John Oyler - 20 Jul 2026 Form 4 Insider Report for BeOne Medicines Ltd. (ONC)

Reporting relationship
Chief Executive Officer, Director
Issuer ticker
ONC
Reported as of
20 Jul 2026
Net transaction value
-$34,590,855
Source evidence Original filing metadata and source links for verification. 5 source fields
SEC form
4
Accepted by SEC
22 Jul 2026, 17:03:12 UTC
Prior SEC filing
17 Jul 2026
Next SEC filing
12 Aug 2026
Source filing
View source filing
Reporting owner 1 detail
Reporting owner signature
/s/ Frank Collazo, as Attorney-in-Fact

Key filing fact

John Oyler filed Form 4 for BeOne Medicines Ltd. (ONC) on 22 Jul 2026.

Key facts

  • This page summarizes John Oyler's Form 4 filing for BeOne Medicines Ltd. (ONC).
  • 16 reported transactions and 1 derivative row are listed below.
  • Accepted by SEC: 22 Jul 2026, 17:03.

Change

  • Previous filing in this sequence was filed on 17 Jul 2026.
  • Current net transaction value: -$34,590,855.

Research use

  • This tells you what this filing adds before you inspect full transaction and derivative tables.
  • You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0001042047 Primary reporting owner

OYLER JOHN

Relationship
Chief Executive Officer, Director
Address
C/O BEONE MEDICINES I GMBH, AESCHENGRABEN 27, 21ST FLOOR, BASEL, SWITZERLAND
Signature
/s/ Frank Collazo, as Attorney-in-Fact
Signature date
22 Jul 2026

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

ONC transaction

American Depositary Shares

Sale

Transaction value
$1,595,678
Shares
-5,146
Change %
-36%
Price
$310.08
Shares after
9,180
Date
20 Jul 2026
Ownership
Direct
Footnotes
F6, F7, F8
ONC transaction

American Depositary Shares

Sale

Transaction value
$1,949,310
Shares
-6,273
Change %
-68%
Price
$310.75
Shares after
2,907
Date
20 Jul 2026
Ownership
Direct
Footnotes
F6, F7, F9
ONC transaction

American Depositary Shares

Sale

Transaction value
$906,389
Shares
-2,907
Change %
-100%
Price
$311.80
Shares after
0
Date
20 Jul 2026
Ownership
Direct
Footnotes
F6, F7, F10
ONC transaction

American Depositary Shares

Options Exercise

Transaction value
Shares
+33,990
Change %
Price
$119.96*
Shares after
33,990
Date
20 Jul 2026
Ownership
Direct
Footnotes
F6
ONC transaction

American Depositary Shares

Sale

Transaction value
$4,840,115
Shares
-15,499
Change %
-46%
Price
$312.29
Shares after
18,491
Date
20 Jul 2026
Ownership
Direct
Footnotes
F6, F7, F11
ONC transaction

American Depositary Shares

Sale

Transaction value
$4,483,433
Shares
-14,326
Change %
-77%
Price
$312.96
Shares after
4,165
Date
20 Jul 2026
Ownership
Direct
Footnotes
F6, F7, F12
ONC transaction

American Depositary Shares

Sale

Transaction value
$580,732
Shares
-1,850
Change %
-44%
Price
$313.91
Shares after
2,315
Date
20 Jul 2026
Ownership
Direct
Footnotes
F6, F7, F13
ONC transaction

American Depositary Shares

Sale

Transaction value
$476,678
Shares
-1,512
Change %
-65%
Price
$315.26
Shares after
803
Date
20 Jul 2026
Ownership
Direct
Footnotes
F6, F7, F14
ONC transaction

American Depositary Shares

Sale

Transaction value
$165,339
Shares
-523
Change %
-65%
Price
$316.14
Shares after
280
Date
20 Jul 2026
Ownership
Direct
Footnotes
F6, F7, F15
ONC transaction

American Depositary Shares

Sale

Transaction value
$89,124
Shares
-280
Change %
-100%
Price
$318.30
Shares after
0
Date
20 Jul 2026
Ownership
Direct
Footnotes
F6, F7
ONC transaction

American Depositary Shares

Sale

Transaction value
$4,863,766
Shares
-15,379
Change %
-25%
Price
$316.26
Shares after
46,018
Date
21 Jul 2026
Ownership
Direct
Footnotes
F6, F7, F16
ONC transaction

American Depositary Shares

Sale

Transaction value
$6,347,340
Shares
-20,029
Change %
-44%
Price
$316.91
Shares after
25,989
Date
21 Jul 2026
Ownership
Direct
Footnotes
F6, F7, F17
ONC transaction

American Depositary Shares

Sale

Transaction value
$2,496,997
Shares
-7,842
Change %
-30%
Price
$318.41
Shares after
18,147
Date
21 Jul 2026
Ownership
Direct
Footnotes
F6, F7, F18
ONC transaction

American Depositary Shares

Sale

Transaction value
$5,047,019
Shares
-15,807
Change %
-87%
Price
$319.29
Shares after
2,340
Date
21 Jul 2026
Ownership
Direct
Footnotes
F6, F7, F19
ONC transaction

American Depositary Shares

Sale

Transaction value
$748,936
Shares
-2,340
Change %
-100%
Price
$320.06
Shares after
0
Date
21 Jul 2026
Ownership
Direct
Footnotes
F6, F7, F20
ONC holding

Ordinary Shares

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
4,461,518
Date
20 Jul 2026
Ownership
Direct
ONC holding

Ordinary Shares

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
481,533
Date
20 Jul 2026
Ownership
See Footnote
Footnotes
F1
ONC holding

Ordinary Shares

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
7,699,158
Date
20 Jul 2026
Ownership
See Footnote
Footnotes
F2
ONC holding

Ordinary Shares

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
28,204,115
Date
20 Jul 2026
Ownership
See Footnote
Footnotes
F3
ONC holding

Ordinary Shares

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
9,545,000
Date
20 Jul 2026
Ownership
See Footnote
Footnotes
F4
ONC holding

Ordinary Shares

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
102,188
Date
20 Jul 2026
Ownership
See Footnote
Footnotes
F5

Reported derivative securities

Options, warrants, convertible securities, or similar derivative positions disclosed in the filing.

ONC transaction Derivative

Share Option (Right to Buy)

Options Exercise

Transaction value
Shares
-441,870
Change %
-100%
Price
$0.000000*
Shares after
0
Date
20 Jul 2026
Ownership
Direct
Underlying class
Ordinary Shares
Underlying amount
441,870
Exercise price
$9.23
Footnotes
F21, F22
* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Rule 10b5-1 trading plan

These transactions were reported as open-market trades under a Rule 10b5-1 plan. The plan lets an insider set trading instructions in advance, which can reduce the risk of trading while in possession of material nonpublic information.

Original filing language: transaction made pursuant to a contract, instruction, or written plan intended to satisfy Rule 10b5-1(c).

Explanation of responses 22 footnotes

Footnote F1

These securities are held by the P&O Trust, the beneficiaries of which include the Reporting Person's child and others, for which the Reporting Person disclaims beneficial ownership.

Footnote F2

These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.

Footnote F3

These securities are held by Oyler Investment LLC, of which 99% of the limited liability company interests are owned by a grantor retain annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.

Footnote F4

These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account.

Footnote F5

These securities are held by The John Oyler Legacy Trust for the benefit of the Reporting Person's child, for which the Reporting Person disclaims beneficial ownership.

Footnote F6

Each American Depositary Share represents 13 Ordinary Shares.

Footnote F7

The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

Footnote F8

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $309.39 to $310.38, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F9

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $310.39 to $311.36, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F10

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $311.46 to $311.98, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F11

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $311.98 to $312.45, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F12

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $312.46 to $313.39, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F13

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $313.47 to $314.36, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F14

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $314.74 to $315.60, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F15

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $315.91 to $316.33, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F16

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $315.67 to $316.66, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F17

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $316.67 to $317.62, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F18

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $317.72 to $318.685, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F19

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $318.79 to $319.78, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F20

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $319.82 to $320.39, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Footnote F21

The number of securities underlying each option and the exercise price therefore are represented in ordinary shares.

Footnote F22

These securities vest over a four-year period as follows: 25% on June 5, 2020, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.

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