Samira Shaikhly - 29 Jun 2026 Form 4 Insider Report for Septerna, Inc. (SEPN)

Reporting relationship: Chief People Officer
Issuer ticker: SEPN
Reported as of: 29 Jun 2026
Net transaction value: -$76,622
SEC form: 4
Accepted by SEC: 30 Jun 2026, 19:01:37 UTC
Prior SEC filing: 16 Jun 2026
Source filing: View source filing
Reporting owner signature: /s/ Mark A. Wilson, Attorney-in-Fact

Key filing fact

Samira Shaikhly filed Form 4 for Septerna, Inc. (SEPN) on 30 Jun 2026.

Key facts

This page summarizes Samira Shaikhly's Form 4 filing for Septerna, Inc. (SEPN).
3 reported transactions and 1 derivative row are listed below.
Accepted by SEC: 30 Jun 2026, 19:01.

Change

Previous filing in this sequence was filed on 16 Jun 2026.
Current net transaction value: -$76,622.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0002040363 Primary reporting owner

Shaikhly Samira

Relationship: Chief People Officer
Address: C/O SEPTERNA, INC., 250 EAST GRAND AVENUE, SOUTH SAN FRANCISCO
Signature: /s/ Mark A. Wilson, Attorney-in-Fact
Signature date: 30 Jun 2026

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

SEPN transaction

Common Stock

Options Exercise

Transaction value
Shares: +2,178
Change %: +275%
Price: $6.81^*
Shares after: 2,971
Date: 29 Jun 2026
Ownership: Direct

SEPN transaction

Common Stock

Sale

Transaction value: $76,622
Shares: -2,178
Change %: -73%
Price: $35.18
Shares after: 793
Date: 29 Jun 2026
Ownership: Direct
Footnotes: F1

Reported derivative securities

Options, warrants, convertible securities, or similar derivative positions disclosed in the filing.

SEPN transaction Derivative

Stock Option (Right to Buy)

Options Exercise

Transaction value
Shares: -2,178
Change %: -9.5%
Price: $0.000000^*
Shares after: 20,865
Date: 29 Jun 2026
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 2,178
Exercise price: $6.81
Footnotes: F2

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Rule 10b5-1 trading plan

These transactions were reported as open-market trades under a Rule 10b5-1 plan. The plan lets an insider set trading instructions in advance, which can reduce the risk of trading while in possession of material nonpublic information.

Original filing language: transaction made pursuant to a contract, instruction, or written plan intended to satisfy Rule 10b5-1(c).

Explanation of responses 2 footnotes

Footnote F1

This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.

Footnote F2

1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of October 28, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.