| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Walbert Keli | Director | C/O SPRUCE BIOSCIENCES, INC., 611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO | /s/ Samir Gharib, Attorney-in-Fact | 15 Dec 2025 | 0002051489 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | SPRB | Stock Option (Right to Buy) | Award | $0 | +3,400 | $0.000000 | 3,400 | 11 Dec 2025 | Common Stock | 3,400 | $88.41 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | The option vests in equal monthly installments over a three year period such that the option is fully vested on the third anniversary of the date of grant, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan") through each such vesting date and will vest in full upon a Change in Control (as defined in the Plan). |