Mario Alberto Accardi - 01 Aug 2025 Form 4 Insider Report for Centessa Pharmaceuticals plc (CNTA)

Role: President, Orexin Program
Signature: /s/ Richard Menziuso, attorney-in-fact
Issuer symbol: CNTA
Transactions as of: 01 Aug 2025
Net transactions value: -$10,250
Form type: 4
Filing time: 01 Aug 2025, 17:00:11 UTC
Previous filing: 30 Jul 2025
Next filing: 11 Sep 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Accardi Mario Alberto	President, Orexin Program	C/O CENTESSA PHARMACEUTICALS PLC, 3RD FL., 1 ASHLEY RD, ALTRINCHAM, CHESHIRE, UNITED KINGDOM	/s/ Richard Menziuso, attorney-in-fact	01 Aug 2025	0002074392

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	CNTA	Ordinary Shares	Tax liability	$10,250	-597	-0.29%	$17.17	207,566	01 Aug 2025	Direct	F1, F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.
F2	Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of restricted share units.