Veronica Sanchez Bulis - 31 Oct 2025 Form 3 Insider Report for Lyell Immunopharma, Inc. (LYEL)

Role: VP, Corporate Controller
Signature: /s/ Mark Meltz, Attorney-in-Fact
Issuer symbol: LYEL
Transactions as of: 31 Oct 2025
Net transactions value: $0
Form type: 3
Filing time: 10 Nov 2025, 21:07:59 UTC
Next filing: 12 Nov 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Bulis Veronica Sanchez	VP, Corporate Controller	C/O LYELL IMMUNOPHARMA, INC., 201 HASKINS WAY, SUITE 101, SOUTH SAN FRANCISCO	/s/ Mark Meltz, Attorney-in-Fact	10 Nov 2025	0002095702

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
holding	LYEL	Common Stock						9,452	31 Oct 2025	Direct	F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
holding	LYEL	Option (right to buy)							31 Oct 2025	Common Stock	1,674	$42.60	Direct	F2
holding	LYEL	Option (right to buy)							31 Oct 2025	Common Stock	624	$37.40	Direct	F3
holding	LYEL	Option (right to buy)							31 Oct 2025	Common Stock	3,000	$37.40	Direct	F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Includes restricted stock units ("RSUs") under the Issuer's 2021 Equity Incentive Plan that are subject to time-based vesting and will be settled in common stock subject to vesting as follows: (1) 38 shares that will vest quarterly over the six-month period following August 9, 2025; (2) 312 shares that will vest quarterly over the eighteen-month period following August 9, 2025; (3) 2,516 shares that vest quarterly over the thirty month period following August 9, 2025 and (4) 3,937 shares that vest quarterly over the forty-two-month period following August 9, 2025; in each case, subject to the reporting person providing service through the applicable vesting date.
F2	12.5% of the option shares vested on August 9, 2023, with the remaining option shares to vest in equal monthly installments over the following forty-two months, subject to the reporting person providing service through the applicable vesting date.
F3	12.5% of the option shares vested on August 9, 2022, with the remaining option shares to vest in equal monthly installments over the following forty-two months, subject to the reporting person providing service through the applicable vesting date.
F4	Fully vested.