Javier B. Szwarcberg - 31 Dec 2025 Form 4 Insider Report for SPRUCE BIOSCIENCES, INC. (SPRB)

Role: CHIEF EXECUTIVE OFFICER, Director
Signature: /s/ Samir Gharib, Attorney-in-Fact
Issuer symbol: SPRB
Transactions as of: 31 Dec 2025
Net transactions value: +$21,248
Form type: 4
Filing time: 05 Jan 2026, 16:43:53 UTC
Previous filing: 15 Dec 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Szwarcberg Javier B.	CHIEF EXECUTIVE OFFICER, Director	C/O SPRUCE BIOSCIENCES, INC., 611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO	/s/ Samir Gharib, Attorney-in-Fact	05 Jan 2026	0001903669

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	SPRB	Common Stock	Award	$21,248	+4,690	+33%	$4.53	19,004	31 Dec 2025	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Shares acquired by the Reporting Person pursuant to the Issuer's 2020 Employee Stock Purchase Plan in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c). The Reporting Person acquired the maximum shares allowable pursuant to Section 423 of the Internal Revenue Code.