Mark Worthington - 03 Mar 2026 Form 4 Insider Report for LeonaBio, Inc. (LONA)

Role: GENERAL COUNSEL and CCO
Signature: /s/ Mark Worthington
Issuer symbol: LONA
Transactions as of: 03 Mar 2026
Net transactions value: -$7,131
Form type: 4
Filing time: 05 Mar 2026, 19:06:26 UTC
Previous filing: 05 Jan 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Worthington Mark	GENERAL COUNSEL and CCO	C/O LEONABIO, INC., 18706 NORTH CREEK PARKWAY, SUITE 104, BOTHELL	/s/ Mark Worthington	05 Mar 2026	0001861464

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	LONA	Common Stock	Options Exercise		+5,726	+41%	$0.000000^*	19,704	03 Mar 2026	Direct
transaction	LONA	Common Stock	Sale	$7,131	-1,328	-6.7%	$5.37	18,376	04 Mar 2026	Direct	F1, F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	LONA	Restricted Stock Units	Options Exercise		-5,726	-100%	$0.000000^*	0	03 Mar 2026	Common Stock	5,726		Direct	F3, F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents shares of common stock sold to cover tax withholding and remittance obligations in connection with the vesting of restricted stock units ("RSU") pursuant to mandatory "sell to cover" policies maintained by the Issuer and provisions contained in the reporting person's applicable RSU agreement, and does not represent a discretionary sale by the reporting person. No additional shares of common stock were sold by the reporting person.
F2	The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $5.03 to $5.70, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.
F3	Each RSU represents a contingent right to receive one (1) share of Issuer's common stock.
F4	On March 3, 2025, the reporting person was granted 5,726 RSUs (as adjusted for the 10-for-1 reverse stock split completed on September 17, 2025). 100% of the RSUs vested on the one (1) year anniversary of the grant date.