| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Ede-Golightly James | Director | C/O SILENCE THERAPEUTICS PLC, 12 HAMMERSMITH GROVE, LONDON, UNITED KINGDOM | /s/ Rhonda Hellums, Attorney-in-Fact | 22 Dec 2025 | 0002048873 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| holding | SLN | Ordinary Shares | 15,000 | 14 Dec 2025 | Direct |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| holding | SLN | Share Option (Right to Buy) | 14 Dec 2025 | Ordinary Shares | 48,000 | $7.87 | Direct | F1 | ||||||
| holding | SLN | Share Option (Right to Buy) | 14 Dec 2025 | Ordinary Shares | 27,999 | $5.13 | Direct | F1 | ||||||
| holding | SLN | Share Option (Right to Buy) | 14 Dec 2025 | Ordinary Shares | 22,668 | $5.90 | Direct | F1 | ||||||
| holding | SLN | Share Option (Right to Buy) | 14 Dec 2025 | Ordinary Shares | 6,666 | $2.40 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | Immediately exercisable. |