John Oyler - 10 Aug 2026 Form 4 Insider Report for BeOne Medicines Ltd. (ONC)

Reporting relationship
Chief Executive Officer, Director
Issuer ticker
ONC
Reported as of
10 Aug 2026
Net transaction value
-$86,480,472
Source evidence Original filing metadata and source links for verification. 4 source fields
SEC form
4
Accepted by SEC
12 Aug 2026, 17:53:28 UTC
Prior SEC filing
22 Jul 2026
Source filing
View source filing
Reporting owner 1 detail
Reporting owner signature
/s/ Frank Collazo, as Attorney-in-Fact

Key filing fact

John Oyler filed Form 4 for BeOne Medicines Ltd. (ONC) on 12 Aug 2026.

Key facts

  • This page summarizes John Oyler's Form 4 filing for BeOne Medicines Ltd. (ONC).
  • 24 reported transactions and 0 derivative rows are listed below.
  • Accepted by SEC: 12 Aug 2026, 17:53.

Change

  • Previous filing in this sequence was filed on 22 Jul 2026.
  • Current net transaction value: -$86,480,472.

Research use

  • This tells you what this filing adds before you inspect full transaction and derivative tables.
  • You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0001042047 Primary reporting owner

OYLER JOHN

Relationship
Chief Executive Officer, Director
Address
C/O BEONE MEDICINES I GMBH, AESCHENGRABEN 27, 21ST FLOOR, BASEL, SWITZERLAND
Signature
/s/ Frank Collazo, as Attorney-in-Fact
Signature date
12 Aug 2026

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

ONC transaction

American Depositary Shares

Sale

Transaction value
$23,450
Shares
-67
Change %
-0.03%
Price
$350.00
Shares after
240,743
Date
10 Aug 2026
Ownership
Direct
Footnotes
F6, F7
ONC transaction

American Depositary Shares

Sale

Transaction value
$989,603
Shares
-2,813
Change %
-1.2%
Price
$351.80
Shares after
237,930
Date
10 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F8
ONC transaction

American Depositary Shares

Sale

Transaction value
$1,297,741
Shares
-3,673
Change %
-1.5%
Price
$353.32
Shares after
234,257
Date
10 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F9
ONC transaction

American Depositary Shares

Sale

Transaction value
$2,383,028
Shares
-6,717
Change %
-2.9%
Price
$354.78
Shares after
227,540
Date
10 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F10
ONC transaction

American Depositary Shares

Sale

Transaction value
$1,236,261
Shares
-3,476
Change %
-1.5%
Price
$355.66
Shares after
224,064
Date
10 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F11
ONC transaction

American Depositary Shares

Sale

Transaction value
$4,428,482
Shares
-12,418
Change %
-5.5%
Price
$356.62
Shares after
211,646
Date
10 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F12
ONC transaction

American Depositary Shares

Sale

Transaction value
$5,675,864
Shares
-15,869
Change %
-7.5%
Price
$357.67
Shares after
195,777
Date
10 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F13
ONC transaction

American Depositary Shares

Sale

Transaction value
$16,157,076
Shares
-45,044
Change %
-23%
Price
$358.70
Shares after
150,733
Date
10 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F14
ONC transaction

American Depositary Shares

Sale

Transaction value
$7,640,826
Shares
-21,254
Change %
-14%
Price
$359.50
Shares after
129,479
Date
10 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F15
ONC transaction

American Depositary Shares

Sale

Transaction value
$1,327,130
Shares
-3,680
Change %
-2.8%
Price
$360.63
Shares after
125,799
Date
10 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F16
ONC transaction

American Depositary Shares

Sale

Transaction value
$4,920,844
Shares
-13,695
Change %
-11%
Price
$359.32
Shares after
112,104
Date
11 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F17
ONC transaction

American Depositary Shares

Sale

Transaction value
$2,911,849
Shares
-8,081
Change %
-7.2%
Price
$360.33
Shares after
104,023
Date
11 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F18
ONC transaction

American Depositary Shares

Sale

Transaction value
$5,266,268
Shares
-14,569
Change %
-14%
Price
$361.47
Shares after
89,454
Date
11 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F19
ONC transaction

American Depositary Shares

Sale

Transaction value
$4,191,548
Shares
-11,568
Change %
-13%
Price
$362.34
Shares after
77,886
Date
11 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F20
ONC transaction

American Depositary Shares

Sale

Transaction value
$4,871,344
Shares
-13,403
Change %
-17%
Price
$363.45
Shares after
64,483
Date
11 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F21
ONC transaction

American Depositary Shares

Sale

Transaction value
$1,898,442
Shares
-5,211
Change %
-8.1%
Price
$364.31
Shares after
59,272
Date
11 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F22
ONC transaction

American Depositary Shares

Sale

Transaction value
$1,160,079
Shares
-3,176
Change %
-5.4%
Price
$365.26
Shares after
56,096
Date
11 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F23
ONC transaction

American Depositary Shares

Sale

Transaction value
$439,574
Shares
-1,200
Change %
-2.1%
Price
$366.31
Shares after
54,896
Date
11 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F24
ONC transaction

American Depositary Shares

Sale

Transaction value
$1,468
Shares
-4
Change %
-0.01%
Price
$367.00
Shares after
54,892
Date
11 Aug 2026
Ownership
Direct
Footnotes
F6, F7
ONC transaction

American Depositary Shares

Sale

Transaction value
$702,320
Shares
-1,980
Change %
-3.6%
Price
$354.71
Shares after
52,912
Date
12 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F25
ONC transaction

American Depositary Shares

Sale

Transaction value
$896,426
Shares
-2,515
Change %
-4.8%
Price
$356.43
Shares after
50,397
Date
12 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F26
ONC transaction

American Depositary Shares

Sale

Transaction value
$5,506,147
Shares
-15,396
Change %
-31%
Price
$357.63
Shares after
35,001
Date
12 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F27
ONC transaction

American Depositary Shares

Sale

Transaction value
$7,490,448
Shares
-20,899
Change %
-60%
Price
$358.41
Shares after
14,102
Date
12 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F28
ONC transaction

American Depositary Shares

Sale

Transaction value
$5,064,252
Shares
-14,102
Change %
-100%
Price
$359.12
Shares after
0
Date
12 Aug 2026
Ownership
Direct
Footnotes
F6, F7, F29
ONC holding

Ordinary Shares

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
1,330,988
Date
10 Aug 2026
Ownership
Direct
ONC holding

Ordinary Shares

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
481,533
Date
10 Aug 2026
Ownership
See Footnote
Footnotes
F1
ONC holding

Ordinary Shares

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
7,699,158
Date
10 Aug 2026
Ownership
See Footnote
Footnotes
F2
ONC holding

Ordinary Shares

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
28,204,115
Date
10 Aug 2026
Ownership
See Footnote
Footnotes
F3
ONC holding

Ordinary Shares

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
9,545,000
Date
10 Aug 2026
Ownership
See Footnote
Footnotes
F4
ONC holding

Ordinary Shares

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
102,188
Date
10 Aug 2026
Ownership
See Footnote
Footnotes
F5
* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Rule 10b5-1 trading plan

These transactions were reported as open-market trades under a Rule 10b5-1 plan. The plan lets an insider set trading instructions in advance, which can reduce the risk of trading while in possession of material nonpublic information.

Original filing language: transaction made pursuant to a contract, instruction, or written plan intended to satisfy Rule 10b5-1(c).

Explanation of responses 29 footnotes

Footnote F1

These securities are held by the P&O Trust, the beneficiaries of which include the Reporting Person's child and others, for which the Reporting Person disclaims beneficial ownership.

Footnote F2

These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.

Footnote F3

These securities are held by Oyler Investment LLC, of which 99% of the limited liability company interests are owned by a grantor retain annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.

Footnote F4

These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account.

Footnote F5

These securities are held by The John Oyler Legacy Trust for the benefit of the Reporting Person's child, for which the Reporting Person disclaims beneficial ownership.

Footnote F6

Each American Depositary Share represents 13 Ordinary Shares.

Footnote F7

The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

Footnote F8

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $351.01 to $351.99, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F9

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $353.00 to $353.99, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F10

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $354.03 to $355.01, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F11

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $355.08 to $356.05, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F12

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $356.08 to $357.06, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F13

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $357.08 to $358.07, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F14

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $358.08 to $359.07, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F15

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $359.08 to $360.00, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F16

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $360.25 to $361.14, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F17

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $358.90 to $359.89, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F18

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $359.92 to $360.91, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F19

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $360.92 to $361.91, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F20

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $361.94 to $362.74, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F21

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $362.95 to $363.94, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F22

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $363.95 to $364.90, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F23

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $365.00 to $365.90, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F24

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $366.00 to $366.99, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F25

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $354.35 to $355.05, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F26

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $355.92 to $356.91, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F27

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $356.95 to $357.94, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F28

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $357.95 to $358.94, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F29

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $358.95 to $359.68, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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