Jake Simson - 26 Jun 2026 Form 4 Insider Report for Septerna, Inc. (SEPN)

Reporting relationship: Director
Issuer ticker: SEPN
Reported as of: 26 Jun 2026
Net transaction value: $0
SEC form: 4
Accepted by SEC: 30 Jun 2026, 19:00:04 UTC
Prior SEC filing: 12 Jun 2026
Source filing: View source filing
Reporting owner signature: /s/ Mark A. Wilson, Attorney-in-Fact

Key filing fact

Jake Simson filed Form 4 for Septerna, Inc. (SEPN) on 30 Jun 2026.

Key facts

This page summarizes Jake Simson's Form 4 filing for Septerna, Inc. (SEPN).
1 reported transaction and 1 derivative row are listed below.
Accepted by SEC: 30 Jun 2026, 19:00.

Change

Previous filing in this sequence was filed on 12 Jun 2026.
Current net transaction value: $0.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0001863094 Primary reporting owner

Simson Jake

Relationship: Director
Address: C/O SEPTERNA, INC., 250 EAST GRAND AVENUE, SOUTH SAN FRANCISCO
Signature: /s/ Mark A. Wilson, Attorney-in-Fact
Signature date: 30 Jun 2026

Reported derivative securities

Options, warrants, convertible securities, or similar derivative positions disclosed in the filing.

SEPN transaction Derivative

Stock Option (Right to Buy)

Award

Transaction value
Shares: +15,000
Change %
Price: $0.000000^*
Shares after: 15,000
Date: 26 Jun 2026
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 15,000
Exercise price: $37.34
Footnotes: F1, F2

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Explanation of responses 2 footnotes

Footnote F1

The shares underlying the stock option vest in full upon the earlier of (i) June 26, 2027 or (ii) the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer through such vesting date.

Footnote F2

Under the Reporting Person's arrangement with RA Capital Management, L.P. (the "Adviser"), the Reporting Person holds the option for the benefit of the R.A. Capital Healthcare Fund, L.P. (the "Fund") and R.A. Capital Nexus Fund III, L.P. (the "Nexus Fund III"). The Reporting Person is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund and the Nexus Fund III to the Adviser. The Reporting Person therefore disclaims beneficial ownership of the option and underlying common stock.

SEC remarks

Exhibit 24.2 - Substitute Power of Attorney