sale

Transaction value: $20,117
Shares: -57,476
Change %: -0.73%
Price: $0.3500
Shares after: 7,856,650
Date: 19 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F4, F5

SKYE transaction

Common Stock

Sale

Transaction value: $20,117
Shares: -57,476
Change %: -0.73%
Price: $0.3500
Shares after: 7,856,650
Date: 19 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F4, F5

SKYE transaction

Common Stock

Sale

Transaction value: $371
Shares: -1,159
Change %: -0.08%
Price: $0.3200
Shares after: 1,400,560
Date: 20 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F2

SKYE transaction

Common Stock

Sale

Transaction value: $371
Shares: -1,159
Change %: -0.08%
Price: $0.3200
Shares after: 1,400,560
Date: 20 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F2

SKYE transaction

Common Stock

Sale

Transaction value: $371
Shares: -1,159
Change %: -0.08%
Price: $0.3200
Shares after: 1,400,560
Date: 20 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F2

SKYE transaction

Common Stock

Sale

Transaction value: $371
Shares: -1,159
Change %: -0.08%
Price: $0.3200
Shares after: 1,400,560
Date: 20 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F2

SKYE transaction

Common Stock

Sale

Transaction value: $371
Shares: -1,159
Change %: -0.08%
Price: $0.3200
Shares after: 1,400,560
Date: 20 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F2

SKYE transaction

Common Stock

Sale

Transaction value: $371
Shares: -1,159
Change %: -0.08%
Price: $0.3200
Shares after: 1,400,560
Date: 20 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F2

SKYE transaction

Common Stock

Sale

Transaction value: $371
Shares: -1,159
Change %: -0.08%
Price: $0.3200
Shares after: 1,400,560
Date: 20 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F2

SKYE transaction

Common Stock

Sale

Transaction value: $371
Shares: -1,159
Change %: -0.08%
Price: $0.3200
Shares after: 1,400,560
Date: 20 Aug 2026
Ownership: By 5AM Ventures II, L.P.
Footnotes: F2

SKYE transaction

Common Stock

Sale

Transaction value: $14.72
Shares: -46
Change %: -0.08%
Price: $0.3200
Shares after: 55,208
Date: 20 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F3

SKYE transaction

Common Stock

Sale

Transaction value: $14.72
Shares: -46
Change %: -0.08%
Price: $0.3200
Shares after: 55,208
Date: 20 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F3

SKYE transaction

Common Stock

Sale

Transaction value: $14.72
Shares: -46
Change %: -0.08%
Price: $0.3200
Shares after: 55,208
Date: 20 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F3

SKYE transaction

Common Stock

Sale

Transaction value: $14.72
Shares: -46
Change %: -0.08%
Price: $0.3200
Shares after: 55,208
Date: 20 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F3

SKYE transaction

Common Stock

Sale

Transaction value: $14.72
Shares: -46
Change %: -0.08%
Price: $0.3200
Shares after: 55,208
Date: 20 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F3

SKYE transaction

Common Stock

Sale

Transaction value: $14.72
Shares: -46
Change %: -0.08%
Price: $0.3200
Shares after: 55,208
Date: 20 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F3

SKYE transaction

Common Stock

Sale

Transaction value: $14.72
Shares: -46
Change %: -0.08%
Price: $0.3200
Shares after: 55,208
Date: 20 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F3

SKYE transaction

Common Stock

Sale

Transaction value: $14.72
Shares: -46
Change %: -0.08%
Price: $0.3200
Shares after: 55,208
Date: 20 Aug 2026
Ownership: By 5AM Co-Investors II, L.P.
Footnotes: F3

SKYE transaction

Common Stock

Sale

Transaction value: $2,078
Shares: -6,495
Change %: -0.08%
Price: $0.3200
Shares after: 7,850,155
Date: 20 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F4

SKYE transaction

Common Stock

Sale

Transaction value: $2,078
Shares: -6,495
Change %: -0.08%
Price: $0.3200
Shares after: 7,850,155
Date: 20 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F4

SKYE transaction

Common Stock

Sale

Transaction value: $2,078
Shares: -6,495
Change %: -0.08%
Price: $0.3200
Shares after: 7,850,155
Date: 20 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F4

SKYE transaction

Common Stock

Sale

Transaction value: $2,078
Shares: -6,495
Change %: -0.08%
Price: $0.3200
Shares after: 7,850,155
Date: 20 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F4

SKYE transaction

Common Stock

Sale

Transaction value: $2,078
Shares: -6,495
Change %: -0.08%
Price: $0.3200
Shares after: 7,850,155
Date: 20 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F4

SKYE transaction

Common Stock

Sale

Transaction value: $2,078
Shares: -6,495
Change %: -0.08%
Price: $0.3200
Shares after: 7,850,155
Date: 20 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F4

SKYE transaction

Common Stock

Sale

Transaction value: $2,078
Shares: -6,495
Change %: -0.08%
Price: $0.3200
Shares after: 7,850,155
Date: 20 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F4

SKYE transaction

Common Stock

Sale

Transaction value: $2,078
Shares: -6,495
Change %: -0.08%
Price: $0.3200
Shares after: 7,850,155
Date: 20 Aug 2026
Ownership: By 5AM Ventures VII, L.P.
Footnotes: F4

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Explanation of responses 5 footnotes

Footnote F1

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $0.35 to $0.41 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Footnote F2

The securities are directly held by 5AM Ventures II, L.P. ("Ventures II"). 5AM Partners II, LLC ("Partners II") is the sole general partner of Ventures II. Dr. John Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are the managing members of Partners II and may be deemed to have shared voting and investment power over the securities beneficially owned by Ventures II. Each of Partners II, Dr. Diekman and Dr. Rocklage disclaims beneficial ownership of such securities except to the extent of its or his respective pecuniary interest therein. Mr. Schwab is a director of the Issuer and files separate Section 16 reports.

Footnote F3

The securities are directly held by 5AM Co-Investors II, L.P. ("Co-Investors II"). Partners II is the sole general partner of Co-Investors II. Dr. John Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are the managing members of Partners II and may be deemed to have shared voting and investment power over the securities beneficially owned by Co-Investors II. Each of Partners II, Dr. Diekman and Dr. Rocklage disclaims beneficial ownership of such shares except to the extent of its or his respective pecuniary interest therein. Mr. Schwab is a director of the Issuer and files separate Section 16 reports.

Footnote F4

The securities are directly held by 5AM Ventures VII, L.P. ("Ventures VII"). 5AM Partners VII, LLC ("Partners VII") is the sole general partner of Ventures VII. Dr. Kush Parmar and Andrew J. Schwab are the managing members of Partners VII and may be deemed to have shared voting and investment power over the securities beneficially owned by Ventures VII. Each of Partners VII and Dr. Parmar disclaims beneficial ownership of such securities except to the extent of its or his respective pecuniary interest therein. Mr. Schwab is a director of the Issuer and files separate Section 16 reports.

Footnote F5

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $0.33 to $0.36 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.